Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer.
BACKGROUND: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also allow them to evade from effector T-cell resp...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3559740?pdf=render |
| _version_ | 1818143571898793984 |
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| author | Mia Kim Tanja Grimmig Martin Grimm Maria Lazariotou Eva Meier Andreas Rosenwald Igor Tsaur Roman Blaheta Uwe Heemann Christoph-Thomas Germer Ana Maria Waaga-Gasser Martin Gasser |
| author_facet | Mia Kim Tanja Grimmig Martin Grimm Maria Lazariotou Eva Meier Andreas Rosenwald Igor Tsaur Roman Blaheta Uwe Heemann Christoph-Thomas Germer Ana Maria Waaga-Gasser Martin Gasser |
| author_sort | Mia Kim |
| collection | DOAJ |
| description | BACKGROUND: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also allow them to evade from effector T-cell responses, resulting in a survival benefit of the tumor. For colorectal cancer (CRC) the clinical relevance of Foxp3 has not been evaluated in detail. Therefore the aim of this study was to study its impact in colorectal cancer (CRC). METHODS AND FINDINGS: Gene and protein analysis of tumor tissues from patients with CRC was performed to quantify the expression of Foxp3 in tumor infiltrating Treg and colon cancer cells. The results were correlated with clinicopathological parameters and patients overall survival. Serial morphological analysis demonstrated Foxp3 to be expressed in cancer cells. High Foxp3 expression of the cancer cells was associated with poor prognosis compared to patients with low Foxp3 expression. In contrast, low and high Foxp3 level in tumor infiltrating Treg cells demonstrated no significant differences in overall patient survival. CONCLUSIONS: Our findings strongly suggest that Foxp3 expression mediated by cancer cells rather than by Treg cells contribute to disease progression. |
| first_indexed | 2024-12-11T11:33:48Z |
| format | Article |
| id | doaj.art-3059ab95b71d4ed5b07375d1c6d92ce2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T11:33:48Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3059ab95b71d4ed5b07375d1c6d92ce22022-12-22T01:08:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5363010.1371/journal.pone.0053630Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer.Mia KimTanja GrimmigMartin GrimmMaria LazariotouEva MeierAndreas RosenwaldIgor TsaurRoman BlahetaUwe HeemannChristoph-Thomas GermerAna Maria Waaga-GasserMartin GasserBACKGROUND: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also allow them to evade from effector T-cell responses, resulting in a survival benefit of the tumor. For colorectal cancer (CRC) the clinical relevance of Foxp3 has not been evaluated in detail. Therefore the aim of this study was to study its impact in colorectal cancer (CRC). METHODS AND FINDINGS: Gene and protein analysis of tumor tissues from patients with CRC was performed to quantify the expression of Foxp3 in tumor infiltrating Treg and colon cancer cells. The results were correlated with clinicopathological parameters and patients overall survival. Serial morphological analysis demonstrated Foxp3 to be expressed in cancer cells. High Foxp3 expression of the cancer cells was associated with poor prognosis compared to patients with low Foxp3 expression. In contrast, low and high Foxp3 level in tumor infiltrating Treg cells demonstrated no significant differences in overall patient survival. CONCLUSIONS: Our findings strongly suggest that Foxp3 expression mediated by cancer cells rather than by Treg cells contribute to disease progression.http://europepmc.org/articles/PMC3559740?pdf=render |
| spellingShingle | Mia Kim Tanja Grimmig Martin Grimm Maria Lazariotou Eva Meier Andreas Rosenwald Igor Tsaur Roman Blaheta Uwe Heemann Christoph-Thomas Germer Ana Maria Waaga-Gasser Martin Gasser Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer. PLoS ONE |
| title | Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer. |
| title_full | Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer. |
| title_fullStr | Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer. |
| title_full_unstemmed | Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer. |
| title_short | Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer. |
| title_sort | expression of foxp3 in colorectal cancer but not in treg cells correlates with disease progression in patients with colorectal cancer |
| url | http://europepmc.org/articles/PMC3559740?pdf=render |
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