Genetic polymorphism of 38 Y-chromosome short tandem repeats in Beijing han population from China
Objective: To investigate 38 Y-chromosome short tandem repeat (Y-STR) genetic polymorphisms in Beijing Han and analyze the genetic distance with neighboring or linguistically similar populations. Materials and Methods: In the study, we selected 531 unrelated male individuals of Beijing Han, and the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Forensic Science and Medicine |
| Subjects: | |
| Online Access: | http://www.jfsmonline.com/article.asp?issn=2349-5014;year=2023;volume=9;issue=4;spage=340;epage=346;aulast=Liu |
| _version_ | 1797232648908701696 |
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| author | Yan Liu Chengtao Jiang Dong Zhao Jinpei Zhang Libin Wu Di Lu Li Yuan |
| author_facet | Yan Liu Chengtao Jiang Dong Zhao Jinpei Zhang Libin Wu Di Lu Li Yuan |
| author_sort | Yan Liu |
| collection | DOAJ |
| description | Objective: To investigate 38 Y-chromosome short tandem repeat (Y-STR) genetic polymorphisms in Beijing Han and analyze the genetic distance with neighboring or linguistically similar populations. Materials and Methods: In the study, we selected 531 unrelated male individuals of Beijing Han, and the results were statistically analyzed by testing with GSTAR™ 41Y reagents. Results: The allele peak heights were balanced among the Y loci, the amplified fragment ranged from 100 to 500 bps. A total of 531 haplotypes were detected in 531 samples. Eight null genotypes were observed on locus DYS448. One and three double alleles were observed on single-copy locus DYS576 and DYS19, respectively. DYS385 a/b, DYF387S1 a/b, and DYS527 a/b were more common in double copies, but 3, 13, and 11 triple alleles were detected, respectively. The gene diversity values of Y-STRs except DYS391, DYS438, and DYS645 were >0.5. Twenty-seven Y-STRs of Beijing Han population were selected for genetic distance comparison with 17 populations including Changchun Han, with Rst values ranging from 0.0002 to 0.1703. Conclusion: The 38 Y-STRs in this study have strong male lineage identification ability and have great potential for individual identification, kinship identification, Y-STR database construction, and genetic relationship research. |
| first_indexed | 2024-04-24T16:03:37Z |
| format | Article |
| id | doaj.art-305bbbc0231f491ab66a89b21a870474 |
| institution | Directory Open Access Journal |
| issn | 2349-5014 |
| language | English |
| last_indexed | 2024-04-24T16:03:37Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Forensic Science and Medicine |
| spelling | doaj.art-305bbbc0231f491ab66a89b21a8704742024-04-01T06:00:39ZengWolters Kluwer Medknow PublicationsJournal of Forensic Science and Medicine2349-50142023-01-019434034610.4103/jfsm.jfsm_105_23Genetic polymorphism of 38 Y-chromosome short tandem repeats in Beijing han population from ChinaYan LiuChengtao JiangDong ZhaoJinpei ZhangLibin WuDi LuLi YuanObjective: To investigate 38 Y-chromosome short tandem repeat (Y-STR) genetic polymorphisms in Beijing Han and analyze the genetic distance with neighboring or linguistically similar populations. Materials and Methods: In the study, we selected 531 unrelated male individuals of Beijing Han, and the results were statistically analyzed by testing with GSTAR™ 41Y reagents. Results: The allele peak heights were balanced among the Y loci, the amplified fragment ranged from 100 to 500 bps. A total of 531 haplotypes were detected in 531 samples. Eight null genotypes were observed on locus DYS448. One and three double alleles were observed on single-copy locus DYS576 and DYS19, respectively. DYS385 a/b, DYF387S1 a/b, and DYS527 a/b were more common in double copies, but 3, 13, and 11 triple alleles were detected, respectively. The gene diversity values of Y-STRs except DYS391, DYS438, and DYS645 were >0.5. Twenty-seven Y-STRs of Beijing Han population were selected for genetic distance comparison with 17 populations including Changchun Han, with Rst values ranging from 0.0002 to 0.1703. Conclusion: The 38 Y-STRs in this study have strong male lineage identification ability and have great potential for individual identification, kinship identification, Y-STR database construction, and genetic relationship research.http://www.jfsmonline.com/article.asp?issn=2349-5014;year=2023;volume=9;issue=4;spage=340;epage=346;aulast=Liugenetic distancegenetic polymorphismhan nationality in beijingshort tandem repeatsy-chromosome |
| spellingShingle | Yan Liu Chengtao Jiang Dong Zhao Jinpei Zhang Libin Wu Di Lu Li Yuan Genetic polymorphism of 38 Y-chromosome short tandem repeats in Beijing han population from China Journal of Forensic Science and Medicine genetic distance genetic polymorphism han nationality in beijing short tandem repeats y-chromosome |
| title | Genetic polymorphism of 38 Y-chromosome short tandem repeats in Beijing han population from China |
| title_full | Genetic polymorphism of 38 Y-chromosome short tandem repeats in Beijing han population from China |
| title_fullStr | Genetic polymorphism of 38 Y-chromosome short tandem repeats in Beijing han population from China |
| title_full_unstemmed | Genetic polymorphism of 38 Y-chromosome short tandem repeats in Beijing han population from China |
| title_short | Genetic polymorphism of 38 Y-chromosome short tandem repeats in Beijing han population from China |
| title_sort | genetic polymorphism of 38 y chromosome short tandem repeats in beijing han population from china |
| topic | genetic distance genetic polymorphism han nationality in beijing short tandem repeats y-chromosome |
| url | http://www.jfsmonline.com/article.asp?issn=2349-5014;year=2023;volume=9;issue=4;spage=340;epage=346;aulast=Liu |
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