TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells
LPS is a major component of gram-negative bacterial cell walls, and triggers immune responses in airway epithelium by activating TLR4. Here the authors show that LPS also activates TRPV4, thereby inducing fast defense responses such as nitric oxide production and increased ciliary beating in mice.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01201-3 |
| _version_ | 1818682389678784512 |
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| author | Yeranddy A. Alpizar Brett Boonen Alicia Sanchez Carole Jung Alejandro López-Requena Robbe Naert Brecht Steelant Katrien Luyts Cristina Plata Vanessa De Vooght Jeroen A. J. Vanoirbeek Victor M. Meseguer Thomas Voets Julio L. Alvarez Peter W. Hellings Peter H. M. Hoet Benoit Nemery Miguel A. Valverde Karel Talavera |
| author_facet | Yeranddy A. Alpizar Brett Boonen Alicia Sanchez Carole Jung Alejandro López-Requena Robbe Naert Brecht Steelant Katrien Luyts Cristina Plata Vanessa De Vooght Jeroen A. J. Vanoirbeek Victor M. Meseguer Thomas Voets Julio L. Alvarez Peter W. Hellings Peter H. M. Hoet Benoit Nemery Miguel A. Valverde Karel Talavera |
| author_sort | Yeranddy A. Alpizar |
| collection | DOAJ |
| description | LPS is a major component of gram-negative bacterial cell walls, and triggers immune responses in airway epithelium by activating TLR4. Here the authors show that LPS also activates TRPV4, thereby inducing fast defense responses such as nitric oxide production and increased ciliary beating in mice. |
| first_indexed | 2024-12-17T10:18:04Z |
| format | Article |
| id | doaj.art-305c11c87f63412e9d5471df82642beb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:18:04Z |
| publishDate | 2017-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-305c11c87f63412e9d5471df82642beb2022-12-21T21:52:51ZengNature PortfolioNature Communications2041-17232017-10-018111310.1038/s41467-017-01201-3TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cellsYeranddy A. Alpizar0Brett Boonen1Alicia Sanchez2Carole Jung3Alejandro López-Requena4Robbe Naert5Brecht Steelant6Katrien Luyts7Cristina Plata8Vanessa De Vooght9Jeroen A. J. Vanoirbeek10Victor M. Meseguer11Thomas Voets12Julio L. Alvarez13Peter W. Hellings14Peter H. M. Hoet15Benoit Nemery16Miguel A. Valverde17Karel Talavera18Department of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU LeuvenDepartment of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU LeuvenDepartment of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU LeuvenDepartment of Experimental and Health Sciences, Laboratory of Molecular Physiology and Channelopathies, Universitat Pompeu FabraDepartment of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU LeuvenDepartment of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU LeuvenDepartment of Microbiology and Immunology, Laboratory of Clinical Immunology, KU LeuvenDepartment of Public Health and Care, Laboratory of Environment and Health, KU LeuvenDepartment of Experimental and Health Sciences, Laboratory of Molecular Physiology and Channelopathies, Universitat Pompeu FabraDepartment of Public Health and Care, Laboratory of Environment and Health, KU LeuvenDepartment of Public Health and Care, Laboratory of Environment and Health, KU LeuvenInstituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSICDepartment of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU LeuvenDepartment of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU LeuvenDepartment of Microbiology and Immunology, Laboratory of Clinical Immunology, KU LeuvenDepartment of Public Health and Care, Laboratory of Environment and Health, KU LeuvenDepartment of Public Health and Care, Laboratory of Environment and Health, KU LeuvenDepartment of Experimental and Health Sciences, Laboratory of Molecular Physiology and Channelopathies, Universitat Pompeu FabraDepartment of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU LeuvenLPS is a major component of gram-negative bacterial cell walls, and triggers immune responses in airway epithelium by activating TLR4. Here the authors show that LPS also activates TRPV4, thereby inducing fast defense responses such as nitric oxide production and increased ciliary beating in mice.https://doi.org/10.1038/s41467-017-01201-3 |
| spellingShingle | Yeranddy A. Alpizar Brett Boonen Alicia Sanchez Carole Jung Alejandro López-Requena Robbe Naert Brecht Steelant Katrien Luyts Cristina Plata Vanessa De Vooght Jeroen A. J. Vanoirbeek Victor M. Meseguer Thomas Voets Julio L. Alvarez Peter W. Hellings Peter H. M. Hoet Benoit Nemery Miguel A. Valverde Karel Talavera TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells Nature Communications |
| title | TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells |
| title_full | TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells |
| title_fullStr | TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells |
| title_full_unstemmed | TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells |
| title_short | TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells |
| title_sort | trpv4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells |
| url | https://doi.org/10.1038/s41467-017-01201-3 |
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