Desulfovibrio bacteria enhance alpha-synuclein aggregation in a Caenorhabditis elegans model of Parkinson’s disease

Desulfovibrio bacteria enhance alpha-synuclein aggregation in a Caenorhabditis elegans model of Parkinson’s disease

IntroductionThe aggregation of the neuronal protein alpha-synuclein (alpha-syn) is a key feature in the pathology of Parkinson’s disease (PD). Alpha-syn aggregation has been suggested to be induced in the gut cells by pathogenic gut microbes such as Desulfovibrio bacteria, which has been shown to be...

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Bibliographic Details
Main Authors: Vy A. Huynh, Timo M. Takala, Kari E. Murros, Bidhi Diwedi, Per E. J. Saris
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Parkinson’s disease
gut Desulfovibrio bacteria
alpha-synuclein (alpha-syn)
C. elegans
hydrogen sulfide
lipopolysaccharides
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1181315/full

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