Association between <i>Interleukin-1</i> Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis
Background and objective: Interleukins (ILs), as important biochemical mediators, control the host response to inflammation and are associated with bone resorption. In the present meta-analysis, we investigated the association between <i>IL−1</i> polymorphisms and susceptibility to denta...
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MDPI AG
2021-12-01
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| Online Access: | https://www.mdpi.com/2076-0817/10/12/1600 |
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| author | Hady Mohammadi Mehrnoush Momeni Roochi Masoud Sadeghi Ata Garajei Hosein Heidar Ali Aghaie Meybodi Mohsen Dallband Sarton Mostafavi Melina Mostafavi Mojtaba Salehi Jyothi Tadakamadla Dena Sadeghi-Bahmani Serge Brand |
| author_facet | Hady Mohammadi Mehrnoush Momeni Roochi Masoud Sadeghi Ata Garajei Hosein Heidar Ali Aghaie Meybodi Mohsen Dallband Sarton Mostafavi Melina Mostafavi Mojtaba Salehi Jyothi Tadakamadla Dena Sadeghi-Bahmani Serge Brand |
| author_sort | Hady Mohammadi |
| collection | DOAJ |
| description | Background and objective: Interleukins (ILs), as important biochemical mediators, control the host response to inflammation and are associated with bone resorption. In the present meta-analysis, we investigated the association between <i>IL−1</i> polymorphisms and susceptibility to dental peri-implant disease (PID). Materials and methods: We searched Web of Science, Cochrane Library, Scopus, and PubMed/Medline databases for studies published until 9 September2021, without any restrictions. We calculated the crude OR and 95% confidence intervals (CI) to estimate the associations between <i>IL−1</i> polymorphisms and PID risk in the five genetic models. We further performed the subgroup analysis, sensitivity analysis, meta-regression, trial sequential analysis, and calculated the publication bias. Results: Out of 212 retrieved records, sixteen articles were used in the meta-analysis. There was no association between <i>IL−1A (–889), IL−1B (−511), IL−1B (+3953),</i> and <i>IL−1RN (VNTR)</i> polymorphisms and the risk of dental PIDs, but there was an increased risk of <i>IL−1B (+3954)</i> in the patients with PIDs. In addition, an association of the composite genotype of <i>IL−1A (−889)/IL−1B (+3953)</i> was observed with the risk of PIDs, but not for the composite genotype of <i>IL−1A (−889)/IL−1B (+3954)</i>. The publication year, the ethnicity, sample size, and the outcome were significantly influenced pooled estimates of some genetic models. Trial sequential analysis showed the lack of sufficient sample sizes in the studies. <b>Conclusions</b>: Among IL−1 polymorphisms evaluated in the meta-analysis, the composite genotype of <i>IL−1A (−889)/IL−1B (+3953)</i> and <i>IL−1B (+3954)</i> were the only polymorphisms associated with the risk of PID. The T allele and CT genotype of <i>IL−1B (+3954)</i> polymorphism were also associated with an elevated risk of PID. |
| first_indexed | 2024-03-10T03:21:13Z |
| format | Article |
| id | doaj.art-305d3ff7c1fb4de88565e21dadbe13ff |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T03:21:13Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
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| series | Pathogens |
| spelling | doaj.art-305d3ff7c1fb4de88565e21dadbe13ff2023-11-23T10:01:17ZengMDPI AGPathogens2076-08172021-12-011012160010.3390/pathogens10121600Association between <i>Interleukin-1</i> Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-AnalysisHady Mohammadi0Mehrnoush Momeni Roochi1Masoud Sadeghi2Ata Garajei3Hosein Heidar4Ali Aghaie Meybodi5Mohsen Dallband6Sarton Mostafavi7Melina Mostafavi8Mojtaba Salehi9Jyothi Tadakamadla10Dena Sadeghi-Bahmani11Serge Brand12Department of Oral and Maxillofacial Surgery, Fellowship in Maxillofacial Trauma, Health Services, Kurdistan University of Medical Sciences, Sanandaj 6617713446, IranDepartment of Oral and Maxillofacial Surgery, Fellowship in Maxillofacial Trauma, School of Dentistry, Tehran University of Medical Sciences, Tehran 1439955991, IranDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran 1477893855, IranDepartment of Head and Neck Surgical Oncology and Reconstructive Surgery, The Cancer Institute, School of Medicine, Tehran University of Medical Sciences, Tehran 1439955991, IranDepartment of Oral and Maxillofacial Surgery, Fellowship in Maxillofacial Trauma, School of Dentistry, Tehran University of Medical Sciences, Tehran 1439955991, IranDepartment of Head and Neck Surgical Oncology and Reconstructive Surgery, The Cancer Institute, School of Medicine, Tehran University of Medical Sciences, Tehran 1439955991, IranDepartment of Oral and Maxillofacial Surgery, Dental School, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, IranEnglish Department, Baneh Branch, Islamic Azad University, Baneh 6691133845, IranTehran Medical Branch, Islamic Azad University, Tehran 1419733171, IranDepartment of Oral and Maxillofacial Surgery, Fellowship in Maxillofacial Trauma, School of Dentistry, Tehran University of Medical Sciences, Tehran 1439955991, IranSchool of Medicine and Dentistry, Griffith University, Brisbane, QLD 4222, AustraliaSleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah 6719851115, IranSleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah 6719851115, IranBackground and objective: Interleukins (ILs), as important biochemical mediators, control the host response to inflammation and are associated with bone resorption. In the present meta-analysis, we investigated the association between <i>IL−1</i> polymorphisms and susceptibility to dental peri-implant disease (PID). Materials and methods: We searched Web of Science, Cochrane Library, Scopus, and PubMed/Medline databases for studies published until 9 September2021, without any restrictions. We calculated the crude OR and 95% confidence intervals (CI) to estimate the associations between <i>IL−1</i> polymorphisms and PID risk in the five genetic models. We further performed the subgroup analysis, sensitivity analysis, meta-regression, trial sequential analysis, and calculated the publication bias. Results: Out of 212 retrieved records, sixteen articles were used in the meta-analysis. There was no association between <i>IL−1A (–889), IL−1B (−511), IL−1B (+3953),</i> and <i>IL−1RN (VNTR)</i> polymorphisms and the risk of dental PIDs, but there was an increased risk of <i>IL−1B (+3954)</i> in the patients with PIDs. In addition, an association of the composite genotype of <i>IL−1A (−889)/IL−1B (+3953)</i> was observed with the risk of PIDs, but not for the composite genotype of <i>IL−1A (−889)/IL−1B (+3954)</i>. The publication year, the ethnicity, sample size, and the outcome were significantly influenced pooled estimates of some genetic models. Trial sequential analysis showed the lack of sufficient sample sizes in the studies. <b>Conclusions</b>: Among IL−1 polymorphisms evaluated in the meta-analysis, the composite genotype of <i>IL−1A (−889)/IL−1B (+3953)</i> and <i>IL−1B (+3954)</i> were the only polymorphisms associated with the risk of PID. The T allele and CT genotype of <i>IL−1B (+3954)</i> polymorphism were also associated with an elevated risk of PID.https://www.mdpi.com/2076-0817/10/12/1600peri-implant diseaseperi-implantitisbone losspolymorphism<i>interleukin−1</i> |
| spellingShingle | Hady Mohammadi Mehrnoush Momeni Roochi Masoud Sadeghi Ata Garajei Hosein Heidar Ali Aghaie Meybodi Mohsen Dallband Sarton Mostafavi Melina Mostafavi Mojtaba Salehi Jyothi Tadakamadla Dena Sadeghi-Bahmani Serge Brand Association between <i>Interleukin-1</i> Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis Pathogens peri-implant disease peri-implantitis bone loss polymorphism <i>interleukin−1</i> |
| title | Association between <i>Interleukin-1</i> Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis |
| title_full | Association between <i>Interleukin-1</i> Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis |
| title_fullStr | Association between <i>Interleukin-1</i> Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis |
| title_full_unstemmed | Association between <i>Interleukin-1</i> Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis |
| title_short | Association between <i>Interleukin-1</i> Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis |
| title_sort | association between i interleukin 1 i polymorphisms and susceptibility to dental peri implant disease a meta analysis |
| topic | peri-implant disease peri-implantitis bone loss polymorphism <i>interleukin−1</i> |
| url | https://www.mdpi.com/2076-0817/10/12/1600 |
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