Distinct functions and transcriptional signatures in orally induced regulatory T cell populations

Distinct functions and transcriptional signatures in orally induced regulatory T cell populations

Oral administration of antigen induces regulatory T cells (Treg) that can not only control local immune responses in the small intestine, but also traffic to the central immune system to deliver systemic suppression. Employing murine models of the inherited bleeding disorder hemophilia, we find that...

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Bibliographic Details
Main Authors: Moanaro Biswas, Kaman So, Thais B. Bertolini, Preethi Krishnan, Jyoti Rana, Maite Muñoz-Melero, Farooq Syed, Sandeep R. P. Kumar, Hongyu Gao, Xiaoling Xuei, Cox Terhorst, Henry Daniell, Sha Cao, Roland W. Herzog
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
FoxP3+ regulatory T cells
latency associated peptide (LAP)
oral tolerance
antidrug antibodies (ADA)
single cell RNA and transcriptome sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1278184/full

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