ReadZS detects cell type-specific and developmentally regulated RNA processing programs in single-cell RNA-seq

ReadZS detects cell type-specific and developmentally regulated RNA processing programs in single-cell RNA-seq

Abstract RNA processing, including splicing and alternative polyadenylation, is crucial to gene function and regulation, but methods to detect RNA processing from single-cell RNA sequencing data are limited by reliance on pre-existing annotations, peak calling heuristics, and collapsing measurements...

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Bibliographic Details
Main Authors: Elisabeth Meyer, Kaitlin Chaung, Roozbeh Dehghannasiri, Julia Salzman
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Genome Biology
Subjects:
scRNA-seq
Differential RNA processing
Alternative polyadenylation
Untranslated regions
Online Access:https://doi.org/10.1186/s13059-022-02795-8

Internet

https://doi.org/10.1186/s13059-022-02795-8

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