Pathological Complete Response following Neoadjuvant Chemotherapy in Invasive Ductal Carcinoma with Mammary Paget’s Disease: A Case Report
Mammary Paget’s disease is a rare malignancy. Mastectomy or breast-conserving surgery has been considered as the standard treatment, while there have been few reports of neoadjuvant chemotherapy (NAC). A 53-year-old woman with erythema and skin ulceration of the left breast was admitted to our insti...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-08-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/516762 |
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| author | Wataru Goto Shinichiro Kashiwagi Yuko Kawano Asuka Komoda Sae Ishihara Yuka Asano Tamami Morisaki Kosei Hirakawa Masaichi Ohira |
| author_facet | Wataru Goto Shinichiro Kashiwagi Yuko Kawano Asuka Komoda Sae Ishihara Yuka Asano Tamami Morisaki Kosei Hirakawa Masaichi Ohira |
| author_sort | Wataru Goto |
| collection | DOAJ |
| description | Mammary Paget’s disease is a rare malignancy. Mastectomy or breast-conserving surgery has been considered as the standard treatment, while there have been few reports of neoadjuvant chemotherapy (NAC). A 53-year-old woman with erythema and skin ulceration of the left breast was admitted to our institution. Breast examinations revealed left invasive ductal carcinoma (cT1bN0M0, cStage I), and a punch biopsy of the left mammary erythema indicated Paget’s disease (cTisN0M0, cStage0). The patient received NAC because of multiple lesions. Consequently, the breast tumor clinically disappeared, and the erythema improved. These outcomes made it easier to perform surgery (left mastectomy and sentinel node biopsy). Histopathological examination revealed no residual cancer cells in either the mammary gland or breast skin, and no metastasis was found in the sentinel lymph node. Therefore, NAC may be a useful treatment for mammary Paget’s disease. |
| first_indexed | 2024-12-13T22:11:46Z |
| format | Article |
| id | doaj.art-3060790426894d84a6df335b59427d38 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-13T22:11:46Z |
| publishDate | 2021-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-3060790426894d84a6df335b59427d382022-12-21T23:29:41ZengKarger PublishersCase Reports in Oncology1662-65752021-08-011421242124710.1159/000516762516762Pathological Complete Response following Neoadjuvant Chemotherapy in Invasive Ductal Carcinoma with Mammary Paget’s Disease: A Case ReportWataru Goto0Shinichiro Kashiwagi1Yuko Kawano2Asuka Komoda3Sae Ishihara4Yuka Asano5Tamami Morisaki6Kosei Hirakawa7Masaichi Ohira8Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, JapanMammary Paget’s disease is a rare malignancy. Mastectomy or breast-conserving surgery has been considered as the standard treatment, while there have been few reports of neoadjuvant chemotherapy (NAC). A 53-year-old woman with erythema and skin ulceration of the left breast was admitted to our institution. Breast examinations revealed left invasive ductal carcinoma (cT1bN0M0, cStage I), and a punch biopsy of the left mammary erythema indicated Paget’s disease (cTisN0M0, cStage0). The patient received NAC because of multiple lesions. Consequently, the breast tumor clinically disappeared, and the erythema improved. These outcomes made it easier to perform surgery (left mastectomy and sentinel node biopsy). Histopathological examination revealed no residual cancer cells in either the mammary gland or breast skin, and no metastasis was found in the sentinel lymph node. Therefore, NAC may be a useful treatment for mammary Paget’s disease.https://www.karger.com/Article/FullText/516762paget’s diseaseneoadjuvant chemotherapypathological complete responsebreast cancermammary tumor |
| spellingShingle | Wataru Goto Shinichiro Kashiwagi Yuko Kawano Asuka Komoda Sae Ishihara Yuka Asano Tamami Morisaki Kosei Hirakawa Masaichi Ohira Pathological Complete Response following Neoadjuvant Chemotherapy in Invasive Ductal Carcinoma with Mammary Paget’s Disease: A Case Report Case Reports in Oncology paget’s disease neoadjuvant chemotherapy pathological complete response breast cancer mammary tumor |
| title | Pathological Complete Response following Neoadjuvant Chemotherapy in Invasive Ductal Carcinoma with Mammary Paget’s Disease: A Case Report |
| title_full | Pathological Complete Response following Neoadjuvant Chemotherapy in Invasive Ductal Carcinoma with Mammary Paget’s Disease: A Case Report |
| title_fullStr | Pathological Complete Response following Neoadjuvant Chemotherapy in Invasive Ductal Carcinoma with Mammary Paget’s Disease: A Case Report |
| title_full_unstemmed | Pathological Complete Response following Neoadjuvant Chemotherapy in Invasive Ductal Carcinoma with Mammary Paget’s Disease: A Case Report |
| title_short | Pathological Complete Response following Neoadjuvant Chemotherapy in Invasive Ductal Carcinoma with Mammary Paget’s Disease: A Case Report |
| title_sort | pathological complete response following neoadjuvant chemotherapy in invasive ductal carcinoma with mammary paget s disease a case report |
| topic | paget’s disease neoadjuvant chemotherapy pathological complete response breast cancer mammary tumor |
| url | https://www.karger.com/Article/FullText/516762 |
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