The Role of Reactive Oxygen Species in Immunopathogenesis of Rheumatoid Arthritis
Rheumatoid arthritis is a disease associated with painful joints that affects approximately 1% of the population worldwide, and for which no effective cure is available. It is characterized by chronic joint inflammation and variable degrees of bone and cartilage erosion. Oxygen metabolism has an imp...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2008-12-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/219 |
| _version_ | 1811277671682801664 |
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| author | Mirshafiey Abbas Mohsenzadegan Monireh |
| author_facet | Mirshafiey Abbas Mohsenzadegan Monireh |
| author_sort | Mirshafiey Abbas |
| collection | DOAJ |
| description | Rheumatoid arthritis is a disease associated with painful joints that affects approximately 1% of the population worldwide, and for which no effective cure is available. It is characterized by chronic joint inflammation and variable degrees of bone and cartilage erosion. Oxygen metabolism has an important role in the pathogenesis of rheumatoid arthritis. Reactive oxygen species (ROS) are produced in many normal and abnormal processes in humans, including atheroma, asthma, joint diseases, aging, and cancer. TNF-α overproduction is thought to be the main contributor to increased ROS release in patients with RA. Increased ROS production leads to tissue damage associated with inflammation. The prevailing hypothesis that ROS promote inflammation was recently challenged when polymorphisms in Neutrophil cytosolic factor 1(Ncf1), that decrease oxidative burst, were shown to increase disease severity in mouse and rat arthritis models. It has been shown that oxygen radicals might also be important in controlling disease severity and reducing joint inflammation and connective tissue damage. In this review article, our aim is to clarify the role of ROS in immunopathogenesis of Rheumatoid arthritis. |
| first_indexed | 2024-04-13T00:20:58Z |
| format | Article |
| id | doaj.art-306166fbec294eb9abf441d0e8c0e708 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-04-13T00:20:58Z |
| publishDate | 2008-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-306166fbec294eb9abf441d0e8c0e7082022-12-22T03:10:46ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492008-12-0174219The Role of Reactive Oxygen Species in Immunopathogenesis of Rheumatoid ArthritisMirshafiey Abbas0Mohsenzadegan Monireh1Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, IrDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, IrRheumatoid arthritis is a disease associated with painful joints that affects approximately 1% of the population worldwide, and for which no effective cure is available. It is characterized by chronic joint inflammation and variable degrees of bone and cartilage erosion. Oxygen metabolism has an important role in the pathogenesis of rheumatoid arthritis. Reactive oxygen species (ROS) are produced in many normal and abnormal processes in humans, including atheroma, asthma, joint diseases, aging, and cancer. TNF-α overproduction is thought to be the main contributor to increased ROS release in patients with RA. Increased ROS production leads to tissue damage associated with inflammation. The prevailing hypothesis that ROS promote inflammation was recently challenged when polymorphisms in Neutrophil cytosolic factor 1(Ncf1), that decrease oxidative burst, were shown to increase disease severity in mouse and rat arthritis models. It has been shown that oxygen radicals might also be important in controlling disease severity and reducing joint inflammation and connective tissue damage. In this review article, our aim is to clarify the role of ROS in immunopathogenesis of Rheumatoid arthritis.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/219CIAImmunopathogenesisRheumatoid arthritisROS |
| spellingShingle | Mirshafiey Abbas Mohsenzadegan Monireh The Role of Reactive Oxygen Species in Immunopathogenesis of Rheumatoid Arthritis Iranian Journal of Allergy, Asthma and Immunology CIA Immunopathogenesis Rheumatoid arthritis ROS |
| title | The Role of Reactive Oxygen Species in Immunopathogenesis of Rheumatoid Arthritis |
| title_full | The Role of Reactive Oxygen Species in Immunopathogenesis of Rheumatoid Arthritis |
| title_fullStr | The Role of Reactive Oxygen Species in Immunopathogenesis of Rheumatoid Arthritis |
| title_full_unstemmed | The Role of Reactive Oxygen Species in Immunopathogenesis of Rheumatoid Arthritis |
| title_short | The Role of Reactive Oxygen Species in Immunopathogenesis of Rheumatoid Arthritis |
| title_sort | role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis |
| topic | CIA Immunopathogenesis Rheumatoid arthritis ROS |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/219 |
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