Altered Ca<sup>2+</sup> Homeostasis in Immune Cells during Aging: Role of Ion Channels
Aging is an unstoppable process and begins shortly after birth. Each cell of the organism is affected by the irreversible process, not only with equal density but also at varying ages and with different speed. Therefore, aging can also be understood as an adaptation to a continually changing cellula...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/1/110 |
| _version_ | 1797543621575049216 |
|---|---|
| author | Dorina Zöphel Chantal Hof Annette Lis |
| author_facet | Dorina Zöphel Chantal Hof Annette Lis |
| author_sort | Dorina Zöphel |
| collection | DOAJ |
| description | Aging is an unstoppable process and begins shortly after birth. Each cell of the organism is affected by the irreversible process, not only with equal density but also at varying ages and with different speed. Therefore, aging can also be understood as an adaptation to a continually changing cellular environment. One of these very prominent changes in age affects Ca<sup>2+</sup> signaling. Especially immune cells highly rely on Ca<sup>2+</sup>-dependent processes and a strictly regulated Ca<sup>2+</sup> homeostasis. The intricate patterns of impaired immune cell function may represent a deficit or compensatory mechanisms. Besides, altered immune function through Ca<sup>2+</sup> signaling can profoundly affect the development of age-related disease. This review attempts to summarize changes in Ca<sup>2+</sup> signaling due to channels and receptors in T cells and beyond in the context of aging. |
| first_indexed | 2024-03-10T13:48:13Z |
| format | Article |
| id | doaj.art-3064d0972f914f42bfef8ef8fdd9f824 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:48:13Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3064d0972f914f42bfef8ef8fdd9f8242023-11-21T02:26:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-0122111010.3390/ijms22010110Altered Ca<sup>2+</sup> Homeostasis in Immune Cells during Aging: Role of Ion ChannelsDorina Zöphel0Chantal Hof1Annette Lis2Center for Integrative Physiology and Molecular Medicine, Department of Biophysics, School of Medicine, Saarland University, 66421 Homburg, GermanyCenter for Integrative Physiology and Molecular Medicine, Department of Biophysics, School of Medicine, Saarland University, 66421 Homburg, GermanyCenter for Integrative Physiology and Molecular Medicine, Department of Biophysics, School of Medicine, Saarland University, 66421 Homburg, GermanyAging is an unstoppable process and begins shortly after birth. Each cell of the organism is affected by the irreversible process, not only with equal density but also at varying ages and with different speed. Therefore, aging can also be understood as an adaptation to a continually changing cellular environment. One of these very prominent changes in age affects Ca<sup>2+</sup> signaling. Especially immune cells highly rely on Ca<sup>2+</sup>-dependent processes and a strictly regulated Ca<sup>2+</sup> homeostasis. The intricate patterns of impaired immune cell function may represent a deficit or compensatory mechanisms. Besides, altered immune function through Ca<sup>2+</sup> signaling can profoundly affect the development of age-related disease. This review attempts to summarize changes in Ca<sup>2+</sup> signaling due to channels and receptors in T cells and beyond in the context of aging.https://www.mdpi.com/1422-0067/22/1/110calcium homeostasisagingT cellsT cell functioncalciumSTIM |
| spellingShingle | Dorina Zöphel Chantal Hof Annette Lis Altered Ca<sup>2+</sup> Homeostasis in Immune Cells during Aging: Role of Ion Channels International Journal of Molecular Sciences calcium homeostasis aging T cells T cell function calcium STIM |
| title | Altered Ca<sup>2+</sup> Homeostasis in Immune Cells during Aging: Role of Ion Channels |
| title_full | Altered Ca<sup>2+</sup> Homeostasis in Immune Cells during Aging: Role of Ion Channels |
| title_fullStr | Altered Ca<sup>2+</sup> Homeostasis in Immune Cells during Aging: Role of Ion Channels |
| title_full_unstemmed | Altered Ca<sup>2+</sup> Homeostasis in Immune Cells during Aging: Role of Ion Channels |
| title_short | Altered Ca<sup>2+</sup> Homeostasis in Immune Cells during Aging: Role of Ion Channels |
| title_sort | altered ca sup 2 sup homeostasis in immune cells during aging role of ion channels |
| topic | calcium homeostasis aging T cells T cell function calcium STIM |
| url | https://www.mdpi.com/1422-0067/22/1/110 |
| work_keys_str_mv | AT dorinazophel alteredcasup2suphomeostasisinimmunecellsduringagingroleofionchannels AT chantalhof alteredcasup2suphomeostasisinimmunecellsduringagingroleofionchannels AT annettelis alteredcasup2suphomeostasisinimmunecellsduringagingroleofionchannels |