Right ventricular 2D speckle-tracking echocardiography in children with osteosarcoma under chemotherapy
Abstract Background Cardiotoxicity from anthracyclin chemotherapy is a leading cause of death in patients with cancer. Therefore, left ventricular (LV) function is routinely assessed during protocol to detect cardiotoxicity; however, animal studies suggest that right ventricular (RV) function may be...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-11-01
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| Series: | The Egyptian Heart Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43044-019-0028-9 |
| _version_ | 1818935177826533376 |
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| author | Ibtsam Khairat Mohamed Khalfallah Aliaa Shaban Ibrahim Abu Farag Asmaa Elkady |
| author_facet | Ibtsam Khairat Mohamed Khalfallah Aliaa Shaban Ibrahim Abu Farag Asmaa Elkady |
| author_sort | Ibtsam Khairat |
| collection | DOAJ |
| description | Abstract Background Cardiotoxicity from anthracyclin chemotherapy is a leading cause of death in patients with cancer. Therefore, left ventricular (LV) function is routinely assessed during protocol to detect cardiotoxicity; however, animal studies suggest that right ventricular (RV) function may be also impaired. So, our objective was to investigate the incidence of RV dysfunction in children with osteosarcoma receiving anthracyclines and to highlight the role of 2D STE in early detection of RV dysfunction. Results RV function was affected by anthacyclines through direct cardiotoxic effect on RV myocardium without simultaneous derangement of LV function. Furthermore, there is a direct proportion between the incidence of RV dysfunction and the cumulative dose of anthracyclines. At the first echo follow-up at 10th week, 7 patients had impaired RV GLS in comparison to baseline study. At 20th week, the number of patients with impaired RV strain increased to 10. At 29th week, it reaches 12 patients. This effect was early detected by RV 2DSTE before adversely affecting TAPSE and FAC. The incidence of RV dysfunction from anthracyclines was around 12%, and the recovery rate was around 8% in 3 months after completion of chemotherapy. Conclusion RV 2DSTE is the best modality to detect early affection of RV function in comparison with other modalities. RV function decreases early even before derangement of LV function. Accordingly, it should be assessed separately in all patients who received anthracyclines even without evident LV affection. |
| first_indexed | 2024-12-20T05:16:02Z |
| format | Article |
| id | doaj.art-30656af0722a495f83c5128eb975a64a |
| institution | Directory Open Access Journal |
| issn | 2090-911X |
| language | English |
| last_indexed | 2024-12-20T05:16:02Z |
| publishDate | 2019-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-30656af0722a495f83c5128eb975a64a2022-12-21T19:52:09ZengSpringerOpenThe Egyptian Heart Journal2090-911X2019-11-017111810.1186/s43044-019-0028-9Right ventricular 2D speckle-tracking echocardiography in children with osteosarcoma under chemotherapyIbtsam Khairat0Mohamed Khalfallah1Aliaa Shaban2Ibrahim Abu Farag3Asmaa Elkady4Cardiology Department, Faculty of Medicine, Tanta UniversityCardiology Department, Faculty of Medicine, Tanta UniversityCardiology Department, Faculty of Medicine, Tanta UniversityPediatric Deparment, Faculty of Medicine, Al_Azhar universityOncology Department, Faculty of Medicine, Tanta UniversityAbstract Background Cardiotoxicity from anthracyclin chemotherapy is a leading cause of death in patients with cancer. Therefore, left ventricular (LV) function is routinely assessed during protocol to detect cardiotoxicity; however, animal studies suggest that right ventricular (RV) function may be also impaired. So, our objective was to investigate the incidence of RV dysfunction in children with osteosarcoma receiving anthracyclines and to highlight the role of 2D STE in early detection of RV dysfunction. Results RV function was affected by anthacyclines through direct cardiotoxic effect on RV myocardium without simultaneous derangement of LV function. Furthermore, there is a direct proportion between the incidence of RV dysfunction and the cumulative dose of anthracyclines. At the first echo follow-up at 10th week, 7 patients had impaired RV GLS in comparison to baseline study. At 20th week, the number of patients with impaired RV strain increased to 10. At 29th week, it reaches 12 patients. This effect was early detected by RV 2DSTE before adversely affecting TAPSE and FAC. The incidence of RV dysfunction from anthracyclines was around 12%, and the recovery rate was around 8% in 3 months after completion of chemotherapy. Conclusion RV 2DSTE is the best modality to detect early affection of RV function in comparison with other modalities. RV function decreases early even before derangement of LV function. Accordingly, it should be assessed separately in all patients who received anthracyclines even without evident LV affection.http://link.springer.com/article/10.1186/s43044-019-0028-9Right ventricle, speckle-tracking echocardiographyOsteosarcomaChemotherapy |
| spellingShingle | Ibtsam Khairat Mohamed Khalfallah Aliaa Shaban Ibrahim Abu Farag Asmaa Elkady Right ventricular 2D speckle-tracking echocardiography in children with osteosarcoma under chemotherapy The Egyptian Heart Journal Right ventricle, speckle-tracking echocardiography Osteosarcoma Chemotherapy |
| title | Right ventricular 2D speckle-tracking echocardiography in children with osteosarcoma under chemotherapy |
| title_full | Right ventricular 2D speckle-tracking echocardiography in children with osteosarcoma under chemotherapy |
| title_fullStr | Right ventricular 2D speckle-tracking echocardiography in children with osteosarcoma under chemotherapy |
| title_full_unstemmed | Right ventricular 2D speckle-tracking echocardiography in children with osteosarcoma under chemotherapy |
| title_short | Right ventricular 2D speckle-tracking echocardiography in children with osteosarcoma under chemotherapy |
| title_sort | right ventricular 2d speckle tracking echocardiography in children with osteosarcoma under chemotherapy |
| topic | Right ventricle, speckle-tracking echocardiography Osteosarcoma Chemotherapy |
| url | http://link.springer.com/article/10.1186/s43044-019-0028-9 |
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