The aryl hydrocarbon receptor as a model PAS sensor
Proteins containing PER-ARNT-SIM (PAS) domains are commonly associated with environmental adaptation in a variety of organisms. The PAS domain is found in proteins throughout Archaea, Bacteria, and Eukarya and often binds small-molecules, supports protein-protein interactions, and transduces input s...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750021002018 |
| _version_ | 1811201831023411200 |
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| author | Emmanuel Vazquez-Rivera Brenda L. Rojas Jessica C. Parrott Anna L. Shen Yongna Xing Patrick R. Carney Christopher A. Bradfield |
| author_facet | Emmanuel Vazquez-Rivera Brenda L. Rojas Jessica C. Parrott Anna L. Shen Yongna Xing Patrick R. Carney Christopher A. Bradfield |
| author_sort | Emmanuel Vazquez-Rivera |
| collection | DOAJ |
| description | Proteins containing PER-ARNT-SIM (PAS) domains are commonly associated with environmental adaptation in a variety of organisms. The PAS domain is found in proteins throughout Archaea, Bacteria, and Eukarya and often binds small-molecules, supports protein-protein interactions, and transduces input signals to mediate an adaptive physiological response. Signaling events mediated by PAS sensors can occur through induced phosphorelays or genomic events that are often dependent upon PAS domain interactions. In this perspective, we briefly discuss the diversity of PAS domain containing proteins, with particular emphasis on the prototype member, the aryl hydrocarbon receptor (AHR). This ligand-activated transcription factor acts as a sensor of the chemical environment in humans and many chordates. We conclude with the idea that since mammalian PAS proteins often act through PAS-PAS dimers, undocumented interactions of this type may link biological processes that we currently think of as independent. To support this idea, we present a framework to guide future experiments aimed at fully elucidating the spectrum of PAS-PAS interactions with an eye towards understanding how they might influence environmental sensing in human and wildlife populations. |
| first_indexed | 2024-04-12T02:28:33Z |
| format | Article |
| id | doaj.art-30663714268b47fd894efbc2d346cd02 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-04-12T02:28:33Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-30663714268b47fd894efbc2d346cd022022-12-22T03:51:52ZengElsevierToxicology Reports2214-75002022-01-019111The aryl hydrocarbon receptor as a model PAS sensorEmmanuel Vazquez-Rivera0Brenda L. Rojas1Jessica C. Parrott2Anna L. Shen3Yongna Xing4Patrick R. Carney5Christopher A. Bradfield6Molecular and Environmental Toxicology Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United StatesMolecular and Environmental Toxicology Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United StatesMolecular and Environmental Toxicology Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United StatesMolecular and Environmental Toxicology Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United States; McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United StatesMolecular and Environmental Toxicology Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United States; McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United StatesMolecular and Environmental Toxicology Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United States; McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United StatesMolecular and Environmental Toxicology Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United States; McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, United States; Corresponding author at: McArdle Laboratory for Cancer Research, 1400 University Ave., Madison, WI 53706, United States.Proteins containing PER-ARNT-SIM (PAS) domains are commonly associated with environmental adaptation in a variety of organisms. The PAS domain is found in proteins throughout Archaea, Bacteria, and Eukarya and often binds small-molecules, supports protein-protein interactions, and transduces input signals to mediate an adaptive physiological response. Signaling events mediated by PAS sensors can occur through induced phosphorelays or genomic events that are often dependent upon PAS domain interactions. In this perspective, we briefly discuss the diversity of PAS domain containing proteins, with particular emphasis on the prototype member, the aryl hydrocarbon receptor (AHR). This ligand-activated transcription factor acts as a sensor of the chemical environment in humans and many chordates. We conclude with the idea that since mammalian PAS proteins often act through PAS-PAS dimers, undocumented interactions of this type may link biological processes that we currently think of as independent. To support this idea, we present a framework to guide future experiments aimed at fully elucidating the spectrum of PAS-PAS interactions with an eye towards understanding how they might influence environmental sensing in human and wildlife populations.http://www.sciencedirect.com/science/article/pii/S2214750021002018Aryl hydrocarbon receptorPAS proteinsEnvironmental sensors |
| spellingShingle | Emmanuel Vazquez-Rivera Brenda L. Rojas Jessica C. Parrott Anna L. Shen Yongna Xing Patrick R. Carney Christopher A. Bradfield The aryl hydrocarbon receptor as a model PAS sensor Toxicology Reports Aryl hydrocarbon receptor PAS proteins Environmental sensors |
| title | The aryl hydrocarbon receptor as a model PAS sensor |
| title_full | The aryl hydrocarbon receptor as a model PAS sensor |
| title_fullStr | The aryl hydrocarbon receptor as a model PAS sensor |
| title_full_unstemmed | The aryl hydrocarbon receptor as a model PAS sensor |
| title_short | The aryl hydrocarbon receptor as a model PAS sensor |
| title_sort | aryl hydrocarbon receptor as a model pas sensor |
| topic | Aryl hydrocarbon receptor PAS proteins Environmental sensors |
| url | http://www.sciencedirect.com/science/article/pii/S2214750021002018 |
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