A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women
The impact of obesity could differ according to menopausal status since women undergo significant physiologic and metabolic changes due to menopause. We investigated the association between various major obesity indicators and the risk of impaired fasting glucose (IFG) according to menopausal status...
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MDPI AG
2022-05-01
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author | Myung Ji Nam Hyunjin Kim Yeon Joo Choi Kyung-Hwan Cho Seon Mee Kim Yong-Kyun Roh Kyungdo Han Jin-Hyung Jung Yong-Gyu Park Joo-Hyun Park Do-Hoon Kim |
author_facet | Myung Ji Nam Hyunjin Kim Yeon Joo Choi Kyung-Hwan Cho Seon Mee Kim Yong-Kyun Roh Kyungdo Han Jin-Hyung Jung Yong-Gyu Park Joo-Hyun Park Do-Hoon Kim |
author_sort | Myung Ji Nam |
collection | DOAJ |
description | The impact of obesity could differ according to menopausal status since women undergo significant physiologic and metabolic changes due to menopause. We investigated the association between various major obesity indicators and the risk of impaired fasting glucose (IFG) according to menopausal status using nationally representative data. A total of 571,286 premenopausal and 519,561 postmenopausal women who underwent both Korean National Health Insurance Service (NHIS) cancer screening in 2009 and health check-ups in 2017 were analyzed. Multivariate logistic regression analyses were used to assess the effect of independent variables of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) in 2009, on dependent variable IFG in 2017. After adjusting for potential confounders, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of developing IFG were analyzed. In the premenopausal group, the OR of obese BMI (≥25 kg/m<sup>2</sup>, <30 kg/m<sup>2</sup>) women was increased to 2.228 (95% CI: 2.139–2.321) compared to the normal BMI (≥18.5, <23 kg/m<sup>2</sup>) women as a reference. In the postmenopausal group, there was also a higher OR of 1.778 (95% CI: 1.715–1.843) in the obese BMI women compared to the normal group. A similar association of increasing ORs for IFG was shown in both groups when stratified by WC and WHtR. This nationwide study revealed that obesity and abdominal obesity, defined by various obesity indicators, consistently increased odds of acquiring IFG after 8 years in both pre- and postmenopausal groups, with the association being more robust in the premenopausal group. Our findings suggest that weight management and lifestyle modification may require more attention in premenopausal women. |
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language | English |
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spelling | doaj.art-3066f763e406463e97e90680b4c33a5d2023-11-23T11:34:58ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011110279510.3390/jcm11102795A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal WomenMyung Ji Nam0Hyunjin Kim1Yeon Joo Choi2Kyung-Hwan Cho3Seon Mee Kim4Yong-Kyun Roh5Kyungdo Han6Jin-Hyung Jung7Yong-Gyu Park8Joo-Hyun Park9Do-Hoon Kim10Department of Family Medicine, Korea University Ansan Hospital, College of Medicine, Ansan 15355, KoreaDepartment of Family Medicine, Korea University Ansan Hospital, College of Medicine, Ansan 15355, KoreaDepartment of Family Medicine, Korea University Ansan Hospital, College of Medicine, Ansan 15355, KoreaDepartment of Family Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, KoreaDepartment of Family Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul 08308, KoreaDepartment of Family Medicine, Hallym University Medical Center, Hallym University College of Medicine, Seoul 07441, KoreaDepartment of Statistics and Actuarial Science, Soongsil University, Seoul 06978, KoreaDepartment of Biostatistics, Catholic University College of Medicine, Seoul 06591, KoreaDepartment of Biostatistics, Catholic University College of Medicine, Seoul 06591, KoreaDepartment of Family Medicine, Korea University Ansan Hospital, College of Medicine, Ansan 15355, KoreaDepartment of Family Medicine, Korea University Ansan Hospital, College of Medicine, Ansan 15355, KoreaThe impact of obesity could differ according to menopausal status since women undergo significant physiologic and metabolic changes due to menopause. We investigated the association between various major obesity indicators and the risk of impaired fasting glucose (IFG) according to menopausal status using nationally representative data. A total of 571,286 premenopausal and 519,561 postmenopausal women who underwent both Korean National Health Insurance Service (NHIS) cancer screening in 2009 and health check-ups in 2017 were analyzed. Multivariate logistic regression analyses were used to assess the effect of independent variables of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) in 2009, on dependent variable IFG in 2017. After adjusting for potential confounders, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of developing IFG were analyzed. In the premenopausal group, the OR of obese BMI (≥25 kg/m<sup>2</sup>, <30 kg/m<sup>2</sup>) women was increased to 2.228 (95% CI: 2.139–2.321) compared to the normal BMI (≥18.5, <23 kg/m<sup>2</sup>) women as a reference. In the postmenopausal group, there was also a higher OR of 1.778 (95% CI: 1.715–1.843) in the obese BMI women compared to the normal group. A similar association of increasing ORs for IFG was shown in both groups when stratified by WC and WHtR. This nationwide study revealed that obesity and abdominal obesity, defined by various obesity indicators, consistently increased odds of acquiring IFG after 8 years in both pre- and postmenopausal groups, with the association being more robust in the premenopausal group. Our findings suggest that weight management and lifestyle modification may require more attention in premenopausal women.https://www.mdpi.com/2077-0383/11/10/2795abdominal obesityimpaired fasting glucosemenopause |
spellingShingle | Myung Ji Nam Hyunjin Kim Yeon Joo Choi Kyung-Hwan Cho Seon Mee Kim Yong-Kyun Roh Kyungdo Han Jin-Hyung Jung Yong-Gyu Park Joo-Hyun Park Do-Hoon Kim A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women Journal of Clinical Medicine abdominal obesity impaired fasting glucose menopause |
title | A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women |
title_full | A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women |
title_fullStr | A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women |
title_full_unstemmed | A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women |
title_short | A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women |
title_sort | longitudinal retrospective observational study on obesity indicators and the risk of impaired fasting glucose in pre and postmenopausal women |
topic | abdominal obesity impaired fasting glucose menopause |
url | https://www.mdpi.com/2077-0383/11/10/2795 |
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