A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women

The impact of obesity could differ according to menopausal status since women undergo significant physiologic and metabolic changes due to menopause. We investigated the association between various major obesity indicators and the risk of impaired fasting glucose (IFG) according to menopausal status...

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Main Authors: Myung Ji Nam, Hyunjin Kim, Yeon Joo Choi, Kyung-Hwan Cho, Seon Mee Kim, Yong-Kyun Roh, Kyungdo Han, Jin-Hyung Jung, Yong-Gyu Park, Joo-Hyun Park, Do-Hoon Kim
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Journal of Clinical Medicine
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Online Access:https://www.mdpi.com/2077-0383/11/10/2795
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author Myung Ji Nam
Hyunjin Kim
Yeon Joo Choi
Kyung-Hwan Cho
Seon Mee Kim
Yong-Kyun Roh
Kyungdo Han
Jin-Hyung Jung
Yong-Gyu Park
Joo-Hyun Park
Do-Hoon Kim
author_facet Myung Ji Nam
Hyunjin Kim
Yeon Joo Choi
Kyung-Hwan Cho
Seon Mee Kim
Yong-Kyun Roh
Kyungdo Han
Jin-Hyung Jung
Yong-Gyu Park
Joo-Hyun Park
Do-Hoon Kim
author_sort Myung Ji Nam
collection DOAJ
description The impact of obesity could differ according to menopausal status since women undergo significant physiologic and metabolic changes due to menopause. We investigated the association between various major obesity indicators and the risk of impaired fasting glucose (IFG) according to menopausal status using nationally representative data. A total of 571,286 premenopausal and 519,561 postmenopausal women who underwent both Korean National Health Insurance Service (NHIS) cancer screening in 2009 and health check-ups in 2017 were analyzed. Multivariate logistic regression analyses were used to assess the effect of independent variables of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) in 2009, on dependent variable IFG in 2017. After adjusting for potential confounders, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of developing IFG were analyzed. In the premenopausal group, the OR of obese BMI (≥25 kg/m<sup>2</sup>, <30 kg/m<sup>2</sup>) women was increased to 2.228 (95% CI: 2.139–2.321) compared to the normal BMI (≥18.5, <23 kg/m<sup>2</sup>) women as a reference. In the postmenopausal group, there was also a higher OR of 1.778 (95% CI: 1.715–1.843) in the obese BMI women compared to the normal group. A similar association of increasing ORs for IFG was shown in both groups when stratified by WC and WHtR. This nationwide study revealed that obesity and abdominal obesity, defined by various obesity indicators, consistently increased odds of acquiring IFG after 8 years in both pre- and postmenopausal groups, with the association being more robust in the premenopausal group. Our findings suggest that weight management and lifestyle modification may require more attention in premenopausal women.
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spelling doaj.art-3066f763e406463e97e90680b4c33a5d2023-11-23T11:34:58ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011110279510.3390/jcm11102795A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal WomenMyung Ji Nam0Hyunjin Kim1Yeon Joo Choi2Kyung-Hwan Cho3Seon Mee Kim4Yong-Kyun Roh5Kyungdo Han6Jin-Hyung Jung7Yong-Gyu Park8Joo-Hyun Park9Do-Hoon Kim10Department of Family Medicine, Korea University Ansan Hospital, College of Medicine, Ansan 15355, KoreaDepartment of Family Medicine, Korea University Ansan Hospital, College of Medicine, Ansan 15355, KoreaDepartment of Family Medicine, Korea University Ansan Hospital, College of Medicine, Ansan 15355, KoreaDepartment of Family Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, KoreaDepartment of Family Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul 08308, KoreaDepartment of Family Medicine, Hallym University Medical Center, Hallym University College of Medicine, Seoul 07441, KoreaDepartment of Statistics and Actuarial Science, Soongsil University, Seoul 06978, KoreaDepartment of Biostatistics, Catholic University College of Medicine, Seoul 06591, KoreaDepartment of Biostatistics, Catholic University College of Medicine, Seoul 06591, KoreaDepartment of Family Medicine, Korea University Ansan Hospital, College of Medicine, Ansan 15355, KoreaDepartment of Family Medicine, Korea University Ansan Hospital, College of Medicine, Ansan 15355, KoreaThe impact of obesity could differ according to menopausal status since women undergo significant physiologic and metabolic changes due to menopause. We investigated the association between various major obesity indicators and the risk of impaired fasting glucose (IFG) according to menopausal status using nationally representative data. A total of 571,286 premenopausal and 519,561 postmenopausal women who underwent both Korean National Health Insurance Service (NHIS) cancer screening in 2009 and health check-ups in 2017 were analyzed. Multivariate logistic regression analyses were used to assess the effect of independent variables of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) in 2009, on dependent variable IFG in 2017. After adjusting for potential confounders, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of developing IFG were analyzed. In the premenopausal group, the OR of obese BMI (≥25 kg/m<sup>2</sup>, <30 kg/m<sup>2</sup>) women was increased to 2.228 (95% CI: 2.139–2.321) compared to the normal BMI (≥18.5, <23 kg/m<sup>2</sup>) women as a reference. In the postmenopausal group, there was also a higher OR of 1.778 (95% CI: 1.715–1.843) in the obese BMI women compared to the normal group. A similar association of increasing ORs for IFG was shown in both groups when stratified by WC and WHtR. This nationwide study revealed that obesity and abdominal obesity, defined by various obesity indicators, consistently increased odds of acquiring IFG after 8 years in both pre- and postmenopausal groups, with the association being more robust in the premenopausal group. Our findings suggest that weight management and lifestyle modification may require more attention in premenopausal women.https://www.mdpi.com/2077-0383/11/10/2795abdominal obesityimpaired fasting glucosemenopause
spellingShingle Myung Ji Nam
Hyunjin Kim
Yeon Joo Choi
Kyung-Hwan Cho
Seon Mee Kim
Yong-Kyun Roh
Kyungdo Han
Jin-Hyung Jung
Yong-Gyu Park
Joo-Hyun Park
Do-Hoon Kim
A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women
Journal of Clinical Medicine
abdominal obesity
impaired fasting glucose
menopause
title A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women
title_full A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women
title_fullStr A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women
title_full_unstemmed A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women
title_short A Longitudinal Retrospective Observational Study on Obesity Indicators and the Risk of Impaired Fasting Glucose in Pre- and Postmenopausal Women
title_sort longitudinal retrospective observational study on obesity indicators and the risk of impaired fasting glucose in pre and postmenopausal women
topic abdominal obesity
impaired fasting glucose
menopause
url https://www.mdpi.com/2077-0383/11/10/2795
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