Features of model coronaviruses distribution in feline organs and tissues in the context of COVID-19 pathogenesis study
To date, the reisreason to believe that, unlike classical a cuterespiratory virusinfections caused by adenoviruses, rhinoviruses, orthomyxoviruses, COVID-19 behaves completely differently. Firstly, the pathological process esare likely to be immune-mediated and the immun esystem quites lowly ensures...
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| Format: | Article |
| Language: | English |
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Da Vinci Media
2023-03-01
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| Series: | Ветеринария сегодня |
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| Online Access: | https://veterinary.arriah.ru/jour/article/view/707 |
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| author | V. N. Afonyushkin O. E. Sysoeva O. S. Kozlova D. V. Shamovskaya |
| author_facet | V. N. Afonyushkin O. E. Sysoeva O. S. Kozlova D. V. Shamovskaya |
| author_sort | V. N. Afonyushkin |
| collection | DOAJ |
| description | To date, the reisreason to believe that, unlike classical a cuterespiratory virusinfections caused by adenoviruses, rhinoviruses, orthomyxoviruses, COVID-19 behaves completely differently. Firstly, the pathological process esare likely to be immune-mediated and the immun esystem quites lowly ensurest heelimination of the virus from the organism. Secondly, the dynamics of the diseases ymptom development and the duration of intestinal virusshedding after recovery give reason to believe that theSARS-CoV-2 infection is mainly localizedin the intestine. A possible reason isthat in the presence of proteolyticenzymes, viral particlesmature, hydrophilic aminoacids are removed from the surface of the virion, making it more hydrophobic and able to ad here to cells due to hydrophobic interactions. The presence of the ACE2 recept or mainly in the enterocytes of the ileumdoes not exclude the accumulation of coronavirusin lymphocytes, given that there are more lymphocytes in the gastrointestinal tract than anywhere else, this fact can beconsidered as another justification for the predominant accumulation of coronaviruses, including SARS-CoV-2 in the intestine. A distinctive feature of feline coronavirus infection and, in particular, infectious feline peritonitis, from human COVID-19 infection was considered to be the presence of effusion peritonitis as the main complication leading to death, while respiratory and card iovascular in sufficiency is more characteristic for humans. Never the less, cases of serous peritonitis in humans infected with COVID-19 have already been described. In the context of the analyzed model, theclinical case describedin the study allows principal possibility of exacerbation of chronic coronavirus infection in caseof re-infection (superinfection) and development of apredominantlylocal infection. |
| first_indexed | 2024-03-09T02:49:01Z |
| format | Article |
| id | doaj.art-306717801e9a45399dd0034bb62dbfaa |
| institution | Directory Open Access Journal |
| issn | 2304-196X 2658-6959 |
| language | English |
| last_indexed | 2024-04-24T13:58:41Z |
| publishDate | 2023-03-01 |
| publisher | Da Vinci Media |
| record_format | Article |
| series | Ветеринария сегодня |
| spelling | doaj.art-306717801e9a45399dd0034bb62dbfaa2024-04-03T12:48:51ZengDa Vinci MediaВетеринария сегодня2304-196X2658-69592023-03-01121384410.29326/2304-196X-2023-12-1-38-44601Features of model coronaviruses distribution in feline organs and tissues in the context of COVID-19 pathogenesis studyV. N. Afonyushkin0O. E. Sysoeva1O. S. Kozlova2D. V. Shamovskaya3FSSFEI HE “Novosibirsk State Agricultural University” (FSSFEI HE Novosibirsk SAU); Siberian Federal Research Center of Agrobiotechnologies of the Russian Academy of Sciences (SFSCA RAS); Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences (ICBFM SB RAS)FSSFEI HE “Novosibirsk State Agricultural University” (FSSFEI HE Novosibirsk SAU)FSSFEI HE “Novosibirsk State Agricultural University” (FSSFEI HE Novosibirsk SAU)Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences (ICBFM SB RAS)To date, the reisreason to believe that, unlike classical a cuterespiratory virusinfections caused by adenoviruses, rhinoviruses, orthomyxoviruses, COVID-19 behaves completely differently. Firstly, the pathological process esare likely to be immune-mediated and the immun esystem quites lowly ensurest heelimination of the virus from the organism. Secondly, the dynamics of the diseases ymptom development and the duration of intestinal virusshedding after recovery give reason to believe that theSARS-CoV-2 infection is mainly localizedin the intestine. A possible reason isthat in the presence of proteolyticenzymes, viral particlesmature, hydrophilic aminoacids are removed from the surface of the virion, making it more hydrophobic and able to ad here to cells due to hydrophobic interactions. The presence of the ACE2 recept or mainly in the enterocytes of the ileumdoes not exclude the accumulation of coronavirusin lymphocytes, given that there are more lymphocytes in the gastrointestinal tract than anywhere else, this fact can beconsidered as another justification for the predominant accumulation of coronaviruses, including SARS-CoV-2 in the intestine. A distinctive feature of feline coronavirus infection and, in particular, infectious feline peritonitis, from human COVID-19 infection was considered to be the presence of effusion peritonitis as the main complication leading to death, while respiratory and card iovascular in sufficiency is more characteristic for humans. Never the less, cases of serous peritonitis in humans infected with COVID-19 have already been described. In the context of the analyzed model, theclinical case describedin the study allows principal possibility of exacerbation of chronic coronavirus infection in caseof re-infection (superinfection) and development of apredominantlylocal infection.https://veterinary.arriah.ru/jour/article/view/707catscoronaviruscovid-19fcovsars-cov-2pathoanatomical examinationhistological examination |
| spellingShingle | V. N. Afonyushkin O. E. Sysoeva O. S. Kozlova D. V. Shamovskaya Features of model coronaviruses distribution in feline organs and tissues in the context of COVID-19 pathogenesis study Ветеринария сегодня cats coronavirus covid-19 fcov sars-cov-2 pathoanatomical examination histological examination |
| title | Features of model coronaviruses distribution in feline organs and tissues in the context of COVID-19 pathogenesis study |
| title_full | Features of model coronaviruses distribution in feline organs and tissues in the context of COVID-19 pathogenesis study |
| title_fullStr | Features of model coronaviruses distribution in feline organs and tissues in the context of COVID-19 pathogenesis study |
| title_full_unstemmed | Features of model coronaviruses distribution in feline organs and tissues in the context of COVID-19 pathogenesis study |
| title_short | Features of model coronaviruses distribution in feline organs and tissues in the context of COVID-19 pathogenesis study |
| title_sort | features of model coronaviruses distribution in feline organs and tissues in the context of covid 19 pathogenesis study |
| topic | cats coronavirus covid-19 fcov sars-cov-2 pathoanatomical examination histological examination |
| url | https://veterinary.arriah.ru/jour/article/view/707 |
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