Glycemic Control during Pregnancy—A Predictor of Vitamin C Status at Labor in Type 1 Diabetic Women?
Several experimental studies have suggested that vitamin C (vitC) deficiency during pregnancy may be detrimental to fetal development, and observational studies have shown that vitC status is lower during pregnancy and in people with diabetes. A cross-sectional study in pregnant type 1 diabetic wome...
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| Format: | Article |
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MDPI AG
2019-05-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/6/153 |
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| author | Bente Juhl Finn F. Lauszus Jens Lykkesfeldt |
| author_facet | Bente Juhl Finn F. Lauszus Jens Lykkesfeldt |
| author_sort | Bente Juhl |
| collection | DOAJ |
| description | Several experimental studies have suggested that vitamin C (vitC) deficiency during pregnancy may be detrimental to fetal development, and observational studies have shown that vitC status is lower during pregnancy and in people with diabetes. A cross-sectional study in pregnant type 1 diabetic women found that poor maternal vitC status was a significant predictor for obstetric complications of pregnancy when measured within four weeks before labor. The plasma vitC concentration was significantly negatively correlated to HbA1c, the biomarker of glycemic control well-known to be associated with the outcome of the diabetic pregnancy. Here, we evaluated HbA1c during pregnancy in relation to the measured vitC levels in late pregnancy based on data from 46 women from the same cohort. Regression analysis showed that HbA1c of first trimester, the combined mean HbA1c of first and second trimester, mean HbA1c of the whole pregnancy (first, second and third trimester combined), and HbA1c of third trimester alone were all associated with vitC in late pregnancy (<i>p</i> = 0.03, <i>n</i> = 45; <i>p</i> = 0.034, <i>n</i> = 43; <i>p</i> = 0.017, <i>n</i> = 42; and <i>p</i> = 0.008, <i>n</i> = 46, respectively). In third trimester, when adjusted for creatinine clearance, the association between vitC and HbA1c persisted (<i>p</i> = 0.029). Women in third trimester with HbA1c above 7.0% had an increased risk of having poor vitC status compared to women with HbA1c below this level (11 out of 21 vs. 2 out of 25 women, <i>p</i> < 0.001). The results suggest that high HbA1c is associated with poor maternal vitC status and potentially inadequate supply of vitC for the neonate. HbA1c may thus be a relevant substitute biomarker for identifying pregnant women who might benefit from vitC supplementation. |
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| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T07:50:35Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
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| series | Antioxidants |
| spelling | doaj.art-30677080927d412aa937aa23ceebd8482023-09-02T20:36:20ZengMDPI AGAntioxidants2076-39212019-05-018615310.3390/antiox8060153antiox8060153Glycemic Control during Pregnancy—A Predictor of Vitamin C Status at Labor in Type 1 Diabetic Women?Bente Juhl0Finn F. Lauszus1Jens Lykkesfeldt2Medical Department, Aarhus University Hospital, 8200 Aarhus, DenmarkGynecology & Obstetrics Department, Herning Hospital, 7400 Herning, DenmarkFaculty of Health and Medical Sciences, University of Copenhagen, 2200 København N, DenmarkSeveral experimental studies have suggested that vitamin C (vitC) deficiency during pregnancy may be detrimental to fetal development, and observational studies have shown that vitC status is lower during pregnancy and in people with diabetes. A cross-sectional study in pregnant type 1 diabetic women found that poor maternal vitC status was a significant predictor for obstetric complications of pregnancy when measured within four weeks before labor. The plasma vitC concentration was significantly negatively correlated to HbA1c, the biomarker of glycemic control well-known to be associated with the outcome of the diabetic pregnancy. Here, we evaluated HbA1c during pregnancy in relation to the measured vitC levels in late pregnancy based on data from 46 women from the same cohort. Regression analysis showed that HbA1c of first trimester, the combined mean HbA1c of first and second trimester, mean HbA1c of the whole pregnancy (first, second and third trimester combined), and HbA1c of third trimester alone were all associated with vitC in late pregnancy (<i>p</i> = 0.03, <i>n</i> = 45; <i>p</i> = 0.034, <i>n</i> = 43; <i>p</i> = 0.017, <i>n</i> = 42; and <i>p</i> = 0.008, <i>n</i> = 46, respectively). In third trimester, when adjusted for creatinine clearance, the association between vitC and HbA1c persisted (<i>p</i> = 0.029). Women in third trimester with HbA1c above 7.0% had an increased risk of having poor vitC status compared to women with HbA1c below this level (11 out of 21 vs. 2 out of 25 women, <i>p</i> < 0.001). The results suggest that high HbA1c is associated with poor maternal vitC status and potentially inadequate supply of vitC for the neonate. HbA1c may thus be a relevant substitute biomarker for identifying pregnant women who might benefit from vitC supplementation.https://www.mdpi.com/2076-3921/8/6/153type 1 diabetes mellitusHbA1cpregnancyvitamin Ccohort study |
| spellingShingle | Bente Juhl Finn F. Lauszus Jens Lykkesfeldt Glycemic Control during Pregnancy—A Predictor of Vitamin C Status at Labor in Type 1 Diabetic Women? Antioxidants type 1 diabetes mellitus HbA1c pregnancy vitamin C cohort study |
| title | Glycemic Control during Pregnancy—A Predictor of Vitamin C Status at Labor in Type 1 Diabetic Women? |
| title_full | Glycemic Control during Pregnancy—A Predictor of Vitamin C Status at Labor in Type 1 Diabetic Women? |
| title_fullStr | Glycemic Control during Pregnancy—A Predictor of Vitamin C Status at Labor in Type 1 Diabetic Women? |
| title_full_unstemmed | Glycemic Control during Pregnancy—A Predictor of Vitamin C Status at Labor in Type 1 Diabetic Women? |
| title_short | Glycemic Control during Pregnancy—A Predictor of Vitamin C Status at Labor in Type 1 Diabetic Women? |
| title_sort | glycemic control during pregnancy a predictor of vitamin c status at labor in type 1 diabetic women |
| topic | type 1 diabetes mellitus HbA1c pregnancy vitamin C cohort study |
| url | https://www.mdpi.com/2076-3921/8/6/153 |
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