Botulinum Toxin Effects on Sensorimotor Integration in Focal Dystonias
(1) Background: In dystonia, the somatosensory temporal discrimination threshold (STDT) is abnormally increased at rest and higher and longer-lasting during movement execution in comparison with healthy subjects (HS), suggesting an abnormal sensorimotor integration. These abnormalities are thought t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/12/5/277 |
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| author | Maria Ilenia De Bartolo Nicoletta Manzo Gina Ferrazzano Viola Baione Daniele Belvisi Giovanni Fabbrini Alfredo Berardelli Antonella Conte |
| author_facet | Maria Ilenia De Bartolo Nicoletta Manzo Gina Ferrazzano Viola Baione Daniele Belvisi Giovanni Fabbrini Alfredo Berardelli Antonella Conte |
| author_sort | Maria Ilenia De Bartolo |
| collection | DOAJ |
| description | (1) Background: In dystonia, the somatosensory temporal discrimination threshold (STDT) is abnormally increased at rest and higher and longer-lasting during movement execution in comparison with healthy subjects (HS), suggesting an abnormal sensorimotor integration. These abnormalities are thought to depend on abnormal proprioceptive input coming from dystonic muscles. Since Botulinum toxin-A (BT-A) reduces proprioceptive input in the injected muscles, our study investigated the effects of BT-A on STDT tested at rest and during voluntary movement execution in patients with focal dystonia. (2) Methods: We enrolled 35 patients with focal dystonia: 14 patients with cervical dystonia (CD), 11 patients with blepharospasm (BSP), and 10 patients with focal hand dystonia (FHD); and 12 age-matched HS. STDT tested by delivering paired stimuli was measured in all subjects at rest and during index finger abductions. (3) Results: Patients with dystonia had higher STDT values at rest and during movement execution than HS. While BT-A did not modify STDT at rest, it reduced the abnormal values of STDT during movement in CD and FHD patients, but not in BSP patients. (4) Conclusions: BT-A improved abnormal sensorimotor integration in CD and FHD, most likely by decreasing the overflow of proprioceptive signaling from muscle dystonic activity to the thalamus. |
| first_indexed | 2024-03-10T20:14:14Z |
| format | Article |
| id | doaj.art-30681168098042adb0d4a816e6a87b8a |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T20:14:14Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-30681168098042adb0d4a816e6a87b8a2023-11-19T22:41:57ZengMDPI AGToxins2072-66512020-04-0112527710.3390/toxins12050277Botulinum Toxin Effects on Sensorimotor Integration in Focal DystoniasMaria Ilenia De Bartolo0Nicoletta Manzo1Gina Ferrazzano2Viola Baione3Daniele Belvisi4Giovanni Fabbrini5Alfredo Berardelli6Antonella Conte7IRCCS NEUROMED, Via Atinense, 18, 86077 Pozzilli (IS), ItalyIRCCS NEUROMED, Via Atinense, 18, 86077 Pozzilli (IS), ItalyDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, ItalyIRCCS NEUROMED, Via Atinense, 18, 86077 Pozzilli (IS), ItalyIRCCS NEUROMED, Via Atinense, 18, 86077 Pozzilli (IS), ItalyIRCCS NEUROMED, Via Atinense, 18, 86077 Pozzilli (IS), ItalyIRCCS NEUROMED, Via Atinense, 18, 86077 Pozzilli (IS), Italy(1) Background: In dystonia, the somatosensory temporal discrimination threshold (STDT) is abnormally increased at rest and higher and longer-lasting during movement execution in comparison with healthy subjects (HS), suggesting an abnormal sensorimotor integration. These abnormalities are thought to depend on abnormal proprioceptive input coming from dystonic muscles. Since Botulinum toxin-A (BT-A) reduces proprioceptive input in the injected muscles, our study investigated the effects of BT-A on STDT tested at rest and during voluntary movement execution in patients with focal dystonia. (2) Methods: We enrolled 35 patients with focal dystonia: 14 patients with cervical dystonia (CD), 11 patients with blepharospasm (BSP), and 10 patients with focal hand dystonia (FHD); and 12 age-matched HS. STDT tested by delivering paired stimuli was measured in all subjects at rest and during index finger abductions. (3) Results: Patients with dystonia had higher STDT values at rest and during movement execution than HS. While BT-A did not modify STDT at rest, it reduced the abnormal values of STDT during movement in CD and FHD patients, but not in BSP patients. (4) Conclusions: BT-A improved abnormal sensorimotor integration in CD and FHD, most likely by decreasing the overflow of proprioceptive signaling from muscle dystonic activity to the thalamus.https://www.mdpi.com/2072-6651/12/5/277sensorimotor integrationsomatosensory temporal discrimination thresholdfocal dystoniabotulinum toxin Acervical dystoniafocal hand dystonia |
| spellingShingle | Maria Ilenia De Bartolo Nicoletta Manzo Gina Ferrazzano Viola Baione Daniele Belvisi Giovanni Fabbrini Alfredo Berardelli Antonella Conte Botulinum Toxin Effects on Sensorimotor Integration in Focal Dystonias Toxins sensorimotor integration somatosensory temporal discrimination threshold focal dystonia botulinum toxin A cervical dystonia focal hand dystonia |
| title | Botulinum Toxin Effects on Sensorimotor Integration in Focal Dystonias |
| title_full | Botulinum Toxin Effects on Sensorimotor Integration in Focal Dystonias |
| title_fullStr | Botulinum Toxin Effects on Sensorimotor Integration in Focal Dystonias |
| title_full_unstemmed | Botulinum Toxin Effects on Sensorimotor Integration in Focal Dystonias |
| title_short | Botulinum Toxin Effects on Sensorimotor Integration in Focal Dystonias |
| title_sort | botulinum toxin effects on sensorimotor integration in focal dystonias |
| topic | sensorimotor integration somatosensory temporal discrimination threshold focal dystonia botulinum toxin A cervical dystonia focal hand dystonia |
| url | https://www.mdpi.com/2072-6651/12/5/277 |
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