Cannabinoid Signaling in Kidney Disease
Endocannabinoid signaling plays crucial roles in human physiology in the function of multiple systems. The two cannabinoid receptors, CB1 and CB2, are cell membrane proteins that interact with both exogenous and endogenous bioactive lipid ligands, or endocannabinoids. Recent evidence has established...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/12/10/1419 |
| _version_ | 1797600626016780288 |
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| author | Liana Arceri Thanh Khoa Nguyen Shannon Gibson Sophia Baker Rebecca A. Wingert |
| author_facet | Liana Arceri Thanh Khoa Nguyen Shannon Gibson Sophia Baker Rebecca A. Wingert |
| author_sort | Liana Arceri |
| collection | DOAJ |
| description | Endocannabinoid signaling plays crucial roles in human physiology in the function of multiple systems. The two cannabinoid receptors, CB1 and CB2, are cell membrane proteins that interact with both exogenous and endogenous bioactive lipid ligands, or endocannabinoids. Recent evidence has established that endocannabinoid signaling operates within the human kidney, as well as suggests the important role it plays in multiple renal pathologies. CB1, specifically, has been identified as the more prominent ECS receptor within the kidney, allowing us to place emphasis on this receptor. The activity of CB1 has been repeatedly shown to contribute to both diabetic and non-diabetic chronic kidney disease (CKD). Interestingly, recent reports of acute kidney injury (AKI) have been attributed to synthetic cannabinoid use. Therefore, the exploration of the ECS, its receptors, and its ligands can help provide better insight into new methods of treatment for a range of renal diseases. This review explores the endocannabinoid system, with a focus on its impacts within the healthy and diseased kidney. |
| first_indexed | 2024-03-11T03:50:30Z |
| format | Article |
| id | doaj.art-306a04701b0542fc92877466c09db362 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T03:50:30Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-306a04701b0542fc92877466c09db3622023-11-18T00:53:21ZengMDPI AGCells2073-44092023-05-011210141910.3390/cells12101419Cannabinoid Signaling in Kidney DiseaseLiana Arceri0Thanh Khoa Nguyen1Shannon Gibson2Sophia Baker3Rebecca A. Wingert4Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, IN 46556, USADepartment of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, IN 46556, USADepartment of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, IN 46556, USADepartment of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, IN 46556, USADepartment of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, IN 46556, USAEndocannabinoid signaling plays crucial roles in human physiology in the function of multiple systems. The two cannabinoid receptors, CB1 and CB2, are cell membrane proteins that interact with both exogenous and endogenous bioactive lipid ligands, or endocannabinoids. Recent evidence has established that endocannabinoid signaling operates within the human kidney, as well as suggests the important role it plays in multiple renal pathologies. CB1, specifically, has been identified as the more prominent ECS receptor within the kidney, allowing us to place emphasis on this receptor. The activity of CB1 has been repeatedly shown to contribute to both diabetic and non-diabetic chronic kidney disease (CKD). Interestingly, recent reports of acute kidney injury (AKI) have been attributed to synthetic cannabinoid use. Therefore, the exploration of the ECS, its receptors, and its ligands can help provide better insight into new methods of treatment for a range of renal diseases. This review explores the endocannabinoid system, with a focus on its impacts within the healthy and diseased kidney.https://www.mdpi.com/2073-4409/12/10/1419kidneynephroncannabinoid receptor 1podocytechronic kidney diseasefibrosis |
| spellingShingle | Liana Arceri Thanh Khoa Nguyen Shannon Gibson Sophia Baker Rebecca A. Wingert Cannabinoid Signaling in Kidney Disease Cells kidney nephron cannabinoid receptor 1 podocyte chronic kidney disease fibrosis |
| title | Cannabinoid Signaling in Kidney Disease |
| title_full | Cannabinoid Signaling in Kidney Disease |
| title_fullStr | Cannabinoid Signaling in Kidney Disease |
| title_full_unstemmed | Cannabinoid Signaling in Kidney Disease |
| title_short | Cannabinoid Signaling in Kidney Disease |
| title_sort | cannabinoid signaling in kidney disease |
| topic | kidney nephron cannabinoid receptor 1 podocyte chronic kidney disease fibrosis |
| url | https://www.mdpi.com/2073-4409/12/10/1419 |
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