Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma
Abstract Background The prognostic value of Hepatocyte growth factor (HGF) in non-clear cell renal cell carcinoma (RCC) is still unclear. The aim of this study is to evaluate the prognostic impact of HGF expression in a large cohort of chromophobe RCC (chRCC). Methods Patients who underwent renal su...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-023-01263-0 |
| _version_ | 1797827319488839680 |
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| author | Maximilian Erlmeier Marie Mikuteit Stefanie Zschäbitz Michael Autenrieth Wilko Weichert Arndt Hartmann Sandra Steffens Franziska Erlmeier |
| author_facet | Maximilian Erlmeier Marie Mikuteit Stefanie Zschäbitz Michael Autenrieth Wilko Weichert Arndt Hartmann Sandra Steffens Franziska Erlmeier |
| author_sort | Maximilian Erlmeier |
| collection | DOAJ |
| description | Abstract Background The prognostic value of Hepatocyte growth factor (HGF) in non-clear cell renal cell carcinoma (RCC) is still unclear. The aim of this study is to evaluate the prognostic impact of HGF expression in a large cohort of chromophobe RCC (chRCC). Methods Patients who underwent renal surgery due to chRCC were recruited. Clinical data was retrospectively evaluated. Tumor specimen were analyzed for HGF expression by immunohistochemistry. Results 81 chRCC patients were eligible for analysis, thereof 37 (45.7%) patients were positive for HGF. No significant associations were found for HGF expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in 5-year overall survival (OS) for patients with HGF− compared to HGF+ tumors (95.0% versus 90.9%; p = 0.410). Conclusions In chRCC HGF expression is not associated with parameters of aggressiveness or survival. |
| first_indexed | 2024-04-09T12:45:58Z |
| format | Article |
| id | doaj.art-306b2fb9b3df4d509ccb2bcb9a804d73 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-04-09T12:45:58Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-306b2fb9b3df4d509ccb2bcb9a804d732023-05-14T11:29:04ZengBMCBMC Urology1471-24902023-05-012311610.1186/s12894-023-01263-0Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinomaMaximilian Erlmeier0Marie Mikuteit1Stefanie Zschäbitz2Michael Autenrieth3Wilko Weichert4Arndt Hartmann5Sandra Steffens6Franziska Erlmeier7Department of Urology, München Klinik BogenhausenDepartment for Rheumatology and Immunology, Hannover Medical SchoolDept. of Medical Oncology, National Center of Tumor Diseases, University Hospital HeidelbergDepartment of Urology, Technical University of Munich, Klinikum Rechts der IsarInstitute for Pathology and Pathological Anatomy, Technical University MunichInstitute of Pathology, University Hospital of ErlangenDepartment for Rheumatology and Immunology, Hannover Medical SchoolInstitute of Pathology, University Hospital of ErlangenAbstract Background The prognostic value of Hepatocyte growth factor (HGF) in non-clear cell renal cell carcinoma (RCC) is still unclear. The aim of this study is to evaluate the prognostic impact of HGF expression in a large cohort of chromophobe RCC (chRCC). Methods Patients who underwent renal surgery due to chRCC were recruited. Clinical data was retrospectively evaluated. Tumor specimen were analyzed for HGF expression by immunohistochemistry. Results 81 chRCC patients were eligible for analysis, thereof 37 (45.7%) patients were positive for HGF. No significant associations were found for HGF expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in 5-year overall survival (OS) for patients with HGF− compared to HGF+ tumors (95.0% versus 90.9%; p = 0.410). Conclusions In chRCC HGF expression is not associated with parameters of aggressiveness or survival.https://doi.org/10.1186/s12894-023-01263-0Renal Cell CarcinomaHGFChromophobe histologySurvival |
| spellingShingle | Maximilian Erlmeier Marie Mikuteit Stefanie Zschäbitz Michael Autenrieth Wilko Weichert Arndt Hartmann Sandra Steffens Franziska Erlmeier Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma BMC Urology Renal Cell Carcinoma HGF Chromophobe histology Survival |
| title | Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma |
| title_full | Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma |
| title_fullStr | Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma |
| title_full_unstemmed | Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma |
| title_short | Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma |
| title_sort | immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma |
| topic | Renal Cell Carcinoma HGF Chromophobe histology Survival |
| url | https://doi.org/10.1186/s12894-023-01263-0 |
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