Postoperative analgesia for pediatric craniotomy patients: a randomized controlled trial
Abstract Background Pain is often observed in pediatric patients after craniotomy procedures, which could lead to some serious postoperative complications. However, the optimal formula for postoperative analgesia for pediatric neurosurgery has not been well established. This study aimed to explore t...
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | BMC Anesthesiology |
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| Online Access: | http://link.springer.com/article/10.1186/s12871-019-0722-x |
| _version_ | 1818340691141459968 |
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| author | Fei Xing Li Xin An Fu Shan Xue Chun Mei Zhao Ya Fan Bai |
| author_facet | Fei Xing Li Xin An Fu Shan Xue Chun Mei Zhao Ya Fan Bai |
| author_sort | Fei Xing |
| collection | DOAJ |
| description | Abstract Background Pain is often observed in pediatric patients after craniotomy procedures, which could lead to some serious postoperative complications. However, the optimal formula for postoperative analgesia for pediatric neurosurgery has not been well established. This study aimed to explore the optimal options and formulas for postoperative analgesia in pediatric neurosurgery. Methods Three hundred and twenty patients aged 1 to 12-years old who underwent craniotomy were randomly assigned to receive 4 different regimens of patient-controlled analgesia. The formulas used were as follows: Control group included normal saline 100 ml, with a background infusion of 2 ml/h, bolus 0.5 ml; Fentanyl group was used with a background infusion of 0.1–0.2 μg/k·h, bolus 0.1–0.2 μg/kg; Morphine group was used with a background infusion of 10–20 μg/kg·h, bolus 10–20 μg/kg; while Tramadol group was used with a background infusion of 100–400 μg/kg·h, bolus 100–200 μg/kg. Postoperative pain scores and analgesia-related complication were recorded respectively. Comparative analysis was performed between the four groups. Results In comparison of all groups with each other, lower pain scores were shown at 1 h and 8 h after surgery in Morphine group versus Tramadol, Fentanyl and Control groups (P < 0.05). Both Tramadol and Fentanyl groups showed lower pain scores in comparison to Control group (P < 0.05). Nausea and vomiting were observed more in Tramadol group in comparison to all other groups during the 48 h of PCIA usage after operation (P = 0.020). Much more rescue medicines including ibuprofen and morphine were used in Control group (CI = 0.000–0.019). Changes in consciousness and respiratory depression were not observed in study groups. Moderate-to-severe pain was observed in a total of 56 (17.5%) of the study population. Multiple regression analysis for identifying risk factors for moderate-to-severe pain revealed that, younger children (OR = 1.161, 1.027–1.312, P = 0.017), occipital craniotomy (OR = 0.374, 0.155–0.905, P = 0.029), and morphine treatment (OR = 0.077, 0.021–0.281, P < 0.001) are the relevant factors. Conclusions Compared with other analgesic projects, PCIA or NCIA analgesia with morphine appears to be the safest and most effective postoperative analgesia program for pediatric patients who underwent neurosurgical operations. Trial registration Chinese Clinical Trial Registry. No: ChiCTR-IOC-15007676. Prospective registration. http://www.chictr.org.cn/index.aspx. |
| first_indexed | 2024-12-13T15:46:55Z |
| format | Article |
| id | doaj.art-306bb86443ec4a34b8bdef73bc134575 |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-12-13T15:46:55Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-306bb86443ec4a34b8bdef73bc1345752022-12-21T23:39:41ZengBMCBMC Anesthesiology1471-22532019-04-0119111010.1186/s12871-019-0722-xPostoperative analgesia for pediatric craniotomy patients: a randomized controlled trialFei Xing0Li Xin An1Fu Shan Xue2Chun Mei Zhao3Ya Fan Bai4Department of Anesthesia, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Anesthesia, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Anesthesia, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Anesthesia, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Anesthesia, Beijing Friendship Hospital, Capital Medical UniversityAbstract Background Pain is often observed in pediatric patients after craniotomy procedures, which could lead to some serious postoperative complications. However, the optimal formula for postoperative analgesia for pediatric neurosurgery has not been well established. This study aimed to explore the optimal options and formulas for postoperative analgesia in pediatric neurosurgery. Methods Three hundred and twenty patients aged 1 to 12-years old who underwent craniotomy were randomly assigned to receive 4 different regimens of patient-controlled analgesia. The formulas used were as follows: Control group included normal saline 100 ml, with a background infusion of 2 ml/h, bolus 0.5 ml; Fentanyl group was used with a background infusion of 0.1–0.2 μg/k·h, bolus 0.1–0.2 μg/kg; Morphine group was used with a background infusion of 10–20 μg/kg·h, bolus 10–20 μg/kg; while Tramadol group was used with a background infusion of 100–400 μg/kg·h, bolus 100–200 μg/kg. Postoperative pain scores and analgesia-related complication were recorded respectively. Comparative analysis was performed between the four groups. Results In comparison of all groups with each other, lower pain scores were shown at 1 h and 8 h after surgery in Morphine group versus Tramadol, Fentanyl and Control groups (P < 0.05). Both Tramadol and Fentanyl groups showed lower pain scores in comparison to Control group (P < 0.05). Nausea and vomiting were observed more in Tramadol group in comparison to all other groups during the 48 h of PCIA usage after operation (P = 0.020). Much more rescue medicines including ibuprofen and morphine were used in Control group (CI = 0.000–0.019). Changes in consciousness and respiratory depression were not observed in study groups. Moderate-to-severe pain was observed in a total of 56 (17.5%) of the study population. Multiple regression analysis for identifying risk factors for moderate-to-severe pain revealed that, younger children (OR = 1.161, 1.027–1.312, P = 0.017), occipital craniotomy (OR = 0.374, 0.155–0.905, P = 0.029), and morphine treatment (OR = 0.077, 0.021–0.281, P < 0.001) are the relevant factors. Conclusions Compared with other analgesic projects, PCIA or NCIA analgesia with morphine appears to be the safest and most effective postoperative analgesia program for pediatric patients who underwent neurosurgical operations. Trial registration Chinese Clinical Trial Registry. No: ChiCTR-IOC-15007676. Prospective registration. http://www.chictr.org.cn/index.aspx.http://link.springer.com/article/10.1186/s12871-019-0722-xPainPostoperativeChildCraniotomy |
| spellingShingle | Fei Xing Li Xin An Fu Shan Xue Chun Mei Zhao Ya Fan Bai Postoperative analgesia for pediatric craniotomy patients: a randomized controlled trial BMC Anesthesiology Pain Postoperative Child Craniotomy |
| title | Postoperative analgesia for pediatric craniotomy patients: a randomized controlled trial |
| title_full | Postoperative analgesia for pediatric craniotomy patients: a randomized controlled trial |
| title_fullStr | Postoperative analgesia for pediatric craniotomy patients: a randomized controlled trial |
| title_full_unstemmed | Postoperative analgesia for pediatric craniotomy patients: a randomized controlled trial |
| title_short | Postoperative analgesia for pediatric craniotomy patients: a randomized controlled trial |
| title_sort | postoperative analgesia for pediatric craniotomy patients a randomized controlled trial |
| topic | Pain Postoperative Child Craniotomy |
| url | http://link.springer.com/article/10.1186/s12871-019-0722-x |
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