Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices
Previous studies have revealed associations between heavy metals and extensive health problems. However, the association between heavy metals and metabolic problems remains poorly defined. This study aims to investigate relationships between heavy metals and metabolic syndrome (MetS), lipid accumula...
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MDPI AG
2020-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/9/2666 |
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| author | Wei-Lun Wen Chih-Wen Wang Da-Wei Wu Szu-Chia Chen Chih-Hsing Hung Chao-Hung Kuo |
| author_facet | Wei-Lun Wen Chih-Wen Wang Da-Wei Wu Szu-Chia Chen Chih-Hsing Hung Chao-Hung Kuo |
| author_sort | Wei-Lun Wen |
| collection | DOAJ |
| description | Previous studies have revealed associations between heavy metals and extensive health problems. However, the association between heavy metals and metabolic problems remains poorly defined. This study aims to investigate relationships between heavy metals and metabolic syndrome (MetS), lipid accumulation product (LAP), visceral adiposity index (VAI), and anthropometric indices, including body roundness index (BRI), conicity index (CI), body adiposity index (BAI), and abdominal volume index (AVI). We conducted a health survey of people living in southern Taiwan. Six heavy metals were measured: lead (Pb) in blood and nickel (Ni), chromium (Cr), manganese (Mn), arsenic (As), and copper (Cu) in urine. A total of 2444 participants (976 men and 1468 women) were enrolled. MetS was defined according to the Adult Treatment Panel III for Asians. Multivariable analysis showed that participants with high urine Ni (log per 1 μg/L; odds ratio (OR): 1.193; 95% confidence interval (CI): 1.019 to 1.397; <i>p</i> = 0.028) and high urine Cu (log per 1 μg/dL; OR: 3.317; 95% CI: 2.254 to 4.883; <i>p</i> < 0.001) concentrations were significantly associated with MetS. There was a significant trend of a stepwise increase in blood Pb and urine Ni, As, and Cu according to the number of MetS components (from 0 to 5, a linear <i>p</i> ≤ 0.002 for trend). For the determinants of indices, urine Cu was positively correlated with LAP, BRI, CI, and VAI; blood Pb was positively correlated with BRI, BAI, and AVI; urine Ni was positively correlated with LAP. High urine Cu and urine Ni levels were significantly associated with MetS, and there was a significant trend for stepwise increases in blood Pb and urine Ni, As, and Cu, accompanied by an increasing number of MetS components. Furthermore, several indices were positively correlated with urine Cu, urine Ni, and blood Pb. |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-10T16:38:32Z |
| publishDate | 2020-09-01 |
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| series | Nutrients |
| spelling | doaj.art-306dff1813a14d21918860be04aba70e2023-11-20T12:10:05ZengMDPI AGNutrients2072-66432020-09-01129266610.3390/nu12092666Associations of Heavy Metals with Metabolic Syndrome and Anthropometric IndicesWei-Lun Wen0Chih-Wen Wang1Da-Wei Wu2Szu-Chia Chen3Chih-Hsing Hung4Chao-Hung Kuo5Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanResearch Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanPrevious studies have revealed associations between heavy metals and extensive health problems. However, the association between heavy metals and metabolic problems remains poorly defined. This study aims to investigate relationships between heavy metals and metabolic syndrome (MetS), lipid accumulation product (LAP), visceral adiposity index (VAI), and anthropometric indices, including body roundness index (BRI), conicity index (CI), body adiposity index (BAI), and abdominal volume index (AVI). We conducted a health survey of people living in southern Taiwan. Six heavy metals were measured: lead (Pb) in blood and nickel (Ni), chromium (Cr), manganese (Mn), arsenic (As), and copper (Cu) in urine. A total of 2444 participants (976 men and 1468 women) were enrolled. MetS was defined according to the Adult Treatment Panel III for Asians. Multivariable analysis showed that participants with high urine Ni (log per 1 μg/L; odds ratio (OR): 1.193; 95% confidence interval (CI): 1.019 to 1.397; <i>p</i> = 0.028) and high urine Cu (log per 1 μg/dL; OR: 3.317; 95% CI: 2.254 to 4.883; <i>p</i> < 0.001) concentrations were significantly associated with MetS. There was a significant trend of a stepwise increase in blood Pb and urine Ni, As, and Cu according to the number of MetS components (from 0 to 5, a linear <i>p</i> ≤ 0.002 for trend). For the determinants of indices, urine Cu was positively correlated with LAP, BRI, CI, and VAI; blood Pb was positively correlated with BRI, BAI, and AVI; urine Ni was positively correlated with LAP. High urine Cu and urine Ni levels were significantly associated with MetS, and there was a significant trend for stepwise increases in blood Pb and urine Ni, As, and Cu, accompanied by an increasing number of MetS components. Furthermore, several indices were positively correlated with urine Cu, urine Ni, and blood Pb.https://www.mdpi.com/2072-6643/12/9/2666heavy metalsmetabolic syndromeanthropometric indices |
| spellingShingle | Wei-Lun Wen Chih-Wen Wang Da-Wei Wu Szu-Chia Chen Chih-Hsing Hung Chao-Hung Kuo Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices Nutrients heavy metals metabolic syndrome anthropometric indices |
| title | Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices |
| title_full | Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices |
| title_fullStr | Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices |
| title_full_unstemmed | Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices |
| title_short | Associations of Heavy Metals with Metabolic Syndrome and Anthropometric Indices |
| title_sort | associations of heavy metals with metabolic syndrome and anthropometric indices |
| topic | heavy metals metabolic syndrome anthropometric indices |
| url | https://www.mdpi.com/2072-6643/12/9/2666 |
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