Clove Extract and Grape Seed Oil Nanoemulsion for Oral Diseases Therapy: Antibacterial and Antioxidant Activities
The growth of micro-organisms that acquire resistance to most commercially available antibiotics is occurring rapidly. Consequently, a pressing necessity exists to identify and detect new antimicrobial substances. This study aimed to analyze the antioxidant and antibacterial activity of nanoemulsion...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Universitas Islam Bandung
2023-12-01
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| Series: | Global Medical & Health Communication |
| Subjects: | |
| Online Access: | https://ejournal.unisba.ac.id/index.php/gmhc/article/view/12916 |
| _version_ | 1797352409654099968 |
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| author | Julia Hartati Meta Maulida Damayanti Ismet Muchtar Nur Annisa Rahmah Furqaani Ajeng Kartika Sari Meike Rachmawati Tita Barriah Siddiq Taufik Muhammad Fakih Faqih Radina |
| author_facet | Julia Hartati Meta Maulida Damayanti Ismet Muchtar Nur Annisa Rahmah Furqaani Ajeng Kartika Sari Meike Rachmawati Tita Barriah Siddiq Taufik Muhammad Fakih Faqih Radina |
| author_sort | Julia Hartati |
| collection | DOAJ |
| description | The growth of micro-organisms that acquire resistance to most commercially available antibiotics is occurring rapidly. Consequently, a pressing necessity exists to identify and detect new antimicrobial substances. This study aimed to analyze the antioxidant and antibacterial activity of nanoemulsion clove extract and grape seed oil. This research was conducted in June 2023 using experimental methods at the Research Laboratory of the Universitas Islam Bandung Pharmaceutical Study Program by developing a nanoemulsion preparation containing clove extract (Syzygium aromaticum L.) and grape seed oil (Vitis vinifera L.). Antioxidant activity was tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Antibacterial activity was tested using the agar diffusion method by measuring the growth inhibitory diameter of Staphylococcus aureus and Streptococcus mutans bacteria and divided into four groups formulas based on the addition of clove extract with different concentrations in the nanoemulsion base (FA=0.25%, FB=0.5%, FC=0.75%, and FD=1%) to see the best results. The result shows nanoemulsion preparations have antioxidant properties in the DPPH test. The FA formula has the highest IC50, namely 1,117.56 ppm. The antibacterial activity of Staphylococcus aureus and Streptococcus mutans has an inhibition zone, although it is still in the category of inhibiting bacterial growth, but does not kill growth. The nanoemulsion formulation, comprising clove extract and grape seed oil, has exhibited exceptional antioxidant properties and substantial antimicrobial efficacy against prevalent oral bacterial strains. |
| first_indexed | 2024-03-08T13:16:07Z |
| format | Article |
| id | doaj.art-3070425b3f004fc6af3d63788f619873 |
| institution | Directory Open Access Journal |
| issn | 2301-9123 2460-5441 |
| language | English |
| last_indexed | 2024-03-08T13:16:07Z |
| publishDate | 2023-12-01 |
| publisher | Universitas Islam Bandung |
| record_format | Article |
| series | Global Medical & Health Communication |
| spelling | doaj.art-3070425b3f004fc6af3d63788f6198732024-01-18T06:47:39ZengUniversitas Islam BandungGlobal Medical & Health Communication2301-91232460-54412023-12-0111310.29313/gmhc.v11i3.129164963Clove Extract and Grape Seed Oil Nanoemulsion for Oral Diseases Therapy: Antibacterial and Antioxidant ActivitiesJulia Hartati0Meta Maulida Damayanti1Ismet Muchtar Nur2Annisa Rahmah Furqaani3Ajeng Kartika Sari4Meike Rachmawati5Tita Barriah Siddiq6Taufik Muhammad Fakih7Faqih Radina8Department of Microbiology, Faculty of Medicine, Universitas Islam Bandung, BandungDepartment of Pathology Anatomy, Faculty of Medicine, Universitas Islam Bandung, BandungDepartment of Pathology Anatomy, Faculty of Medicine, Universitas Islam Bandung, BandungDepartment of Biology Medic, Faculty of Medicine, Universitas Islam Bandung, BandungDepartment of Biology Medic, Faculty of Medicine, Universitas Islam Bandung, BandungDepartment of Pathology Anatomy, Faculty of Medicine, Universitas Islam Bandung, BandungDepartment of Medical Education, Bioethics, and Humanity, Faculty of Medicine, Universitas Islam Bandung, BandungDepartment of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung, BandungDepartment of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam BandungThe growth of micro-organisms that acquire resistance to most commercially available antibiotics is occurring rapidly. Consequently, a pressing necessity exists to identify and detect new antimicrobial substances. This study aimed to analyze the antioxidant and antibacterial activity of nanoemulsion clove extract and grape seed oil. This research was conducted in June 2023 using experimental methods at the Research Laboratory of the Universitas Islam Bandung Pharmaceutical Study Program by developing a nanoemulsion preparation containing clove extract (Syzygium aromaticum L.) and grape seed oil (Vitis vinifera L.). Antioxidant activity was tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Antibacterial activity was tested using the agar diffusion method by measuring the growth inhibitory diameter of Staphylococcus aureus and Streptococcus mutans bacteria and divided into four groups formulas based on the addition of clove extract with different concentrations in the nanoemulsion base (FA=0.25%, FB=0.5%, FC=0.75%, and FD=1%) to see the best results. The result shows nanoemulsion preparations have antioxidant properties in the DPPH test. The FA formula has the highest IC50, namely 1,117.56 ppm. The antibacterial activity of Staphylococcus aureus and Streptococcus mutans has an inhibition zone, although it is still in the category of inhibiting bacterial growth, but does not kill growth. The nanoemulsion formulation, comprising clove extract and grape seed oil, has exhibited exceptional antioxidant properties and substantial antimicrobial efficacy against prevalent oral bacterial strains.https://ejournal.unisba.ac.id/index.php/gmhc/article/view/12916antibacterialantioxidantclove extractgrape seed oilnanoemulsion |
| spellingShingle | Julia Hartati Meta Maulida Damayanti Ismet Muchtar Nur Annisa Rahmah Furqaani Ajeng Kartika Sari Meike Rachmawati Tita Barriah Siddiq Taufik Muhammad Fakih Faqih Radina Clove Extract and Grape Seed Oil Nanoemulsion for Oral Diseases Therapy: Antibacterial and Antioxidant Activities Global Medical & Health Communication antibacterial antioxidant clove extract grape seed oil nanoemulsion |
| title | Clove Extract and Grape Seed Oil Nanoemulsion for Oral Diseases Therapy: Antibacterial and Antioxidant Activities |
| title_full | Clove Extract and Grape Seed Oil Nanoemulsion for Oral Diseases Therapy: Antibacterial and Antioxidant Activities |
| title_fullStr | Clove Extract and Grape Seed Oil Nanoemulsion for Oral Diseases Therapy: Antibacterial and Antioxidant Activities |
| title_full_unstemmed | Clove Extract and Grape Seed Oil Nanoemulsion for Oral Diseases Therapy: Antibacterial and Antioxidant Activities |
| title_short | Clove Extract and Grape Seed Oil Nanoemulsion for Oral Diseases Therapy: Antibacterial and Antioxidant Activities |
| title_sort | clove extract and grape seed oil nanoemulsion for oral diseases therapy antibacterial and antioxidant activities |
| topic | antibacterial antioxidant clove extract grape seed oil nanoemulsion |
| url | https://ejournal.unisba.ac.id/index.php/gmhc/article/view/12916 |
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