Neuroprotective Capability of Narcissoside in 6-OHDA-Exposed Parkinson’s Disease Models through Enhancing the MiR200a/Nrf-2/GSH Axis and Mediating MAPK/Akt Associated Signaling Pathway

Neuroprotective Capability of Narcissoside in 6-OHDA-Exposed Parkinson’s Disease Models through Enhancing the MiR200a/Nrf-2/GSH Axis and Mediating MAPK/Akt Associated Signaling Pathway

We assessed the antioxidant potential of narcissoside from <i>Sambucus nigra</i> flowers (elderflowers) in Parkinson’s disease models in vitro and in vivo. The results showed that narcissoside lessened the 6-hydroxydopamine (6-OHDA)-induced increase in reactive oxygen species (ROS) and a...

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Main Authors: Ru-Huei Fu, Chia-Wen Tsai, Shih-Ping Liu, Shao-Chih Chiu, Yen-Chuan Chen, Yu-Ting Chiang, Yun-Hua Kuo, Woei-Cherng Shyu, Shinn-Zong Lin
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antioxidants
Subjects:
Parkinson disease
narcissoside
6-hydroxydopamine
SH-SY5Y
<i>C. elegans</i>
apoptosis
Online Access:https://www.mdpi.com/2076-3921/11/11/2089

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