Macrophage-Targeted Sodium Chlorite (NP001) Slows Progression of Amyotrophic Lateral Sclerosis (ALS) through Regulation of Microbial Translocation

Macrophage-Targeted Sodium Chlorite (NP001) Slows Progression of Amyotrophic Lateral Sclerosis (ALS) through Regulation of Microbial Translocation

Amyotrophic lateral sclerosis (ALS) is a heterogeneous, progressive, and universally fatal neurodegenerative disease. A subset of ALS patients has measurable plasma levels of lipopolysaccharide (LPS) and C-reactive protein (CRP) consistent with low-grade microbial translocation (MT). Unless interrup...

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Bibliographic Details
Main Authors: Rongzhen Zhang, Paige M. Bracci, Ari Azhir, Bruce D. Forrest, Michael S. McGrath
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomedicines
Subjects:
ALS
LPS
microbial translocation
biomarker
macrophage
neuroinflammation
Online Access:https://www.mdpi.com/2227-9059/10/11/2907

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