Microbiological and clinical characteristics of invasive Group B Streptococcal blood stream infections in children and adults from Qatar
Abstract Introduction Group B Streptococci (GBS) colonize almost one third of human gastrointestinal and genitourinary tracts, particularly in females. The aim of this study is to evaluate the epidemiology, microbiological characteristics, and clinical outcomes of invasive GBS disease in Qatar from...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07801-9 |
| _version_ | 1828119849309569024 |
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| author | Maisa Ali Mohammed A. Alamin Gawahir A. Ali Khalid Alzubaidi Bashir Ali Abdellatif Ismail Joanne Daghfal Muna Almaslamani Hamad Abdel Hadi |
| author_facet | Maisa Ali Mohammed A. Alamin Gawahir A. Ali Khalid Alzubaidi Bashir Ali Abdellatif Ismail Joanne Daghfal Muna Almaslamani Hamad Abdel Hadi |
| author_sort | Maisa Ali |
| collection | DOAJ |
| description | Abstract Introduction Group B Streptococci (GBS) colonize almost one third of human gastrointestinal and genitourinary tracts, particularly in females. The aim of this study is to evaluate the epidemiology, microbiological characteristics, and clinical outcomes of invasive GBS disease in Qatar from all age groups. Methods A retrospective study was conducted on patients with confirmed GBS blood stream infections during the period between January 2015 and March 2019. Microbiological identification was performed using automated BD PhoenixTM system, while additional antimicrobial susceptibility tests were performed using E test and disc diffusion methods. Result During the four years period, the incidence steadily rose from 1.48 to 2.09 cases per 100.000 population. Out of 196 confirmed cases of invasive GBS infections, the majority were females (63.7%, 125/196) of which 44.8% were pregnant and 53.6% were colonized. Three distinct affected age groups were identified: children ≤ 4 years of age (35.7%), young adults 25–34 (20.9%) and the elderly ≥ 65 year (17.4%). Presenting symptoms were mild with fever in 53% of cases while 89% of cases had Pitt bacteraemia score of ≤ 2. Isolates were universally sensitive to penicillin, ceftriaxone, and vancomycin at 100% but with significant resistance to erythromycin (49%) and clindamycin (28.6%) while 16.8% had inducible clindamycin resistance. Clinical outcomes showed cure rate of 87.25% with complications in (8.76%) and 4% mortality. Conclusion There is a rising trend of Group B Streptococcal blood stream infections in Qatar with significantly high clindamycin and erythromycin resistance rates. Universal susceptibility rates were demonstrated for penicillin, ceftriaxone, and vancomycin. |
| first_indexed | 2024-04-11T13:54:41Z |
| format | Article |
| id | doaj.art-30729784e05947c28b004add11113a2f |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-11T13:54:41Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-30729784e05947c28b004add11113a2f2022-12-22T04:20:22ZengBMCBMC Infectious Diseases1471-23342022-11-012211710.1186/s12879-022-07801-9Microbiological and clinical characteristics of invasive Group B Streptococcal blood stream infections in children and adults from QatarMaisa Ali0Mohammed A. Alamin1Gawahir A. Ali2Khalid Alzubaidi3Bashir Ali4Abdellatif Ismail5Joanne Daghfal6Muna Almaslamani7Hamad Abdel Hadi8Communicable Diseases Centre, Infectious Diseases Department, Hamad Medical CorporationInternal Medicine Department, Hamad Medical CorporationCommunicable Diseases Centre, Infectious Diseases Department, Hamad Medical CorporationPaediatric Infectious Diseases, Sidra MedicineInternal Medicine Department, Hamad Medical CorporationInternal Medicine Department, Hamad Medical CorporationCommunicable Diseases Centre, Infectious Diseases Department, Hamad Medical CorporationCommunicable Diseases Centre, Infectious Diseases Department, Hamad Medical CorporationCommunicable Diseases Centre, Infectious Diseases Department, Hamad Medical CorporationAbstract Introduction Group B Streptococci (GBS) colonize almost one third of human gastrointestinal and genitourinary tracts, particularly in females. The aim of this study is to evaluate the epidemiology, microbiological characteristics, and clinical outcomes of invasive GBS disease in Qatar from all age groups. Methods A retrospective study was conducted on patients with confirmed GBS blood stream infections during the period between January 2015 and March 2019. Microbiological identification was performed using automated BD PhoenixTM system, while additional antimicrobial susceptibility tests were performed using E test and disc diffusion methods. Result During the four years period, the incidence steadily rose from 1.48 to 2.09 cases per 100.000 population. Out of 196 confirmed cases of invasive GBS infections, the majority were females (63.7%, 125/196) of which 44.8% were pregnant and 53.6% were colonized. Three distinct affected age groups were identified: children ≤ 4 years of age (35.7%), young adults 25–34 (20.9%) and the elderly ≥ 65 year (17.4%). Presenting symptoms were mild with fever in 53% of cases while 89% of cases had Pitt bacteraemia score of ≤ 2. Isolates were universally sensitive to penicillin, ceftriaxone, and vancomycin at 100% but with significant resistance to erythromycin (49%) and clindamycin (28.6%) while 16.8% had inducible clindamycin resistance. Clinical outcomes showed cure rate of 87.25% with complications in (8.76%) and 4% mortality. Conclusion There is a rising trend of Group B Streptococcal blood stream infections in Qatar with significantly high clindamycin and erythromycin resistance rates. Universal susceptibility rates were demonstrated for penicillin, ceftriaxone, and vancomycin.https://doi.org/10.1186/s12879-022-07801-9Group B Streptococci (GBS)Strep agalactiaeSepsisBacteraemiaQatar |
| spellingShingle | Maisa Ali Mohammed A. Alamin Gawahir A. Ali Khalid Alzubaidi Bashir Ali Abdellatif Ismail Joanne Daghfal Muna Almaslamani Hamad Abdel Hadi Microbiological and clinical characteristics of invasive Group B Streptococcal blood stream infections in children and adults from Qatar BMC Infectious Diseases Group B Streptococci (GBS) Strep agalactiae Sepsis Bacteraemia Qatar |
| title | Microbiological and clinical characteristics of invasive Group B Streptococcal blood stream infections in children and adults from Qatar |
| title_full | Microbiological and clinical characteristics of invasive Group B Streptococcal blood stream infections in children and adults from Qatar |
| title_fullStr | Microbiological and clinical characteristics of invasive Group B Streptococcal blood stream infections in children and adults from Qatar |
| title_full_unstemmed | Microbiological and clinical characteristics of invasive Group B Streptococcal blood stream infections in children and adults from Qatar |
| title_short | Microbiological and clinical characteristics of invasive Group B Streptococcal blood stream infections in children and adults from Qatar |
| title_sort | microbiological and clinical characteristics of invasive group b streptococcal blood stream infections in children and adults from qatar |
| topic | Group B Streptococci (GBS) Strep agalactiae Sepsis Bacteraemia Qatar |
| url | https://doi.org/10.1186/s12879-022-07801-9 |
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