Lifting the veil on amyloid drug design
High resolution structures and computational methods have been used to identify compounds that prevent amyloid fibrils associated with Alzheimer’s disease from dissociating into toxic species.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2013-07-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/01089 |
| _version_ | 1811253414610337792 |
|---|---|
| author | Kathryn E Tiller Peter M Tessier |
| author_facet | Kathryn E Tiller Peter M Tessier |
| author_sort | Kathryn E Tiller |
| collection | DOAJ |
| description | High resolution structures and computational methods have been used to identify compounds that prevent amyloid fibrils associated with Alzheimer’s disease from dissociating into toxic species. |
| first_indexed | 2024-04-12T16:49:41Z |
| format | Article |
| id | doaj.art-3075342b742c4768889db211ae45a7ae |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:49:41Z |
| publishDate | 2013-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-3075342b742c4768889db211ae45a7ae2022-12-22T03:24:25ZengeLife Sciences Publications LtdeLife2050-084X2013-07-01210.7554/eLife.01089Lifting the veil on amyloid drug designKathryn E Tiller0Peter M Tessier1Center for Biotechnology & Interdisciplinary Studies, Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, New York, United StatesCenter for Biotechnology & Interdisciplinary Studies, Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, New York, United StatesHigh resolution structures and computational methods have been used to identify compounds that prevent amyloid fibrils associated with Alzheimer’s disease from dissociating into toxic species.https://elifesciences.org/articles/01089amyloid fibercomputational biologydrug discoveryAlzheimer's diseaseligand docking |
| spellingShingle | Kathryn E Tiller Peter M Tessier Lifting the veil on amyloid drug design eLife amyloid fiber computational biology drug discovery Alzheimer's disease ligand docking |
| title | Lifting the veil on amyloid drug design |
| title_full | Lifting the veil on amyloid drug design |
| title_fullStr | Lifting the veil on amyloid drug design |
| title_full_unstemmed | Lifting the veil on amyloid drug design |
| title_short | Lifting the veil on amyloid drug design |
| title_sort | lifting the veil on amyloid drug design |
| topic | amyloid fiber computational biology drug discovery Alzheimer's disease ligand docking |
| url | https://elifesciences.org/articles/01089 |
| work_keys_str_mv | AT kathrynetiller liftingtheveilonamyloiddrugdesign AT petermtessier liftingtheveilonamyloiddrugdesign |