The roles of connectivity and neuronal phenotype in determining the pattern of α-synuclein pathology in Parkinson's disease

The roles of connectivity and neuronal phenotype in determining the pattern of α-synuclein pathology in Parkinson's disease

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and motor dysfunction has been attributed to loss of dopaminergic neurons. However, motor dysfunction is only one of many symptoms experienced by patients. A neuropathological hallmark of PD is intraneuronal protei...

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Bibliographic Details
Main Authors: Michael X. Henderson, Martin T. Henrich, Fanni F. Geibl, Wolfgang H. Oertel, Patrik Brundin, D. James Surmeier
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Neurobiology of Disease
Subjects:
Vulnerability
Neurodegeneration
Lewy pathology
Synaptic
Propagation
SNCA
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612200078X

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