The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm
Prediction errors are thought to drive associative fear learning. Surprisingly little is known about the possible contribution of the cerebellum. To address this question, healthy participants underwent a differential fear conditioning paradigm during 7T magnetic resonance imaging. An event-related...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2019-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/46831 |
| _version_ | 1811181446463750144 |
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| author | Thomas Michael Ernst Anna Evelina Brol Marcel Gratz Christoph Ritter Ulrike Bingel Marc Schlamann Stefan Maderwald Harald H Quick Christian Josef Merz Dagmar Timmann |
| author_facet | Thomas Michael Ernst Anna Evelina Brol Marcel Gratz Christoph Ritter Ulrike Bingel Marc Schlamann Stefan Maderwald Harald H Quick Christian Josef Merz Dagmar Timmann |
| author_sort | Thomas Michael Ernst |
| collection | DOAJ |
| description | Prediction errors are thought to drive associative fear learning. Surprisingly little is known about the possible contribution of the cerebellum. To address this question, healthy participants underwent a differential fear conditioning paradigm during 7T magnetic resonance imaging. An event-related design allowed us to separate cerebellar fMRI signals related to the visual conditioned stimulus (CS) from signals related to the subsequent unconditioned stimulus (US; an aversive electric shock). We found significant activation of cerebellar lobules Crus I and VI bilaterally related to the CS+ compared to the CS-. Most importantly, significant activation of lobules Crus I and VI was also present during the unexpected omission of the US in unreinforced CS+ acquisition trials. This activation disappeared during extinction when US omission became expected. These findings provide evidence that the cerebellum has to be added to the neural network processing predictions and prediction errors in the emotional domain. |
| first_indexed | 2024-04-11T09:17:52Z |
| format | Article |
| id | doaj.art-30761d716c7145b3aa0e53a6a95f0c35 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:17:52Z |
| publishDate | 2019-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-30761d716c7145b3aa0e53a6a95f0c352022-12-22T04:32:17ZengeLife Sciences Publications LtdeLife2050-084X2019-08-01810.7554/eLife.46831The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigmThomas Michael Ernst0https://orcid.org/0000-0002-2170-9241Anna Evelina Brol1Marcel Gratz2Christoph Ritter3Ulrike Bingel4Marc Schlamann5Stefan Maderwald6Harald H Quick7Christian Josef Merz8Dagmar Timmann9Department of Neurology, Essen University Hospital, Essen, Germany; Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, GermanyDepartment of Neurology, Essen University Hospital, Essen, GermanyErwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany; High-Field and Hybrid MR Imaging, Essen University Hospital, Essen, GermanyDepartment of Neurology, Essen University Hospital, Essen, GermanyDepartment of Neurology, Essen University Hospital, Essen, GermanyInstitute of Diagnostic and Interventional Radiology and Neuroradiology, Essen University Hospital, Essen, Germany; Department of Neuroradiology, University Hospital Cologne, Cologne, GermanyErwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, GermanyErwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany; High-Field and Hybrid MR Imaging, Essen University Hospital, Essen, GermanyDepartment of Cognitive Psychology, Institute of Cognitive Neuroscience, Ruhr University Bochum, Bochum, GermanyDepartment of Neurology, Essen University Hospital, Essen, Germany; Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, GermanyPrediction errors are thought to drive associative fear learning. Surprisingly little is known about the possible contribution of the cerebellum. To address this question, healthy participants underwent a differential fear conditioning paradigm during 7T magnetic resonance imaging. An event-related design allowed us to separate cerebellar fMRI signals related to the visual conditioned stimulus (CS) from signals related to the subsequent unconditioned stimulus (US; an aversive electric shock). We found significant activation of cerebellar lobules Crus I and VI bilaterally related to the CS+ compared to the CS-. Most importantly, significant activation of lobules Crus I and VI was also present during the unexpected omission of the US in unreinforced CS+ acquisition trials. This activation disappeared during extinction when US omission became expected. These findings provide evidence that the cerebellum has to be added to the neural network processing predictions and prediction errors in the emotional domain.https://elifesciences.org/articles/46831emotionsextinctionfearvermiscerebellar hemisphereaversive conditioning |
| spellingShingle | Thomas Michael Ernst Anna Evelina Brol Marcel Gratz Christoph Ritter Ulrike Bingel Marc Schlamann Stefan Maderwald Harald H Quick Christian Josef Merz Dagmar Timmann The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm eLife emotions extinction fear vermis cerebellar hemisphere aversive conditioning |
| title | The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm |
| title_full | The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm |
| title_fullStr | The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm |
| title_full_unstemmed | The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm |
| title_short | The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm |
| title_sort | cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm |
| topic | emotions extinction fear vermis cerebellar hemisphere aversive conditioning |
| url | https://elifesciences.org/articles/46831 |
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