Profiling of idiopathic macular hole vitreous proteome identifies the role of extracellular matrix remodelling, epithelial–mesenchymal transformation and unfolded protein-response pathways

Profiling of idiopathic macular hole vitreous proteome identifies the role of extracellular matrix remodelling, epithelial–mesenchymal transformation and unfolded protein-response pathways

Purpose: To analyze and describe the proteome of the vitreous humour in eyes with idiopathic macular holes. Methods: We performed mass spectrometry (MS)-based label-free quantitative analysis of the vitreous proteome of idiopathic macular hole (IMH) and control donor vitreous. Comparative quantifi...

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Bibliographic Details
Main Authors: Sagnik Sen, Prithviraj Udaya, Jayapal J Maheshwari, Kim Ramasamy, Naresh B Kannan, Kuppamuthu Dharmalingam
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Indian Journal of Ophthalmology
Subjects:
donor vitreous
macular hole
mass spectrometry
pathogenesis
proteomics
Online Access:http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=5;spage=2027;epage=2040;aulast=Sen

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http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=5;spage=2027;epage=2040;aulast=Sen

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