Side effects and cognitive benefits of buspirone: A systematic review and meta-analysis
Buspirone, a 5-hydroxytryptamine 1A (5-HT1A) receptor agonist, has been investigated for its use in various diseases. However, knowledge about its side effects and potential cognitive benefits in different conditions is limited. Cognitive impairment is also a prevalent symptom in many diseases, yet...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024049491 |
| _version_ | 1827292704690667520 |
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| author | Yue Du Qing Li Yikai Dou Min Wang Yu Wang Yushun Yan Huanhuan Fan Xiao Yang Xiaohong Ma |
| author_facet | Yue Du Qing Li Yikai Dou Min Wang Yu Wang Yushun Yan Huanhuan Fan Xiao Yang Xiaohong Ma |
| author_sort | Yue Du |
| collection | DOAJ |
| description | Buspirone, a 5-hydroxytryptamine 1A (5-HT1A) receptor agonist, has been investigated for its use in various diseases. However, knowledge about its side effects and potential cognitive benefits in different conditions is limited. Cognitive impairment is also a prevalent symptom in many diseases, yet effective treatments are still lacking. Therefore, to explore the potential side effects of buspirone and the possible cognitive benefits of buspirone, we conducted a comprehensive search of several databases, including PubMed, Embase, Web of Science, Cochrane Review, Cochrane Trial, and ClinicalTrials.gov, to identify eligible randomized clinical trials. Our primary outcome measures included both side effects (adverse events) and cognitive benefits. For continuous variables, we utilized effect size with a 95% confidence interval (CI), whereas for dichotomous variables, we used odds ratios (OR) with a 95% CI. In total, 16 studies were included in this analysis, with 13 studies reporting on buspirone's side effects and 4 studies focusing on cognitive tasks. In terms of side effects, buspirone exhibited a higher rate of dizziness (OR = 4.66, 95% CI: 2.07–10.47), constipation (OR = 4.11, 95% CI: 1.34–12.55), and gastric distress (OR = 1.97, 95% CI: 1.03–3.78) than the placebo group. Regarding cognitive functions, buspirone showed significant benefits (g = 0.20, 95% CI: 0.06–0.34) while the placebo did not. Subgroup analysis indicated superior performance in visual learning and memory (g = 0.49, 95% CI: 0.21–0.78), logical reasoning (g = 0.42, 95% CI: 0.14–0.71), and attention (g = 0.37, 95% CI: 0.13–0.61) when compared to placebo. Our findings indicated that participants in the buspirone group experienced side effects of dizziness, constipation, and gastric distress in different diseases. Despite these adverse events, however, buspirone demonstrated significant cognitive benefits, particularly in the domains of visual learning and memory, logical reasoning, and attention. |
| first_indexed | 2024-04-24T13:10:23Z |
| format | Article |
| id | doaj.art-307951b5623e4111a1afb315a50e0e66 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:10:23Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-307951b5623e4111a1afb315a50e0e662024-04-05T04:41:15ZengElsevierHeliyon2405-84402024-04-01107e28918Side effects and cognitive benefits of buspirone: A systematic review and meta-analysisYue Du0Qing Li1Yikai Dou2Min Wang3Yu Wang4Yushun Yan5Huanhuan Fan6Xiao Yang7Xiaohong Ma8Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, ChinaMental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, ChinaMental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, ChinaMental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, ChinaMental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, ChinaMental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, ChinaMental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, ChinaCorresponding author. Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, China.; Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, ChinaCorresponding author. Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, China.; Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, ChinaBuspirone, a 5-hydroxytryptamine 1A (5-HT1A) receptor agonist, has been investigated for its use in various diseases. However, knowledge about its side effects and potential cognitive benefits in different conditions is limited. Cognitive impairment is also a prevalent symptom in many diseases, yet effective treatments are still lacking. Therefore, to explore the potential side effects of buspirone and the possible cognitive benefits of buspirone, we conducted a comprehensive search of several databases, including PubMed, Embase, Web of Science, Cochrane Review, Cochrane Trial, and ClinicalTrials.gov, to identify eligible randomized clinical trials. Our primary outcome measures included both side effects (adverse events) and cognitive benefits. For continuous variables, we utilized effect size with a 95% confidence interval (CI), whereas for dichotomous variables, we used odds ratios (OR) with a 95% CI. In total, 16 studies were included in this analysis, with 13 studies reporting on buspirone's side effects and 4 studies focusing on cognitive tasks. In terms of side effects, buspirone exhibited a higher rate of dizziness (OR = 4.66, 95% CI: 2.07–10.47), constipation (OR = 4.11, 95% CI: 1.34–12.55), and gastric distress (OR = 1.97, 95% CI: 1.03–3.78) than the placebo group. Regarding cognitive functions, buspirone showed significant benefits (g = 0.20, 95% CI: 0.06–0.34) while the placebo did not. Subgroup analysis indicated superior performance in visual learning and memory (g = 0.49, 95% CI: 0.21–0.78), logical reasoning (g = 0.42, 95% CI: 0.14–0.71), and attention (g = 0.37, 95% CI: 0.13–0.61) when compared to placebo. Our findings indicated that participants in the buspirone group experienced side effects of dizziness, constipation, and gastric distress in different diseases. Despite these adverse events, however, buspirone demonstrated significant cognitive benefits, particularly in the domains of visual learning and memory, logical reasoning, and attention.http://www.sciencedirect.com/science/article/pii/S2405844024049491BuspironeSide effectsCognitive benefits |
| spellingShingle | Yue Du Qing Li Yikai Dou Min Wang Yu Wang Yushun Yan Huanhuan Fan Xiao Yang Xiaohong Ma Side effects and cognitive benefits of buspirone: A systematic review and meta-analysis Heliyon Buspirone Side effects Cognitive benefits |
| title | Side effects and cognitive benefits of buspirone: A systematic review and meta-analysis |
| title_full | Side effects and cognitive benefits of buspirone: A systematic review and meta-analysis |
| title_fullStr | Side effects and cognitive benefits of buspirone: A systematic review and meta-analysis |
| title_full_unstemmed | Side effects and cognitive benefits of buspirone: A systematic review and meta-analysis |
| title_short | Side effects and cognitive benefits of buspirone: A systematic review and meta-analysis |
| title_sort | side effects and cognitive benefits of buspirone a systematic review and meta analysis |
| topic | Buspirone Side effects Cognitive benefits |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024049491 |
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