Effects of Aloe vera, Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides in Rat Model of Indomethacin-Induced Gastric Ulcer
Background: Evidences show that Aloe vera (A. vera), Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides may prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs). Objective: To examine the protective potential of these plants against indomethacin-induced gast...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2015-09-01
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| Series: | Journal of Medicinal Plants |
| Subjects: | |
| Online Access: | http://jmp.ir/article-1-987-en.html |
| _version_ | 1818647005332766720 |
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| author | Hasan Fallah Huseini Saeed Kianbakht Tayebeh Rajabian |
| author_facet | Hasan Fallah Huseini Saeed Kianbakht Tayebeh Rajabian |
| author_sort | Hasan Fallah Huseini |
| collection | DOAJ |
| description | Background: Evidences show that Aloe vera (A. vera), Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides may prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs).
Objective: To examine the protective potential of these plants against indomethacin-induced gastric ulcer in the rat.
Methods: Saline, A. vera leaf gel powder and 70% alcoholic extracts of the other 3 plants (100, 400, 800 mg/kg) and omeprazole (30 mg/kg) were gavaged to the groups of 10 animals for 4 consecutive days. Gastric ulcers were induced by the onetime gavage of indomethacin (30 mg/kg). On the fifth day, each group was pretreated with physiological saline as control, extract (100, 400 or 800 mg/kg) or omeprazole (30 mg/kg) 30 min before the indomethacin administration. The animals were killed 6 h after the indomethacin administration. The stomachs were removed, opened along the greater curvature and washed in physiological saline. A person unaware of the type of treatment received by the animals examined the stomachs under a 3-fold magnifier. The areas and lengths of hemorrhagic lesions induced by indomethacin were measured using a dial caliper and the sum of measurements for each animal was referred to as the ulcer index.
Results: All doses of the A. vera leaf gel powder and extracts reduced the ulcer index significantly compared to the control group (p < 0.05).
Conclusion: These plants have protective effect against NSAID-induced gastric ulcer in the rat. The A. vera leaf gel seems noticeably more effective than the other 3 plants in this respect. |
| first_indexed | 2024-12-17T00:55:39Z |
| format | Article |
| id | doaj.art-307b05f41a854be08902f7420a7e3425 |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-17T00:55:39Z |
| publishDate | 2015-09-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-307b05f41a854be08902f7420a7e34252022-12-21T22:09:36ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582015-09-0114555865Effects of Aloe vera, Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides in Rat Model of Indomethacin-Induced Gastric UlcerHasan Fallah Huseini0Saeed Kianbakht1Tayebeh Rajabian2 Institute of Medicinal Plants Institute of Medicinal Plants Shahed University Background: Evidences show that Aloe vera (A. vera), Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides may prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs). Objective: To examine the protective potential of these plants against indomethacin-induced gastric ulcer in the rat. Methods: Saline, A. vera leaf gel powder and 70% alcoholic extracts of the other 3 plants (100, 400, 800 mg/kg) and omeprazole (30 mg/kg) were gavaged to the groups of 10 animals for 4 consecutive days. Gastric ulcers were induced by the onetime gavage of indomethacin (30 mg/kg). On the fifth day, each group was pretreated with physiological saline as control, extract (100, 400 or 800 mg/kg) or omeprazole (30 mg/kg) 30 min before the indomethacin administration. The animals were killed 6 h after the indomethacin administration. The stomachs were removed, opened along the greater curvature and washed in physiological saline. A person unaware of the type of treatment received by the animals examined the stomachs under a 3-fold magnifier. The areas and lengths of hemorrhagic lesions induced by indomethacin were measured using a dial caliper and the sum of measurements for each animal was referred to as the ulcer index. Results: All doses of the A. vera leaf gel powder and extracts reduced the ulcer index significantly compared to the control group (p < 0.05). Conclusion: These plants have protective effect against NSAID-induced gastric ulcer in the rat. The A. vera leaf gel seems noticeably more effective than the other 3 plants in this respect.http://jmp.ir/article-1-987-en.htmlanti-ulcernon-steroidal anti-inflammatory drugrat. |
| spellingShingle | Hasan Fallah Huseini Saeed Kianbakht Tayebeh Rajabian Effects of Aloe vera, Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides in Rat Model of Indomethacin-Induced Gastric Ulcer Journal of Medicinal Plants anti-ulcer non-steroidal anti-inflammatory drug rat. |
| title | Effects of Aloe vera, Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides in Rat Model of Indomethacin-Induced Gastric Ulcer |
| title_full | Effects of Aloe vera, Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides in Rat Model of Indomethacin-Induced Gastric Ulcer |
| title_fullStr | Effects of Aloe vera, Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides in Rat Model of Indomethacin-Induced Gastric Ulcer |
| title_full_unstemmed | Effects of Aloe vera, Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides in Rat Model of Indomethacin-Induced Gastric Ulcer |
| title_short | Effects of Aloe vera, Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides in Rat Model of Indomethacin-Induced Gastric Ulcer |
| title_sort | effects of aloe vera camellia sinensis hibiscus sabdariffa and sophora alopecuroides in rat model of indomethacin induced gastric ulcer |
| topic | anti-ulcer non-steroidal anti-inflammatory drug rat. |
| url | http://jmp.ir/article-1-987-en.html |
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