Validity of fractional exhaled nitric oxide and small airway lung function measured by IOS in the diagnosis of cough variant asthma in preschool children with chronic cough
Abstract Background To investigate the role of combined impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) in the diagnosis of cough variant asthma (CVA) in preschool children. Methods A total of 197 preschool-aged children with chronic cough were selected from the paediatric outp...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
|
| Series: | Allergy, Asthma & Clinical Immunology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13223-023-00835-x |
| _version_ | 1797452222778310656 |
|---|---|
| author | Ying Hu Shouyan Zheng Zhiqiang Chen Dan Yu Tianxia Lai Yao Chen Wei Liao |
| author_facet | Ying Hu Shouyan Zheng Zhiqiang Chen Dan Yu Tianxia Lai Yao Chen Wei Liao |
| author_sort | Ying Hu |
| collection | DOAJ |
| description | Abstract Background To investigate the role of combined impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) in the diagnosis of cough variant asthma (CVA) in preschool children. Methods A total of 197 preschool-aged children with chronic cough were selected from the paediatric outpatient clinic. Allergy histories were collected for all children along with IOS and FeNO. Paediatric respiratory specialists divided the children into a CVA group (n = 90) and a noncough variant asthma (nCVA) group (n = 107) according to the diagnostic criteria for CVA After diagnostic treatment, the correlation between the FeNO and IOS values and the diagnosis in the two groups was analysed, and the area under the curve (AUC) of each index was calculated. Results (1) X5 was significantly different between the CVA group and the nCVA group (− 4.22 vs. − 3.64, p < 0.001), as was the FeNO value (29.07 vs. 16.64, p < 0.001). (2) Receiver operating characteristic (ROC) analysis showed that the AUCs of FeNO alone and X5 alone were 0.779 and 0.657, respectively, while the AUC of FeNO (cut-off value of 18 ppb) plus X5 (cut-off value of -4.15 cmH2O/(l/s)) reached 0.809. Conclusions Children with CVA may have small airway dysfunction at an early stage. For preschool children with chronic cough, the combination of FeNO and X5 can better identify those with CVA. Trial registration number: This trial was registered with and approved by the Chinese Clinical Trial Registry, with registration number ChiCTRcRRC-17011738, and was reviewed and approved by the Ethics Committee of Southwest Hospital. |
| first_indexed | 2024-03-09T15:05:40Z |
| format | Article |
| id | doaj.art-307b88c823b2461d988c2c6dda60118a |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-03-09T15:05:40Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-307b88c823b2461d988c2c6dda60118a2023-11-26T13:39:00ZengBMCAllergy, Asthma & Clinical Immunology1710-14922023-09-011911810.1186/s13223-023-00835-xValidity of fractional exhaled nitric oxide and small airway lung function measured by IOS in the diagnosis of cough variant asthma in preschool children with chronic coughYing Hu0Shouyan Zheng1Zhiqiang Chen2Dan Yu3Tianxia Lai4Yao Chen5Wei Liao6Department of Pediatrics, The First Affiliated Hospital of Army Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Army Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Army Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Army Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Army Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Army Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Army Medical UniversityAbstract Background To investigate the role of combined impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) in the diagnosis of cough variant asthma (CVA) in preschool children. Methods A total of 197 preschool-aged children with chronic cough were selected from the paediatric outpatient clinic. Allergy histories were collected for all children along with IOS and FeNO. Paediatric respiratory specialists divided the children into a CVA group (n = 90) and a noncough variant asthma (nCVA) group (n = 107) according to the diagnostic criteria for CVA After diagnostic treatment, the correlation between the FeNO and IOS values and the diagnosis in the two groups was analysed, and the area under the curve (AUC) of each index was calculated. Results (1) X5 was significantly different between the CVA group and the nCVA group (− 4.22 vs. − 3.64, p < 0.001), as was the FeNO value (29.07 vs. 16.64, p < 0.001). (2) Receiver operating characteristic (ROC) analysis showed that the AUCs of FeNO alone and X5 alone were 0.779 and 0.657, respectively, while the AUC of FeNO (cut-off value of 18 ppb) plus X5 (cut-off value of -4.15 cmH2O/(l/s)) reached 0.809. Conclusions Children with CVA may have small airway dysfunction at an early stage. For preschool children with chronic cough, the combination of FeNO and X5 can better identify those with CVA. Trial registration number: This trial was registered with and approved by the Chinese Clinical Trial Registry, with registration number ChiCTRcRRC-17011738, and was reviewed and approved by the Ethics Committee of Southwest Hospital.https://doi.org/10.1186/s13223-023-00835-xChronic coughCough variant asthmaFractional concentration of exhaled nitric oxidePreschool childrenSmall airway lung function |
| spellingShingle | Ying Hu Shouyan Zheng Zhiqiang Chen Dan Yu Tianxia Lai Yao Chen Wei Liao Validity of fractional exhaled nitric oxide and small airway lung function measured by IOS in the diagnosis of cough variant asthma in preschool children with chronic cough Allergy, Asthma & Clinical Immunology Chronic cough Cough variant asthma Fractional concentration of exhaled nitric oxide Preschool children Small airway lung function |
| title | Validity of fractional exhaled nitric oxide and small airway lung function measured by IOS in the diagnosis of cough variant asthma in preschool children with chronic cough |
| title_full | Validity of fractional exhaled nitric oxide and small airway lung function measured by IOS in the diagnosis of cough variant asthma in preschool children with chronic cough |
| title_fullStr | Validity of fractional exhaled nitric oxide and small airway lung function measured by IOS in the diagnosis of cough variant asthma in preschool children with chronic cough |
| title_full_unstemmed | Validity of fractional exhaled nitric oxide and small airway lung function measured by IOS in the diagnosis of cough variant asthma in preschool children with chronic cough |
| title_short | Validity of fractional exhaled nitric oxide and small airway lung function measured by IOS in the diagnosis of cough variant asthma in preschool children with chronic cough |
| title_sort | validity of fractional exhaled nitric oxide and small airway lung function measured by ios in the diagnosis of cough variant asthma in preschool children with chronic cough |
| topic | Chronic cough Cough variant asthma Fractional concentration of exhaled nitric oxide Preschool children Small airway lung function |
| url | https://doi.org/10.1186/s13223-023-00835-x |
| work_keys_str_mv | AT yinghu validityoffractionalexhalednitricoxideandsmallairwaylungfunctionmeasuredbyiosinthediagnosisofcoughvariantasthmainpreschoolchildrenwithchroniccough AT shouyanzheng validityoffractionalexhalednitricoxideandsmallairwaylungfunctionmeasuredbyiosinthediagnosisofcoughvariantasthmainpreschoolchildrenwithchroniccough AT zhiqiangchen validityoffractionalexhalednitricoxideandsmallairwaylungfunctionmeasuredbyiosinthediagnosisofcoughvariantasthmainpreschoolchildrenwithchroniccough AT danyu validityoffractionalexhalednitricoxideandsmallairwaylungfunctionmeasuredbyiosinthediagnosisofcoughvariantasthmainpreschoolchildrenwithchroniccough AT tianxialai validityoffractionalexhalednitricoxideandsmallairwaylungfunctionmeasuredbyiosinthediagnosisofcoughvariantasthmainpreschoolchildrenwithchroniccough AT yaochen validityoffractionalexhalednitricoxideandsmallairwaylungfunctionmeasuredbyiosinthediagnosisofcoughvariantasthmainpreschoolchildrenwithchroniccough AT weiliao validityoffractionalexhalednitricoxideandsmallairwaylungfunctionmeasuredbyiosinthediagnosisofcoughvariantasthmainpreschoolchildrenwithchroniccough |