Association between Chorioamnionitis Severity and Procalcitonin Levels in Umbilical Venous Blood
Background: Procalcitonin can effectively differentiate between bacterial sepsis and a systemic inflammatory response syndrome of noninfectious origins in the adult. However, the usefulness of procalcitonin in perinatal field is not determined. Thus, the purpose of this study was to determine whethe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2022-07-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/49/7/10.31083/j.ceog4907160 |
| _version_ | 1828399416895078400 |
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| author | Masatoki Kaneko Junsuke Muraoka Naoshi Yamada Yuki Kodama |
| author_facet | Masatoki Kaneko Junsuke Muraoka Naoshi Yamada Yuki Kodama |
| author_sort | Masatoki Kaneko |
| collection | DOAJ |
| description | Background: Procalcitonin can effectively differentiate between bacterial sepsis and a systemic inflammatory response syndrome of noninfectious origins in the adult. However, the usefulness of procalcitonin in perinatal field is not determined. Thus, the purpose of this study was to determine whether procalcitonin levels in the umbilical blood reflect the severity of chorioamnionitis and to assess their correlation with perinatal outcomes. Methods: A retrospective study was conducted in 145 pregnant women with singleton pregnancies and their neonates at a tertiary center between September 2010 and March 2013. Procalcitonin levels in the umbilical blood were measured by an immunoluminometric assay. The severity of chorioamnionitis was classified by the histological stage and grade for maternal and fetal inflammatory responses. Procalcitonin levels were evaluated according to the severity of chorioamnionitis; and the association with neonatal sepsis, intraventricular hemorrhage (IVH), neonatal death within 28 days of life, and periventricular leukomalacia was investigated. Results: In total, 28 women (19%) had chorioamnionitis, of which 21 (75%) delivered at less than 34 weeks of gestation. Fetal response in those with chorioamnionitis was correlated with maternal response. Procalcitonin levels in the group with fetal stage 2 and 3 or grade 2 responses were significantly higher than those infants with any other stage or grade. The frequency of neonatal sepsis, IVH stage III or IV, and neonatal death significantly increased (p < 0.01), when a Procalcitonin level of ≥2 ng/mL was obtained. Conclusions: Procalcitonin levels in the umbilical blood reflect the severity of chorioamnionitis and are associated with neonatal outcomes such as neonatal sepsis, neonatal death, and severe IVH. When PCT level in umbilical venous blood show the high value of ≥2 ng/mL, it might be required that antibiotics therapy is initiated immediately after birth. |
| first_indexed | 2024-12-10T09:16:16Z |
| format | Article |
| id | doaj.art-307bcc3c154d47bb800ca1b5559cbd74 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-12-10T09:16:16Z |
| publishDate | 2022-07-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-307bcc3c154d47bb800ca1b5559cbd742022-12-22T01:54:51ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-07-0149716010.31083/j.ceog4907160S0390-6663(22)01846-2Association between Chorioamnionitis Severity and Procalcitonin Levels in Umbilical Venous BloodMasatoki Kaneko0Junsuke Muraoka1Naoshi Yamada2Yuki Kodama3Department of Obstetrics and Gynecology, University of Miyazaki, 889-1692 Miyazaki, JapanDepartment of Obstetrics and Gynecology, University of Miyazaki, 889-1692 Miyazaki, JapanDepartment of Obstetrics and Gynecology, University of Miyazaki, 889-1692 Miyazaki, JapanDepartment of Obstetrics and Gynecology, University of Miyazaki, 889-1692 Miyazaki, JapanBackground: Procalcitonin can effectively differentiate between bacterial sepsis and a systemic inflammatory response syndrome of noninfectious origins in the adult. However, the usefulness of procalcitonin in perinatal field is not determined. Thus, the purpose of this study was to determine whether procalcitonin levels in the umbilical blood reflect the severity of chorioamnionitis and to assess their correlation with perinatal outcomes. Methods: A retrospective study was conducted in 145 pregnant women with singleton pregnancies and their neonates at a tertiary center between September 2010 and March 2013. Procalcitonin levels in the umbilical blood were measured by an immunoluminometric assay. The severity of chorioamnionitis was classified by the histological stage and grade for maternal and fetal inflammatory responses. Procalcitonin levels were evaluated according to the severity of chorioamnionitis; and the association with neonatal sepsis, intraventricular hemorrhage (IVH), neonatal death within 28 days of life, and periventricular leukomalacia was investigated. Results: In total, 28 women (19%) had chorioamnionitis, of which 21 (75%) delivered at less than 34 weeks of gestation. Fetal response in those with chorioamnionitis was correlated with maternal response. Procalcitonin levels in the group with fetal stage 2 and 3 or grade 2 responses were significantly higher than those infants with any other stage or grade. The frequency of neonatal sepsis, IVH stage III or IV, and neonatal death significantly increased (p < 0.01), when a Procalcitonin level of ≥2 ng/mL was obtained. Conclusions: Procalcitonin levels in the umbilical blood reflect the severity of chorioamnionitis and are associated with neonatal outcomes such as neonatal sepsis, neonatal death, and severe IVH. When PCT level in umbilical venous blood show the high value of ≥2 ng/mL, it might be required that antibiotics therapy is initiated immediately after birth.https://www.imrpress.com/journal/CEOG/49/7/10.31083/j.ceog4907160chorioamnionitisintraventricular hemorrhageneonatal sepsisneonatal deathprocalcitoninprematurityperiventricular leukomalacia |
| spellingShingle | Masatoki Kaneko Junsuke Muraoka Naoshi Yamada Yuki Kodama Association between Chorioamnionitis Severity and Procalcitonin Levels in Umbilical Venous Blood Clinical and Experimental Obstetrics & Gynecology chorioamnionitis intraventricular hemorrhage neonatal sepsis neonatal death procalcitonin prematurity periventricular leukomalacia |
| title | Association between Chorioamnionitis Severity and Procalcitonin Levels in Umbilical Venous Blood |
| title_full | Association between Chorioamnionitis Severity and Procalcitonin Levels in Umbilical Venous Blood |
| title_fullStr | Association between Chorioamnionitis Severity and Procalcitonin Levels in Umbilical Venous Blood |
| title_full_unstemmed | Association between Chorioamnionitis Severity and Procalcitonin Levels in Umbilical Venous Blood |
| title_short | Association between Chorioamnionitis Severity and Procalcitonin Levels in Umbilical Venous Blood |
| title_sort | association between chorioamnionitis severity and procalcitonin levels in umbilical venous blood |
| topic | chorioamnionitis intraventricular hemorrhage neonatal sepsis neonatal death procalcitonin prematurity periventricular leukomalacia |
| url | https://www.imrpress.com/journal/CEOG/49/7/10.31083/j.ceog4907160 |
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