The Matter of Kidney Biopsy in Monoclonal Gammopathy of Renal Significance: A Case Report of a New Pattern of Immunoglobulin-Storing Histiocytosis
Monoclonal gammopathy of renal significance (MGRS) represents a group of disorders, characterized by paraproteinemia which causes renal damage. These disorders never meet the diagnostic criteria for multiple myeloma (MM) or lymphoproliferative disease. Crystal-storing histiocytosis is one of the rar...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-12-01
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| Series: | Case Reports in Nephrology and Dialysis |
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| Online Access: | https://beta.karger.com/Article/FullText/533913 |
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| author | Paolo Randone Manuel Burdese Antonella Barreca Stefania Oliva Enrico Sanna Isabella Abbasciano Patrizia Anania Elena Boaglio Luigi Biancone |
| author_facet | Paolo Randone Manuel Burdese Antonella Barreca Stefania Oliva Enrico Sanna Isabella Abbasciano Patrizia Anania Elena Boaglio Luigi Biancone |
| author_sort | Paolo Randone |
| collection | DOAJ |
| description | Monoclonal gammopathy of renal significance (MGRS) represents a group of disorders, characterized by paraproteinemia which causes renal damage. These disorders never meet the diagnostic criteria for multiple myeloma (MM) or lymphoproliferative disease. Crystal-storing histiocytosis is one of the rarest patterns of MGRS, characterized by an accumulation of light chains of crystals within histiocyte’s cytoplasm, located in bone marrow or other extramedullary sites such as the kidney, cornea, or thyme. A very few cases have been described as immunoglobulin-storing histiocytosis (IgSH) without evidence of crystals. In the recent literature, only 3 cases of IgSH have been described so far, none renal. In all cases, these very peculiar histopathological patterns are associated with lymphoproliferative or plasma cellular disorders. Here, we report a very unusual IgSH pattern in a kidney biopsy, which led to prompt detection and early therapeutic intervention, in a patient with otherwise misdiagnosed MGRS. |
| first_indexed | 2024-03-08T14:47:45Z |
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| id | doaj.art-307c1a9e07944db0a0095122f1b9d34f |
| institution | Directory Open Access Journal |
| issn | 2296-9705 |
| language | English |
| last_indexed | 2024-03-08T14:47:45Z |
| publishDate | 2023-12-01 |
| publisher | Karger Publishers |
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| series | Case Reports in Nephrology and Dialysis |
| spelling | doaj.art-307c1a9e07944db0a0095122f1b9d34f2024-01-11T08:00:57ZengKarger PublishersCase Reports in Nephrology and Dialysis2296-97052023-12-0113119119610.1159/000533913533913The Matter of Kidney Biopsy in Monoclonal Gammopathy of Renal Significance: A Case Report of a New Pattern of Immunoglobulin-Storing HistiocytosisPaolo Randone0Manuel Burdese1Antonella Barreca2Stefania Oliva3Enrico Sanna4Isabella Abbasciano5Patrizia Anania6Elena Boaglio7Luigi Biancone8Division of Nephrology Dialysis and Transplantation, Renal Transplantation Center, “A. Vercellone,” Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, ItalyDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, “A. Vercellone,” Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, ItalyDivision of Pathology, Città della Salute e della Scienza Hospital, University of Turin, Turin, ItalyMyeloma Unit, Division of Hematology, Città della Salute e della Scienza Hospital, University of Turin, Turin, ItalyDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, “A. Vercellone,” Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, ItalyDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, “A. Vercellone,” Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, ItalyDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, “A. Vercellone,” Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, ItalyDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, “A. Vercellone,” Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, ItalyDivision of Nephrology Dialysis and Transplantation, Renal Transplantation Center, “A. Vercellone,” Città della Salute e della Scienza Hospital and Department of Medical Sciences, University of Turin, Turin, ItalyMonoclonal gammopathy of renal significance (MGRS) represents a group of disorders, characterized by paraproteinemia which causes renal damage. These disorders never meet the diagnostic criteria for multiple myeloma (MM) or lymphoproliferative disease. Crystal-storing histiocytosis is one of the rarest patterns of MGRS, characterized by an accumulation of light chains of crystals within histiocyte’s cytoplasm, located in bone marrow or other extramedullary sites such as the kidney, cornea, or thyme. A very few cases have been described as immunoglobulin-storing histiocytosis (IgSH) without evidence of crystals. In the recent literature, only 3 cases of IgSH have been described so far, none renal. In all cases, these very peculiar histopathological patterns are associated with lymphoproliferative or plasma cellular disorders. Here, we report a very unusual IgSH pattern in a kidney biopsy, which led to prompt detection and early therapeutic intervention, in a patient with otherwise misdiagnosed MGRS.https://beta.karger.com/Article/FullText/533913monoclonal gammopathy of renal significancecrystal-storing histiocytosisimmunoglobulin-storing histiocytosismultiple myeloma |
| spellingShingle | Paolo Randone Manuel Burdese Antonella Barreca Stefania Oliva Enrico Sanna Isabella Abbasciano Patrizia Anania Elena Boaglio Luigi Biancone The Matter of Kidney Biopsy in Monoclonal Gammopathy of Renal Significance: A Case Report of a New Pattern of Immunoglobulin-Storing Histiocytosis Case Reports in Nephrology and Dialysis monoclonal gammopathy of renal significance crystal-storing histiocytosis immunoglobulin-storing histiocytosis multiple myeloma |
| title | The Matter of Kidney Biopsy in Monoclonal Gammopathy of Renal Significance: A Case Report of a New Pattern of Immunoglobulin-Storing Histiocytosis |
| title_full | The Matter of Kidney Biopsy in Monoclonal Gammopathy of Renal Significance: A Case Report of a New Pattern of Immunoglobulin-Storing Histiocytosis |
| title_fullStr | The Matter of Kidney Biopsy in Monoclonal Gammopathy of Renal Significance: A Case Report of a New Pattern of Immunoglobulin-Storing Histiocytosis |
| title_full_unstemmed | The Matter of Kidney Biopsy in Monoclonal Gammopathy of Renal Significance: A Case Report of a New Pattern of Immunoglobulin-Storing Histiocytosis |
| title_short | The Matter of Kidney Biopsy in Monoclonal Gammopathy of Renal Significance: A Case Report of a New Pattern of Immunoglobulin-Storing Histiocytosis |
| title_sort | matter of kidney biopsy in monoclonal gammopathy of renal significance a case report of a new pattern of immunoglobulin storing histiocytosis |
| topic | monoclonal gammopathy of renal significance crystal-storing histiocytosis immunoglobulin-storing histiocytosis multiple myeloma |
| url | https://beta.karger.com/Article/FullText/533913 |
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