Asymmetrical Polymer Vesicles for Drug delivery and Other Applications
Scientists have been attracted by polymersomes as versatile drug delivery systems since the last two decades. Polymersomes have the potential to be versatile drug delivery systems because of their tunable membrane formulations, stabilities in vivo, various physicochemical properties, controlled rele...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2017-06-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2017.00374/full |
| _version_ | 1818981578083139584 |
|---|---|
| author | Yi Zhao Xiaoming Li Xiaotian Zhao Yunqi Yang Hui Li Xinbo Zhou Weien Yuan |
| author_facet | Yi Zhao Xiaoming Li Xiaotian Zhao Yunqi Yang Hui Li Xinbo Zhou Weien Yuan |
| author_sort | Yi Zhao |
| collection | DOAJ |
| description | Scientists have been attracted by polymersomes as versatile drug delivery systems since the last two decades. Polymersomes have the potential to be versatile drug delivery systems because of their tunable membrane formulations, stabilities in vivo, various physicochemical properties, controlled release mechanisms, targeting abilities, and capacities to encapsulate a wide range of drugs and other molecules. Asymmetrical polymersomes are nano- to micro-sized polymeric capsules with asymmetrical membranes, which means, they have different outer and inner coronas so that they can exhibit better endocytosis rate and endosomal escape ability than other polymeric systems with symmetrical membranes. Hence, asymmetrical polymersomes are highly promising as self-assembled nano-delivery systems in the future for in vivo therapeutics delivery and diagnostic imaging applications. In this review, we prepared a summary about recent research progresses of asymmetrical polymersomes in the following aspects: synthesis, preparation, applications in drug delivery and others. |
| first_indexed | 2024-12-20T17:33:33Z |
| format | Article |
| id | doaj.art-307d83d7ec3e4c26b6bc42cd397597c6 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T17:33:33Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-307d83d7ec3e4c26b6bc42cd397597c62022-12-21T19:31:17ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122017-06-01810.3389/fphar.2017.00374226362Asymmetrical Polymer Vesicles for Drug delivery and Other ApplicationsYi Zhao0Xiaoming Li1Xiaotian Zhao2Yunqi Yang3Hui Li4Xinbo Zhou5Weien Yuan6School of Pharmacy, Shanghai Jiao Tong UniversityShanghai, ChinaSchool of Pharmacy, Shanghai Jiao Tong UniversityShanghai, ChinaSchool of Pharmacy, Shanghai Jiao Tong UniversityShanghai, ChinaSchool of Pharmacy, Shanghai Jiao Tong UniversityShanghai, ChinaSchool of Medicine, University of California, San FranciscoSan Francisco, CA, United StatesLaboratory of Computer-Aided Drug Design and Discovery, Beijing Institute of Pharmacology and ToxicologyBeijing, ChinaSchool of Pharmacy, Shanghai Jiao Tong UniversityShanghai, ChinaScientists have been attracted by polymersomes as versatile drug delivery systems since the last two decades. Polymersomes have the potential to be versatile drug delivery systems because of their tunable membrane formulations, stabilities in vivo, various physicochemical properties, controlled release mechanisms, targeting abilities, and capacities to encapsulate a wide range of drugs and other molecules. Asymmetrical polymersomes are nano- to micro-sized polymeric capsules with asymmetrical membranes, which means, they have different outer and inner coronas so that they can exhibit better endocytosis rate and endosomal escape ability than other polymeric systems with symmetrical membranes. Hence, asymmetrical polymersomes are highly promising as self-assembled nano-delivery systems in the future for in vivo therapeutics delivery and diagnostic imaging applications. In this review, we prepared a summary about recent research progresses of asymmetrical polymersomes in the following aspects: synthesis, preparation, applications in drug delivery and others.http://journal.frontiersin.org/article/10.3389/fphar.2017.00374/fullasymmetrical polymer vesicledrug deliveryself-assemblenano-delivery vesicles |
| spellingShingle | Yi Zhao Xiaoming Li Xiaotian Zhao Yunqi Yang Hui Li Xinbo Zhou Weien Yuan Asymmetrical Polymer Vesicles for Drug delivery and Other Applications Frontiers in Pharmacology asymmetrical polymer vesicle drug delivery self-assemble nano-delivery vesicles |
| title | Asymmetrical Polymer Vesicles for Drug delivery and Other Applications |
| title_full | Asymmetrical Polymer Vesicles for Drug delivery and Other Applications |
| title_fullStr | Asymmetrical Polymer Vesicles for Drug delivery and Other Applications |
| title_full_unstemmed | Asymmetrical Polymer Vesicles for Drug delivery and Other Applications |
| title_short | Asymmetrical Polymer Vesicles for Drug delivery and Other Applications |
| title_sort | asymmetrical polymer vesicles for drug delivery and other applications |
| topic | asymmetrical polymer vesicle drug delivery self-assemble nano-delivery vesicles |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2017.00374/full |
| work_keys_str_mv | AT yizhao asymmetricalpolymervesiclesfordrugdeliveryandotherapplications AT xiaomingli asymmetricalpolymervesiclesfordrugdeliveryandotherapplications AT xiaotianzhao asymmetricalpolymervesiclesfordrugdeliveryandotherapplications AT yunqiyang asymmetricalpolymervesiclesfordrugdeliveryandotherapplications AT huili asymmetricalpolymervesiclesfordrugdeliveryandotherapplications AT xinbozhou asymmetricalpolymervesiclesfordrugdeliveryandotherapplications AT weienyuan asymmetricalpolymervesiclesfordrugdeliveryandotherapplications |