Scabies in Koranic schools in Dakar, Senegal: Comparison of two therapeutic modalities
Background: In 2017, WHO recognized scabies as a neglected tropical disease. The optimal treatment is not well defined in some communities. Objective: This study aimed to compare ivermectin and benzyl benzoate in the treatment of scabies in Koranic schools (or "daara") in Dakar (region)....
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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YCAB Publisher
2021-12-01
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| Series: | Public Health of Indonesia |
| Subjects: | |
| Online Access: | https://stikbar.org/ycabpublisher/index.php/PHI/article/view/456 |
| _version_ | 1797988813236076544 |
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| author | Ly Fatimata Faye Adama Wone Issa Lelo Souleye Diouf Astou Koundio Abou Ndiaye Diop Mame Tene Gueye Diagne Fatou Deh Aminata Faye Babacar Toure Fall Awa Oumar Mahé Antoine Tall Dia Anta |
| author_facet | Ly Fatimata Faye Adama Wone Issa Lelo Souleye Diouf Astou Koundio Abou Ndiaye Diop Mame Tene Gueye Diagne Fatou Deh Aminata Faye Babacar Toure Fall Awa Oumar Mahé Antoine Tall Dia Anta |
| author_sort | Ly Fatimata |
| collection | DOAJ |
| description | Background: In 2017, WHO recognized scabies as a neglected tropical disease. The optimal treatment is not well defined in some communities.
Objective: This study aimed to compare ivermectin and benzyl benzoate in the treatment of scabies in Koranic schools (or "daara") in Dakar (region).
Methods: This was a prospective randomized trial conducted from January to October 2018 in Senegal. Any resident living in the selected "daara" and diagnosed with scabies was included. The administered treatments were benzyl benzoate (BB) or ivermectin. At the outset, if one case of scabies was diagnosed, all residents received treatment. Ivermectin was given at the dose of 200 mg/kg. The same treatment was repeated on day 7 for each group, the endpoint was at D14, and the data were analyzed with STATA 14.
Results: Fifteen "daara" were included. Of the 959 residents, 70 were diagnosed with scabies: prevalence of 7.29%. All patients except one were male; the mean age was 9.98 years (4-17). At D14, in the BB arm, cure rate was 42.85% (n = 15) while in the ivermectin arm, this rate was 5.71% (n = 2) with a significant difference (p = 0.01). On D28, the cure rate was still higher in the BB group 57.14 (n=20) versus ivermectin 21.42 (n = 6) with a significant difference (p = 0.004). On D42, all patients except eight were cured. At D14, we found a link between the cure rate, the number of people in the room (p = 0.01), and the number of showers per week (p = 0.01) but no link with the number of people per "daara" (p = 0.163). At D28, we found a link between the cure rate, the number of people sleeping in the room (p = 0.03), and the number of showers per week (p = 0.01) but not with the number of people per "daara" (p = 0.07).
Conclusion: In Koranic schools, the cure rate is higher with benzyl benzoate compared to ivermectin. |
| first_indexed | 2024-04-11T08:10:08Z |
| format | Article |
| id | doaj.art-307d8d3362974c349f4f3b41d7c9fc72 |
| institution | Directory Open Access Journal |
| issn | 2528-1542 2477-1570 |
| language | English |
| last_indexed | 2024-04-11T08:10:08Z |
| publishDate | 2021-12-01 |
| publisher | YCAB Publisher |
| record_format | Article |
| series | Public Health of Indonesia |
| spelling | doaj.art-307d8d3362974c349f4f3b41d7c9fc722022-12-22T04:35:23ZengYCAB PublisherPublic Health of Indonesia2528-15422477-15702021-12-017417218110.36685/phi.v7i4.456327Scabies in Koranic schools in Dakar, Senegal: Comparison of two therapeutic modalitiesLy Fatimata0Faye Adama1Wone Issa2Lelo Souleye3Diouf Astou4Koundio Abou5Ndiaye Diop Mame Tene6Gueye Diagne Fatou7Deh Aminata8Faye Babacar9Toure Fall Awa Oumar10Mahé Antoine11Tall Dia Anta12Dermatology/STI, EPS 1 Institut d'Hygiène Sociale de Dakar, Senegal | University Cheikh Anta Diop of Dakar, SenegalDepartment of Public Health, University Cheikh Anta Diop of Dakar, SenegalUniversity Assane Seck de Ziguinchor, SenegalDepartment of Parasitology-Mycology, University Cheikh Anta Diop, Dakar, SenegalDermatology/STI, EPS 1 Institut d'Hygiène Sociale de Dakar, SenegalLaboratory of Hematology, National Teaching Hospital Aristide Le Dantec, Dakar, SenegalDermatology/STI, EPS 1 Institut d'Hygiène Sociale de Dakar, SenegalDermatology/STI, EPS 1 Institut d'Hygiène Sociale de Dakar, SenegalDermatology/STI, EPS 1 Institut d'Hygiène Sociale de Dakar, SenegalDepartment of Parasitology-Mycology, University Cheikh Anta Diop, Dakar, SenegalLaboratory of Hematology, National Teaching Hospital Aristide Le Dantec, Dakar, SenegalHí´pital Louis Pasteur, Colmar, FranceISED Institut Sante et Développement, Mbour, SenegalBackground: In 2017, WHO recognized scabies as a neglected tropical disease. The optimal treatment is not well defined in some communities. Objective: This study aimed to compare ivermectin and benzyl benzoate in the treatment of scabies in Koranic schools (or "daara") in Dakar (region). Methods: This was a prospective randomized trial conducted from January to October 2018 in Senegal. Any resident living in the selected "daara" and diagnosed with scabies was included. The administered treatments were benzyl benzoate (BB) or ivermectin. At the outset, if one case of scabies was diagnosed, all residents received treatment. Ivermectin was given at the dose of 200 mg/kg. The same treatment was repeated on day 7 for each group, the endpoint was at D14, and the data were analyzed with STATA 14. Results: Fifteen "daara" were included. Of the 959 residents, 70 were diagnosed with scabies: prevalence of 7.29%. All patients except one were male; the mean age was 9.98 years (4-17). At D14, in the BB arm, cure rate was 42.85% (n = 15) while in the ivermectin arm, this rate was 5.71% (n = 2) with a significant difference (p = 0.01). On D28, the cure rate was still higher in the BB group 57.14 (n=20) versus ivermectin 21.42 (n = 6) with a significant difference (p = 0.004). On D42, all patients except eight were cured. At D14, we found a link between the cure rate, the number of people in the room (p = 0.01), and the number of showers per week (p = 0.01) but no link with the number of people per "daara" (p = 0.163). At D28, we found a link between the cure rate, the number of people sleeping in the room (p = 0.03), and the number of showers per week (p = 0.01) but not with the number of people per "daara" (p = 0.07). Conclusion: In Koranic schools, the cure rate is higher with benzyl benzoate compared to ivermectin.https://stikbar.org/ycabpublisher/index.php/PHI/article/view/456scabiesivermectinbenzyl benzoatekoranic schoolsenegalprospective studies |
| spellingShingle | Ly Fatimata Faye Adama Wone Issa Lelo Souleye Diouf Astou Koundio Abou Ndiaye Diop Mame Tene Gueye Diagne Fatou Deh Aminata Faye Babacar Toure Fall Awa Oumar Mahé Antoine Tall Dia Anta Scabies in Koranic schools in Dakar, Senegal: Comparison of two therapeutic modalities Public Health of Indonesia scabies ivermectin benzyl benzoate koranic school senegal prospective studies |
| title | Scabies in Koranic schools in Dakar, Senegal: Comparison of two therapeutic modalities |
| title_full | Scabies in Koranic schools in Dakar, Senegal: Comparison of two therapeutic modalities |
| title_fullStr | Scabies in Koranic schools in Dakar, Senegal: Comparison of two therapeutic modalities |
| title_full_unstemmed | Scabies in Koranic schools in Dakar, Senegal: Comparison of two therapeutic modalities |
| title_short | Scabies in Koranic schools in Dakar, Senegal: Comparison of two therapeutic modalities |
| title_sort | scabies in koranic schools in dakar senegal comparison of two therapeutic modalities |
| topic | scabies ivermectin benzyl benzoate koranic school senegal prospective studies |
| url | https://stikbar.org/ycabpublisher/index.php/PHI/article/view/456 |
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