The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse Effects
Adverse effects are a common consequence of cytotoxic cancer treatments. Over the last two decades there have been significant advances in exploring the relationship between the gut microbiome and these adverse effects. Changes in the gut microbiome were shown in multiple clinical studies to be asso...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/17/4301 |
| _version_ | 1797582720738525184 |
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| author | Amanda S. Maddern Janet K. Coller Joanne M. Bowen Rachel J. Gibson |
| author_facet | Amanda S. Maddern Janet K. Coller Joanne M. Bowen Rachel J. Gibson |
| author_sort | Amanda S. Maddern |
| collection | DOAJ |
| description | Adverse effects are a common consequence of cytotoxic cancer treatments. Over the last two decades there have been significant advances in exploring the relationship between the gut microbiome and these adverse effects. Changes in the gut microbiome were shown in multiple clinical studies to be associated with the development of acute gastrointestinal adverse effects, including diarrhoea and mucositis. However, more recent studies showed that changes in the gut microbiome may also be associated with the long-term development of psychoneurological changes, cancer cachexia, and fatigue. Therefore, the aim of this review was to examine the literature to identify potential contributions and associations of the gut microbiome with the wide range of adverse effects from cytotoxic cancer treatments. |
| first_indexed | 2024-03-10T23:26:31Z |
| format | Article |
| id | doaj.art-307dfc29863d410988d5c5053e50b7ae |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T23:26:31Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-307dfc29863d410988d5c5053e50b7ae2023-11-19T07:55:53ZengMDPI AGCancers2072-66942023-08-011517430110.3390/cancers15174301The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse EffectsAmanda S. Maddern0Janet K. Coller1Joanne M. Bowen2Rachel J. Gibson3School of Allied Health Science and Practice, The University of Adelaide, Adelaide, SA 5005, AustraliaSchool of Biomedicine, The University of Adelaide, Adelaide, SA 5005, AustraliaSchool of Biomedicine, The University of Adelaide, Adelaide, SA 5005, AustraliaSchool of Allied Health Science and Practice, The University of Adelaide, Adelaide, SA 5005, AustraliaAdverse effects are a common consequence of cytotoxic cancer treatments. Over the last two decades there have been significant advances in exploring the relationship between the gut microbiome and these adverse effects. Changes in the gut microbiome were shown in multiple clinical studies to be associated with the development of acute gastrointestinal adverse effects, including diarrhoea and mucositis. However, more recent studies showed that changes in the gut microbiome may also be associated with the long-term development of psychoneurological changes, cancer cachexia, and fatigue. Therefore, the aim of this review was to examine the literature to identify potential contributions and associations of the gut microbiome with the wide range of adverse effects from cytotoxic cancer treatments.https://www.mdpi.com/2072-6694/15/17/4301gut microbiomechemotherapyradiotherapychemoradiotherapycancer treatmentadverse effects |
| spellingShingle | Amanda S. Maddern Janet K. Coller Joanne M. Bowen Rachel J. Gibson The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse Effects Cancers gut microbiome chemotherapy radiotherapy chemoradiotherapy cancer treatment adverse effects |
| title | The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse Effects |
| title_full | The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse Effects |
| title_fullStr | The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse Effects |
| title_full_unstemmed | The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse Effects |
| title_short | The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse Effects |
| title_sort | association between the gut microbiome and development and progression of cancer treatment adverse effects |
| topic | gut microbiome chemotherapy radiotherapy chemoradiotherapy cancer treatment adverse effects |
| url | https://www.mdpi.com/2072-6694/15/17/4301 |
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