Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats
Aluminum (Al) is a non-essential metal omnipresent in human life and is considered an environmental toxicant. Al increases reactive oxygen production and triggers immune responses, contributing to chronic systemic inflammation development. Here, we have tested whether an egg white hydrolysate (EWH)...
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MDPI AG
2022-11-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/12/1188 |
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| author | Caroline Silveira Martinez Jose Antonio Uranga-Ocio Franck Maciel Peçanha Dalton Valentim Vassallo Christopher Exley Marta Miguel-Castro Giulia Alessandra Wiggers |
| author_facet | Caroline Silveira Martinez Jose Antonio Uranga-Ocio Franck Maciel Peçanha Dalton Valentim Vassallo Christopher Exley Marta Miguel-Castro Giulia Alessandra Wiggers |
| author_sort | Caroline Silveira Martinez |
| collection | DOAJ |
| description | Aluminum (Al) is a non-essential metal omnipresent in human life and is considered an environmental toxicant. Al increases reactive oxygen production and triggers immune responses, contributing to chronic systemic inflammation development. Here, we have tested whether an egg white hydrolysate (EWH) with potential bioactive properties can protect against changes in reproductive function in rats exposed to long-term Al dietary levels at high and low doses. Male Wistar rats received orally: low aluminum level group—AlCl<sub>3</sub> at 8.3 mg/kg b.w. for 60 days with or without EWH (1 g/kg/day); high aluminum level group—AlCl<sub>3</sub> at 100 mg/kg b.w. for 42 days with or without EWH (1 g/kg/day). The co-administration of EWH prevented the increased Al deposition surrounding the germinative cells, reducing inflammation and oxidative stress in the reproductive organs. Furthermore, the daily supplementation with EWH maintained sperm production and sperm quality similar to those found in control animals, even after Al exposure at a high dietary contamination level. Altogether, our results suggest that EWH could be used as a protective agent against impairment in the reproductive system produced after long-term exposure to Al at low or high human dietary levels. |
| first_indexed | 2024-03-09T16:05:55Z |
| format | Article |
| id | doaj.art-307e65a37e824509bd5b7423e9d63730 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T16:05:55Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-307e65a37e824509bd5b7423e9d637302023-11-24T16:37:12ZengMDPI AGMetabolites2218-19892022-11-011212118810.3390/metabo12121188Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in RatsCaroline Silveira Martinez0Jose Antonio Uranga-Ocio1Franck Maciel Peçanha2Dalton Valentim Vassallo3Christopher Exley4Marta Miguel-Castro5Giulia Alessandra Wiggers6Graduate Program in Biochemistry and Multicentric Graduate Program in Physiological Sciences, Universidade Federal do Pampa, BR 472-Km 592, P.O. Box 118, Uruguaiana 97500-970, Rio Grande do Sul, BrazilDepartment of Ciencias Básicas de la Salud, Universidad Rey Juan Carlos, Avda. de Atenas s/n, 28032 Alcorcón, SpainGraduate Program in Biochemistry and Multicentric Graduate Program in Physiological Sciences, Universidade Federal do Pampa, BR 472-Km 592, P.O. Box 118, Uruguaiana 97500-970, Rio Grande do Sul, BrazilDepartments of Physiological Sciences, Universidade Federal do Espírito Santo, Av. Marechal Campos 1468, Vitória 29040-090, Espírito Santo, BrazilThe Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire ST5 5BG, UKBioactivity and Food Analysis Laboratory, Instituto de Investigación en Ciencias de la Alimentación, Nicolás Cabrera, 9, Campus Universitario de Cantoblanco, 28049 Madrid, SpainGraduate Program in Biochemistry and Multicentric Graduate Program in Physiological Sciences, Universidade Federal do Pampa, BR 472-Km 592, P.O. Box 118, Uruguaiana 97500-970, Rio Grande do Sul, BrazilAluminum (Al) is a non-essential metal omnipresent in human life and is considered an environmental toxicant. Al increases reactive oxygen production and triggers immune responses, contributing to chronic systemic inflammation development. Here, we have tested whether an egg white hydrolysate (EWH) with potential bioactive properties can protect against changes in reproductive function in rats exposed to long-term Al dietary levels at high and low doses. Male Wistar rats received orally: low aluminum level group—AlCl<sub>3</sub> at 8.3 mg/kg b.w. for 60 days with or without EWH (1 g/kg/day); high aluminum level group—AlCl<sub>3</sub> at 100 mg/kg b.w. for 42 days with or without EWH (1 g/kg/day). The co-administration of EWH prevented the increased Al deposition surrounding the germinative cells, reducing inflammation and oxidative stress in the reproductive organs. Furthermore, the daily supplementation with EWH maintained sperm production and sperm quality similar to those found in control animals, even after Al exposure at a high dietary contamination level. Altogether, our results suggest that EWH could be used as a protective agent against impairment in the reproductive system produced after long-term exposure to Al at low or high human dietary levels.https://www.mdpi.com/2218-1989/12/12/1188environmental contaminantheavy metalfunctional foodbioactive peptides |
| spellingShingle | Caroline Silveira Martinez Jose Antonio Uranga-Ocio Franck Maciel Peçanha Dalton Valentim Vassallo Christopher Exley Marta Miguel-Castro Giulia Alessandra Wiggers Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats Metabolites environmental contaminant heavy metal functional food bioactive peptides |
| title | Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats |
| title_full | Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats |
| title_fullStr | Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats |
| title_full_unstemmed | Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats |
| title_short | Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats |
| title_sort | dietary egg white hydrolysate prevents male reproductive dysfunction after long term exposure to aluminum in rats |
| topic | environmental contaminant heavy metal functional food bioactive peptides |
| url | https://www.mdpi.com/2218-1989/12/12/1188 |
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