Resting-state cortical hubs in youth organize into four categories
Summary: During childhood, neural systems supporting high-level cognitive processes undergo periods of rapid growth and refinement, which rely on the successful coordination of activation across the brain. Some coordination occurs via cortical hubs—brain regions that coactivate with functional netwo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723005326 |
| _version_ | 1797823753395109888 |
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| author | Damion V. Demeter Evan M. Gordon Tehila Nugiel AnnaCarolina Garza Tyler L. Larguinho Jessica A. Church |
| author_facet | Damion V. Demeter Evan M. Gordon Tehila Nugiel AnnaCarolina Garza Tyler L. Larguinho Jessica A. Church |
| author_sort | Damion V. Demeter |
| collection | DOAJ |
| description | Summary: During childhood, neural systems supporting high-level cognitive processes undergo periods of rapid growth and refinement, which rely on the successful coordination of activation across the brain. Some coordination occurs via cortical hubs—brain regions that coactivate with functional networks other than their own. Adult cortical hubs map into three distinct profiles, but less is known about hub categories during development, when critical improvement in cognition occurs. We identify four distinct hub categories in a large youth sample (n = 567, ages 8.5–17.2), each exhibiting more diverse connectivity profiles than adults. Youth hubs integrating control-sensory processing split into two distinct categories (visual control and auditory/motor control), whereas adult hubs unite under one. This split suggests a need for segregating sensory stimuli while functional networks are experiencing rapid development. Functional coactivation strength for youth control-processing hubs are associated with task performance, suggesting a specialized role in routing sensory information to and from the brain’s control system. |
| first_indexed | 2024-03-13T10:27:41Z |
| format | Article |
| id | doaj.art-307f9e9223044abc9bb4359e4d0b1de3 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-13T10:27:41Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-307f9e9223044abc9bb4359e4d0b1de32023-05-19T04:45:21ZengElsevierCell Reports2211-12472023-05-01425112521Resting-state cortical hubs in youth organize into four categoriesDamion V. Demeter0Evan M. Gordon1Tehila Nugiel2AnnaCarolina Garza3Tyler L. Larguinho4Jessica A. Church5Department of Cognitive Science, University of California San Diego, La Jolla, CA 92093, USA; Corresponding authorDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USACarolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Psychology, The University of Texas at Austin, Austin, TX 78712, USADepartment of Psychology, The University of Texas at Austin, Austin, TX 78712, USADepartment of Psychology, The University of Texas at Austin, Austin, TX 78712, USASummary: During childhood, neural systems supporting high-level cognitive processes undergo periods of rapid growth and refinement, which rely on the successful coordination of activation across the brain. Some coordination occurs via cortical hubs—brain regions that coactivate with functional networks other than their own. Adult cortical hubs map into three distinct profiles, but less is known about hub categories during development, when critical improvement in cognition occurs. We identify four distinct hub categories in a large youth sample (n = 567, ages 8.5–17.2), each exhibiting more diverse connectivity profiles than adults. Youth hubs integrating control-sensory processing split into two distinct categories (visual control and auditory/motor control), whereas adult hubs unite under one. This split suggests a need for segregating sensory stimuli while functional networks are experiencing rapid development. Functional coactivation strength for youth control-processing hubs are associated with task performance, suggesting a specialized role in routing sensory information to and from the brain’s control system.http://www.sciencedirect.com/science/article/pii/S2211124723005326CP: Neuroscience |
| spellingShingle | Damion V. Demeter Evan M. Gordon Tehila Nugiel AnnaCarolina Garza Tyler L. Larguinho Jessica A. Church Resting-state cortical hubs in youth organize into four categories Cell Reports CP: Neuroscience |
| title | Resting-state cortical hubs in youth organize into four categories |
| title_full | Resting-state cortical hubs in youth organize into four categories |
| title_fullStr | Resting-state cortical hubs in youth organize into four categories |
| title_full_unstemmed | Resting-state cortical hubs in youth organize into four categories |
| title_short | Resting-state cortical hubs in youth organize into four categories |
| title_sort | resting state cortical hubs in youth organize into four categories |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723005326 |
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