Topical Application of Capparis Spinosa Fruit Extract Lowers Blood Glucose Level.
Wounds are a nightmare for people with diabetes due to the fact that they tend to heal slowly or do not heal well. Blood glucose levels, a major contributor to wound complications, must be lowered to facilitate wound healing. A medicinal plant extract with known hypoglycemic properties can be of gr...
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| Format: | Article |
| Language: | English |
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Salahaddin University-Erbil
2023-10-01
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| Series: | Zanco Journal of Pure and Applied Sciences |
| Subjects: | |
| Online Access: | https://zancojournal.su.edu.krd/index.php/JPAS/article/view/801 |
| _version_ | 1827129085303717888 |
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| author | Maryam H. Alwan Zainab H. Alwan Ban A. Ghani |
| author_facet | Maryam H. Alwan Zainab H. Alwan Ban A. Ghani |
| author_sort | Maryam H. Alwan |
| collection | DOAJ |
| description |
Wounds are a nightmare for people with diabetes due to the fact that they tend to heal slowly or do not heal well. Blood glucose levels, a major contributor to wound complications, must be lowered to facilitate wound healing. A medicinal plant extract with known hypoglycemic properties can be of great opportunity in curing diabetic wounds. Capparis spinosa fruit has long been used as an anti-hyperglycemic food in traditional Middle Eastern herbalism. For the first time, the capacity of caper berries to lower blood glucose levels by direct local application to the wound was proved in this study. The study was conducted using 20 male Wistar rats. Each rat was given a single dose of Alloxan (150 mg/kg) intraperitoneally. Surgical incisional wounds with full-thickness skin and a length of 1.5 cm were made in the skin of each rat, then the rats were randomly divided into Group A: 10 rats with a daily local application of the extract on the wound. Group B: 10 rats with normal saline applied topically. Blood glucose levels were evaluated daily until the end of the trial. According to an independent t-test, there was a highly significant difference (p 0.01) in the mean values of blood glucose levels between groups A and B at three days and a significant difference (p 0.05) in blood glucose levels recorded at seven days' duration. The results provide support for the use of Capparis spinosa fruit extract in managing hyperglycemia and preventing the complications associated with it in diabetics
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| first_indexed | 2024-03-08T11:51:09Z |
| format | Article |
| id | doaj.art-3081255ca0e34fb88076b617207d8eda |
| institution | Directory Open Access Journal |
| issn | 2218-0230 2412-3986 |
| language | English |
| last_indexed | 2025-03-20T15:54:41Z |
| publishDate | 2023-10-01 |
| publisher | Salahaddin University-Erbil |
| record_format | Article |
| series | Zanco Journal of Pure and Applied Sciences |
| spelling | doaj.art-3081255ca0e34fb88076b617207d8eda2024-09-02T08:56:57ZengSalahaddin University-ErbilZanco Journal of Pure and Applied Sciences2218-02302412-39862023-10-0135510.21271/ZJPAS.35.5.13Topical Application of Capparis Spinosa Fruit Extract Lowers Blood Glucose Level.Maryam H. Alwan0Zainab H. Alwan1Ban A. Ghani2Department of Oral Diagnosis, College of Dentistry, Baghdad University, IraqDepartment of Pharmacology, Alnahrain University, Baghdad, IraqDepartment of Oral Diagnosis, College of Dentistry, Baghdad University, Iraq Wounds are a nightmare for people with diabetes due to the fact that they tend to heal slowly or do not heal well. Blood glucose levels, a major contributor to wound complications, must be lowered to facilitate wound healing. A medicinal plant extract with known hypoglycemic properties can be of great opportunity in curing diabetic wounds. Capparis spinosa fruit has long been used as an anti-hyperglycemic food in traditional Middle Eastern herbalism. For the first time, the capacity of caper berries to lower blood glucose levels by direct local application to the wound was proved in this study. The study was conducted using 20 male Wistar rats. Each rat was given a single dose of Alloxan (150 mg/kg) intraperitoneally. Surgical incisional wounds with full-thickness skin and a length of 1.5 cm were made in the skin of each rat, then the rats were randomly divided into Group A: 10 rats with a daily local application of the extract on the wound. Group B: 10 rats with normal saline applied topically. Blood glucose levels were evaluated daily until the end of the trial. According to an independent t-test, there was a highly significant difference (p 0.01) in the mean values of blood glucose levels between groups A and B at three days and a significant difference (p 0.05) in blood glucose levels recorded at seven days' duration. The results provide support for the use of Capparis spinosa fruit extract in managing hyperglycemia and preventing the complications associated with it in diabetics https://zancojournal.su.edu.krd/index.php/JPAS/article/view/801Capparis SpinosaCapparaceaediabeticCaper |
| spellingShingle | Maryam H. Alwan Zainab H. Alwan Ban A. Ghani Topical Application of Capparis Spinosa Fruit Extract Lowers Blood Glucose Level. Zanco Journal of Pure and Applied Sciences Capparis Spinosa Capparaceae diabetic Caper |
| title | Topical Application of Capparis Spinosa Fruit Extract Lowers Blood Glucose Level. |
| title_full | Topical Application of Capparis Spinosa Fruit Extract Lowers Blood Glucose Level. |
| title_fullStr | Topical Application of Capparis Spinosa Fruit Extract Lowers Blood Glucose Level. |
| title_full_unstemmed | Topical Application of Capparis Spinosa Fruit Extract Lowers Blood Glucose Level. |
| title_short | Topical Application of Capparis Spinosa Fruit Extract Lowers Blood Glucose Level. |
| title_sort | topical application of capparis spinosa fruit extract lowers blood glucose level |
| topic | Capparis Spinosa Capparaceae diabetic Caper |
| url | https://zancojournal.su.edu.krd/index.php/JPAS/article/view/801 |
| work_keys_str_mv | AT maryamhalwan topicalapplicationofcapparisspinosafruitextractlowersbloodglucoselevel AT zainabhalwan topicalapplicationofcapparisspinosafruitextractlowersbloodglucoselevel AT banaghani topicalapplicationofcapparisspinosafruitextractlowersbloodglucoselevel |