A long waiting time from diagnosis to treatment decreases the survival of non-small cell lung cancer patients with stage IA1: A retrospective study
ObjectiveThe prognostic effect of delayed treatment on stage IA1 non-small cell lung cancer (NSCLC) patients is still unclear. This study aimed to explore the association between the waiting time before treatment and the prognosis in stage IA1 NSCLC patients.MethodsEligible patients diagnosed with p...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.987075/full |
| _version_ | 1797998908622766080 |
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| author | Bin Liu Jia-Yi Qian Lei-Lei Wu Jun-Quan Zeng Shu-Quan Xu Jin-Hua Yuan Yong-Liang Zheng Dong Xie Xiaolu Chen Hai-Hong Yu Hai-Hong Yu |
| author_facet | Bin Liu Jia-Yi Qian Lei-Lei Wu Jun-Quan Zeng Shu-Quan Xu Jin-Hua Yuan Yong-Liang Zheng Dong Xie Xiaolu Chen Hai-Hong Yu Hai-Hong Yu |
| author_sort | Bin Liu |
| collection | DOAJ |
| description | ObjectiveThe prognostic effect of delayed treatment on stage IA1 non-small cell lung cancer (NSCLC) patients is still unclear. This study aimed to explore the association between the waiting time before treatment and the prognosis in stage IA1 NSCLC patients.MethodsEligible patients diagnosed with pathological stage IA1 NSCLC were included in this study. The clinical endpoints were overall survival (OS) and cancer-specific survival (CSS). The Kaplan-Meier method, the Log-rank test, univariable, and multivariable Cox regression analyses were used in this study. Propensity score matching was used to reduce the bias of data distribution.ResultsThere were eligible 957 patients in the study. The length of waiting time before treatment stratified the survival in patients [<3 months vs. ≥3-months, unadjusted hazard ratio (HR) = 0.481, P = 0.007; <2 months vs. ≥2-months, unadjusted HR = 0.564, P = 0.006; <1 month vs. ≥1-month, unadjusted HR = 0.537, P = 0.001]. The 5-year CSS rates were 95.0% and 77.0% in patients of waiting time within 3 months and over 3 months, respectively. After adjusting for other confounders, the waiting time was identified as an independent prognostic factor.ConclusionsA long waiting time before treatment may decrease the survival of stage IA1 NSCLC patients. We propose that the waiting time for those patients preferably is less than one month and should not exceed two months. |
| first_indexed | 2024-04-11T10:56:12Z |
| format | Article |
| id | doaj.art-3081414ac5a84d1e8f531dd3e2054059 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-11T10:56:12Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-3081414ac5a84d1e8f531dd3e20540592022-12-22T04:28:46ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-09-01910.3389/fsurg.2022.987075987075A long waiting time from diagnosis to treatment decreases the survival of non-small cell lung cancer patients with stage IA1: A retrospective studyBin Liu0Jia-Yi Qian1Lei-Lei Wu2Jun-Quan Zeng3Shu-Quan Xu4Jin-Hua Yuan5Yong-Liang Zheng6Dong Xie7Xiaolu Chen8Hai-Hong Yu9Hai-Hong Yu10Department of Oncology, The Affiliated Hospital of Jinggangshan University, Ji’an, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Oncology, The Affiliated Hospital of Jinggangshan University, Ji’an, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaDepartment of Oncology, The Affiliated Hospital of Jinggangshan University, Ji’an, ChinaDepartment of Oncology, The Affiliated Hospital of Jinggangshan University, Ji’an, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Respiratory and Critical Care, The Affiliated People’s Hospital of Ningbo University, Ningbo, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaSchool of Medicine, Jinggangshan University, Ji'an, ChinaObjectiveThe prognostic effect of delayed treatment on stage IA1 non-small cell lung cancer (NSCLC) patients is still unclear. This study aimed to explore the association between the waiting time before treatment and the prognosis in stage IA1 NSCLC patients.MethodsEligible patients diagnosed with pathological stage IA1 NSCLC were included in this study. The clinical endpoints were overall survival (OS) and cancer-specific survival (CSS). The Kaplan-Meier method, the Log-rank test, univariable, and multivariable Cox regression analyses were used in this study. Propensity score matching was used to reduce the bias of data distribution.ResultsThere were eligible 957 patients in the study. The length of waiting time before treatment stratified the survival in patients [<3 months vs. ≥3-months, unadjusted hazard ratio (HR) = 0.481, P = 0.007; <2 months vs. ≥2-months, unadjusted HR = 0.564, P = 0.006; <1 month vs. ≥1-month, unadjusted HR = 0.537, P = 0.001]. The 5-year CSS rates were 95.0% and 77.0% in patients of waiting time within 3 months and over 3 months, respectively. After adjusting for other confounders, the waiting time was identified as an independent prognostic factor.ConclusionsA long waiting time before treatment may decrease the survival of stage IA1 NSCLC patients. We propose that the waiting time for those patients preferably is less than one month and should not exceed two months.https://www.frontiersin.org/articles/10.3389/fsurg.2022.987075/fullnon-small cell lung cancerstage IA1delayed treatmentprognosissurgery |
| spellingShingle | Bin Liu Jia-Yi Qian Lei-Lei Wu Jun-Quan Zeng Shu-Quan Xu Jin-Hua Yuan Yong-Liang Zheng Dong Xie Xiaolu Chen Hai-Hong Yu Hai-Hong Yu A long waiting time from diagnosis to treatment decreases the survival of non-small cell lung cancer patients with stage IA1: A retrospective study Frontiers in Surgery non-small cell lung cancer stage IA1 delayed treatment prognosis surgery |
| title | A long waiting time from diagnosis to treatment decreases the survival of non-small cell lung cancer patients with stage IA1: A retrospective study |
| title_full | A long waiting time from diagnosis to treatment decreases the survival of non-small cell lung cancer patients with stage IA1: A retrospective study |
| title_fullStr | A long waiting time from diagnosis to treatment decreases the survival of non-small cell lung cancer patients with stage IA1: A retrospective study |
| title_full_unstemmed | A long waiting time from diagnosis to treatment decreases the survival of non-small cell lung cancer patients with stage IA1: A retrospective study |
| title_short | A long waiting time from diagnosis to treatment decreases the survival of non-small cell lung cancer patients with stage IA1: A retrospective study |
| title_sort | long waiting time from diagnosis to treatment decreases the survival of non small cell lung cancer patients with stage ia1 a retrospective study |
| topic | non-small cell lung cancer stage IA1 delayed treatment prognosis surgery |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.987075/full |
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