Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome
<em><strong>Objective(s):</strong></em> One of the common heterogeneous reproductive disorders in women of childbearing age is polycystic ovary syndrome (PCOS). It is characterized by lack of fertility due to anovulatory cycles, hyperandrogenemia, polycystic ovaries, hyperins...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-12-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_14029_079f70ecab79a8e4c29561a8eca4bdfc.pdf |
| _version_ | 1819031907075096576 |
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| author | Zahra Shaaban Arezoo Khoradmehr Amir Amiri-Yekta Mohammad Reza Jafarzadeh Shirazi Amin Tamadon |
| author_facet | Zahra Shaaban Arezoo Khoradmehr Amir Amiri-Yekta Mohammad Reza Jafarzadeh Shirazi Amin Tamadon |
| author_sort | Zahra Shaaban |
| collection | DOAJ |
| description | <em><strong>Objective(s):</strong></em> One of the common heterogeneous reproductive disorders in women of childbearing age is polycystic ovary syndrome (PCOS). It is characterized by lack of fertility due to anovulatory cycles, hyperandrogenemia, polycystic ovaries, hyperinsulinemia, and obesity. Both reproductive anomalies and metabolic disorders are involved in PCOS pathology. Although the role of increased levels of androgens in initiation of PCOS is almost proven, mechanisms of PCOS pathophysiology are not clear. Here we discuss roles of altered metabolic conditions, obesity, and chronic inflammation in PCOS pathophysiology.<br /><em><strong>Materials and Methods:</strong></em> In this review, we attempted to identify genes related to obesity and chronic inflammation aspects of PCOS and their physiological functions to explain the pathways that are regulated by these genes and can be a prominent function in PCOS predisposition. For this purpose, published articles and reviews dealing with genetic evaluation of PCOS in women in peer-reviewed journals in PubMed and Google Scholar databases were included in this review.<br /><em><strong>Results:</strong></em> Obesity and chronic inflammation are not prominent diagnostic features of PCOS, but they play an important role in exacerbating metabolic and hyperandrogenic states. ADIPOQ, FTO TGFβ, and DENND1A as the main obesity- and chronic inflammation-related genes have roles in PCOS pathophysiology.<br /><em><strong>Conclusion:</strong></em> It seems that genes related to obesity pathology in genomic research association, are related to metabolic aspects and body mass index in PCOS patients. Genomes have roles in chronic inflammation, followed by obesity, in the pathogenesis of PCOS. |
| first_indexed | 2024-12-21T06:53:30Z |
| format | Article |
| id | doaj.art-308199e540bc439b87aaeb61b046d3fb |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-21T06:53:30Z |
| publishDate | 2019-12-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-308199e540bc439b87aaeb61b046d3fb2022-12-21T19:12:24ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742019-12-0122121378138610.22038/ijbms.2019.1402914029Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndromeZahra Shaaban0Arezoo Khoradmehr1Amir Amiri-Yekta2Mohammad Reza Jafarzadeh Shirazi3Amin Tamadon4Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, IranResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, IranReproductive Biomedicine Research Center, Royan Institute, Tehran, IranDepartment of Animal Science, College of Agriculture, Shiraz University, Shiraz, IranThe Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran<em><strong>Objective(s):</strong></em> One of the common heterogeneous reproductive disorders in women of childbearing age is polycystic ovary syndrome (PCOS). It is characterized by lack of fertility due to anovulatory cycles, hyperandrogenemia, polycystic ovaries, hyperinsulinemia, and obesity. Both reproductive anomalies and metabolic disorders are involved in PCOS pathology. Although the role of increased levels of androgens in initiation of PCOS is almost proven, mechanisms of PCOS pathophysiology are not clear. Here we discuss roles of altered metabolic conditions, obesity, and chronic inflammation in PCOS pathophysiology.<br /><em><strong>Materials and Methods:</strong></em> In this review, we attempted to identify genes related to obesity and chronic inflammation aspects of PCOS and their physiological functions to explain the pathways that are regulated by these genes and can be a prominent function in PCOS predisposition. For this purpose, published articles and reviews dealing with genetic evaluation of PCOS in women in peer-reviewed journals in PubMed and Google Scholar databases were included in this review.<br /><em><strong>Results:</strong></em> Obesity and chronic inflammation are not prominent diagnostic features of PCOS, but they play an important role in exacerbating metabolic and hyperandrogenic states. ADIPOQ, FTO TGFβ, and DENND1A as the main obesity- and chronic inflammation-related genes have roles in PCOS pathophysiology.<br /><em><strong>Conclusion:</strong></em> It seems that genes related to obesity pathology in genomic research association, are related to metabolic aspects and body mass index in PCOS patients. Genomes have roles in chronic inflammation, followed by obesity, in the pathogenesis of PCOS.http://ijbms.mums.ac.ir/article_14029_079f70ecab79a8e4c29561a8eca4bdfc.pdfchronic inflammationgeneobesitypathophysiologypolycystic ovary syndrome |
| spellingShingle | Zahra Shaaban Arezoo Khoradmehr Amir Amiri-Yekta Mohammad Reza Jafarzadeh Shirazi Amin Tamadon Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome Iranian Journal of Basic Medical Sciences chronic inflammation gene obesity pathophysiology polycystic ovary syndrome |
| title | Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome |
| title_full | Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome |
| title_fullStr | Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome |
| title_full_unstemmed | Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome |
| title_short | Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome |
| title_sort | pathophysiologic mechanisms of obesity and chronic inflammation related genes in etiology of polycystic ovary syndrome |
| topic | chronic inflammation gene obesity pathophysiology polycystic ovary syndrome |
| url | http://ijbms.mums.ac.ir/article_14029_079f70ecab79a8e4c29561a8eca4bdfc.pdf |
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