The potential role of ferroptosis in COVID-19-related cardiovascular injury
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a global health threat in 2019. An important feature of the disease is that multiorgan symptoms of SARS-CoV-2 infection persist after recovery. Evidence indicates that people who recovered from COVID-19, eve...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222301435X |
| _version_ | 1797630659739516928 |
|---|---|
| author | Lei Yang Yunyi Wu Weidong Jin Nan Mo Gaoqi Ye Zixin Su Lusheng Tang Ying Wang Yanchun Li Jing Du |
| author_facet | Lei Yang Yunyi Wu Weidong Jin Nan Mo Gaoqi Ye Zixin Su Lusheng Tang Ying Wang Yanchun Li Jing Du |
| author_sort | Lei Yang |
| collection | DOAJ |
| description | COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a global health threat in 2019. An important feature of the disease is that multiorgan symptoms of SARS-CoV-2 infection persist after recovery. Evidence indicates that people who recovered from COVID-19, even those under the age of 65 years without cardiovascular risk factors such as smoking, obesity, hypertension, and diabetes, had a significantly increased risk of cardiovascular disease for up to one year after diagnosis. Therefore, it is important to closely monitor individuals who have recovered from COVID-19 for potential cardiovascular damage that may manifest at a later stage. Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by the production of reactive oxygen species (ROS) and increased lipid peroxide levels. Several studies have demonstrated that ferroptosis plays an important role in cancer, ischemia/reperfusion injury (I/RI), and other cardiovascular diseases. Altered iron metabolism, upregulation of reactive oxygen species, and glutathione peroxidase 4 inactivation are striking features of COVID-19-related cardiovascular injury. SARS-CoV-2 can cause cardiovascular ferroptosis, leading to cardiovascular damage. Understanding the mechanism of ferroptosis in COVID-19-related cardiovascular injuries will contribute to the development of treatment regimens for preventing or reducing COVID-19-related cardiovascular complications. In this article, we go over the pathophysiological underpinnings of SARS-CoV-2-induced acute and chronic cardiovascular injury, the function of ferroptosis, and prospective treatment approaches. |
| first_indexed | 2024-03-11T11:11:19Z |
| format | Article |
| id | doaj.art-3082c3cf3b3a4afd8c0ed790b5e6834e |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T11:11:19Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-3082c3cf3b3a4afd8c0ed790b5e6834e2023-11-12T04:38:43ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-12-01168115637The potential role of ferroptosis in COVID-19-related cardiovascular injuryLei Yang0Yunyi Wu1Weidong Jin2Nan Mo3Gaoqi Ye4Zixin Su5Lusheng Tang6Ying Wang7Yanchun Li8Jing Du9Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China; Department of Central Laboratory, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, ChinaLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, ChinaDepartment of Central Laboratory, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, ChinaLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, ChinaLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, ChinaDepartment of Central Laboratory, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Corresponding authors.Department of Central Laboratory, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Corresponding authors.Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China; Corresponding authors.COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a global health threat in 2019. An important feature of the disease is that multiorgan symptoms of SARS-CoV-2 infection persist after recovery. Evidence indicates that people who recovered from COVID-19, even those under the age of 65 years without cardiovascular risk factors such as smoking, obesity, hypertension, and diabetes, had a significantly increased risk of cardiovascular disease for up to one year after diagnosis. Therefore, it is important to closely monitor individuals who have recovered from COVID-19 for potential cardiovascular damage that may manifest at a later stage. Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by the production of reactive oxygen species (ROS) and increased lipid peroxide levels. Several studies have demonstrated that ferroptosis plays an important role in cancer, ischemia/reperfusion injury (I/RI), and other cardiovascular diseases. Altered iron metabolism, upregulation of reactive oxygen species, and glutathione peroxidase 4 inactivation are striking features of COVID-19-related cardiovascular injury. SARS-CoV-2 can cause cardiovascular ferroptosis, leading to cardiovascular damage. Understanding the mechanism of ferroptosis in COVID-19-related cardiovascular injuries will contribute to the development of treatment regimens for preventing or reducing COVID-19-related cardiovascular complications. In this article, we go over the pathophysiological underpinnings of SARS-CoV-2-induced acute and chronic cardiovascular injury, the function of ferroptosis, and prospective treatment approaches.http://www.sciencedirect.com/science/article/pii/S075333222301435XCOVID-19FerroptosisCardiovascular injurySARS-CoV-2Long-COVIDIron |
| spellingShingle | Lei Yang Yunyi Wu Weidong Jin Nan Mo Gaoqi Ye Zixin Su Lusheng Tang Ying Wang Yanchun Li Jing Du The potential role of ferroptosis in COVID-19-related cardiovascular injury Biomedicine & Pharmacotherapy COVID-19 Ferroptosis Cardiovascular injury SARS-CoV-2 Long-COVID Iron |
| title | The potential role of ferroptosis in COVID-19-related cardiovascular injury |
| title_full | The potential role of ferroptosis in COVID-19-related cardiovascular injury |
| title_fullStr | The potential role of ferroptosis in COVID-19-related cardiovascular injury |
| title_full_unstemmed | The potential role of ferroptosis in COVID-19-related cardiovascular injury |
| title_short | The potential role of ferroptosis in COVID-19-related cardiovascular injury |
| title_sort | potential role of ferroptosis in covid 19 related cardiovascular injury |
| topic | COVID-19 Ferroptosis Cardiovascular injury SARS-CoV-2 Long-COVID Iron |
| url | http://www.sciencedirect.com/science/article/pii/S075333222301435X |
| work_keys_str_mv | AT leiyang thepotentialroleofferroptosisincovid19relatedcardiovascularinjury AT yunyiwu thepotentialroleofferroptosisincovid19relatedcardiovascularinjury AT weidongjin thepotentialroleofferroptosisincovid19relatedcardiovascularinjury AT nanmo thepotentialroleofferroptosisincovid19relatedcardiovascularinjury AT gaoqiye thepotentialroleofferroptosisincovid19relatedcardiovascularinjury AT zixinsu thepotentialroleofferroptosisincovid19relatedcardiovascularinjury AT lushengtang thepotentialroleofferroptosisincovid19relatedcardiovascularinjury AT yingwang thepotentialroleofferroptosisincovid19relatedcardiovascularinjury AT yanchunli thepotentialroleofferroptosisincovid19relatedcardiovascularinjury AT jingdu thepotentialroleofferroptosisincovid19relatedcardiovascularinjury AT leiyang potentialroleofferroptosisincovid19relatedcardiovascularinjury AT yunyiwu potentialroleofferroptosisincovid19relatedcardiovascularinjury AT weidongjin potentialroleofferroptosisincovid19relatedcardiovascularinjury AT nanmo potentialroleofferroptosisincovid19relatedcardiovascularinjury AT gaoqiye potentialroleofferroptosisincovid19relatedcardiovascularinjury AT zixinsu potentialroleofferroptosisincovid19relatedcardiovascularinjury AT lushengtang potentialroleofferroptosisincovid19relatedcardiovascularinjury AT yingwang potentialroleofferroptosisincovid19relatedcardiovascularinjury AT yanchunli potentialroleofferroptosisincovid19relatedcardiovascularinjury AT jingdu potentialroleofferroptosisincovid19relatedcardiovascularinjury |