Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer’s Disease
Polyunsaturated fatty acids (PUFAs) are a class of fatty acids that are closely associated with the development and function of the brain. The most abundant PUFA is docosahexaenoic acid (DHA, 22:6 <i>n</i>-3). In humans, low plasmatic concentrations of DHA have been associated with impai...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/5/838 |
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| author | Charleine Zussy Rijo John Théo Urgin Léa Otaegui Claire Vigor Niyazi Acar Geoffrey Canet Mathieu Vitalis Françoise Morin Emmanuel Planel Camille Oger Thierry Durand Shinde L. Rajshree Laurent Givalois Padma V. Devarajan Catherine Desrumaux |
| author_facet | Charleine Zussy Rijo John Théo Urgin Léa Otaegui Claire Vigor Niyazi Acar Geoffrey Canet Mathieu Vitalis Françoise Morin Emmanuel Planel Camille Oger Thierry Durand Shinde L. Rajshree Laurent Givalois Padma V. Devarajan Catherine Desrumaux |
| author_sort | Charleine Zussy |
| collection | DOAJ |
| description | Polyunsaturated fatty acids (PUFAs) are a class of fatty acids that are closely associated with the development and function of the brain. The most abundant PUFA is docosahexaenoic acid (DHA, 22:6 <i>n</i>-3). In humans, low plasmatic concentrations of DHA have been associated with impaired cognitive function, low hippocampal volumes, and increased amyloid deposition in the brain. Several studies have reported reduced brain DHA concentrations in Alzheimer’s disease (AD) patients’ brains. Although a number of epidemiological studies suggest that dietary DHA consumption may protect the elderly from developing cognitive impairment or dementia including AD, several review articles report an inconclusive association between omega-3 PUFAs intake and cognitive decline. The source of these inconsistencies might be because DHA is highly oxidizable and its accessibility to the brain is limited by the blood–brain barrier. Thus, there is a pressing need for new strategies to improve DHA brain supply. In the present study, we show for the first time that the intranasal administration of nanovectorized DHA reduces Tau phosphorylation and restores cognitive functions in two complementary murine models of AD. These results pave the way for the development of a new approach to target the brain with DHA for the prevention or treatment of this devastating disease. |
| first_indexed | 2024-03-10T03:26:07Z |
| format | Article |
| id | doaj.art-308438b8e5884c3fac96cf4b86c265a0 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T03:26:07Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-308438b8e5884c3fac96cf4b86c265a02023-11-23T09:50:33ZengMDPI AGAntioxidants2076-39212022-04-0111583810.3390/antiox11050838Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer’s DiseaseCharleine Zussy0Rijo John1Théo Urgin2Léa Otaegui3Claire Vigor4Niyazi Acar5Geoffrey Canet6Mathieu Vitalis7Françoise Morin8Emmanuel Planel9Camille Oger10Thierry Durand11Shinde L. Rajshree12Laurent Givalois13Padma V. Devarajan14Catherine Desrumaux15MMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, FranceDepartment of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Deemed University, Mumbai 400019, IndiaMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, FranceMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, FranceIBMM, Pôle Chimie Balard Recherche, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, FranceCentre des Sciences du Goût et de l’Alimentation, AgroSup Dijon, CNRS, INRAE, Université de Bourgogne Franche-Comté, 21000 Dijon, FranceMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, FranceMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, FranceDepartment of Psychiatry and Neurosciences, Faculty of Medicine, Laval University, CR-CHUQ, Québec City, QC G1V 0A6, CanadaDepartment of Psychiatry and Neurosciences, Faculty of Medicine, Laval University, CR-CHUQ, Québec City, QC G1V 0A6, CanadaIBMM, Pôle Chimie Balard Recherche, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, FranceIBMM, Pôle Chimie Balard Recherche, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, FranceDepartment of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Deemed University, Mumbai 400019, IndiaMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, FranceDepartment of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Deemed University, Mumbai 400019, IndiaMMDN, University Montpellier, EPHE, INSERM, 34095 Montpellier, FrancePolyunsaturated fatty acids (PUFAs) are a class of fatty acids that are closely associated with the development and function of the brain. The most abundant PUFA is docosahexaenoic acid (DHA, 22:6 <i>n</i>-3). In humans, low plasmatic concentrations of DHA have been associated with impaired cognitive function, low hippocampal volumes, and increased amyloid deposition in the brain. Several studies have reported reduced brain DHA concentrations in Alzheimer’s disease (AD) patients’ brains. Although a number of epidemiological studies suggest that dietary DHA consumption may protect the elderly from developing cognitive impairment or dementia including AD, several review articles report an inconclusive association between omega-3 PUFAs intake and cognitive decline. The source of these inconsistencies might be because DHA is highly oxidizable and its accessibility to the brain is limited by the blood–brain barrier. Thus, there is a pressing need for new strategies to improve DHA brain supply. In the present study, we show for the first time that the intranasal administration of nanovectorized DHA reduces Tau phosphorylation and restores cognitive functions in two complementary murine models of AD. These results pave the way for the development of a new approach to target the brain with DHA for the prevention or treatment of this devastating disease.https://www.mdpi.com/2076-3921/11/5/838omega-3 fatty acidsdocosahexaenoic acidcurcuminAlzheimer’s diseaseamyloid-β peptideintranasal |
| spellingShingle | Charleine Zussy Rijo John Théo Urgin Léa Otaegui Claire Vigor Niyazi Acar Geoffrey Canet Mathieu Vitalis Françoise Morin Emmanuel Planel Camille Oger Thierry Durand Shinde L. Rajshree Laurent Givalois Padma V. Devarajan Catherine Desrumaux Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer’s Disease Antioxidants omega-3 fatty acids docosahexaenoic acid curcumin Alzheimer’s disease amyloid-β peptide intranasal |
| title | Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer’s Disease |
| title_full | Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer’s Disease |
| title_fullStr | Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer’s Disease |
| title_full_unstemmed | Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer’s Disease |
| title_short | Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer’s Disease |
| title_sort | intranasal administration of nanovectorized docosahexaenoic acid dha improves cognitive function in two complementary mouse models of alzheimer s disease |
| topic | omega-3 fatty acids docosahexaenoic acid curcumin Alzheimer’s disease amyloid-β peptide intranasal |
| url | https://www.mdpi.com/2076-3921/11/5/838 |
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