Ghrelin Levels in Children With Intestinal Failure Receiving Long-Term Parenteral Nutrition
BackgroundChildren with intestinal failure (IF) require parenteral nutrition (PN). Transition to oral and enteral nutrition (EN) can be difficult also due to abnormal gastrointestinal motility. The gut hormone ghrelin is increased in states of negative energy balance, functioning to preserve euglyce...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.896328/full |
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| author | Lotte E. Vlug Patric J. D. Delhanty Esther G. Neelis Martin Huisman Jenny A. Visser Edmond H. H. M. Rings Edmond H. H. M. Rings René M. H. Wijnen Sjoerd C. J. Nagelkerke Merit M. Tabbers Jessie M. Hulst Barbara A. E. de Koning |
| author_facet | Lotte E. Vlug Patric J. D. Delhanty Esther G. Neelis Martin Huisman Jenny A. Visser Edmond H. H. M. Rings Edmond H. H. M. Rings René M. H. Wijnen Sjoerd C. J. Nagelkerke Merit M. Tabbers Jessie M. Hulst Barbara A. E. de Koning |
| author_sort | Lotte E. Vlug |
| collection | DOAJ |
| description | BackgroundChildren with intestinal failure (IF) require parenteral nutrition (PN). Transition to oral and enteral nutrition (EN) can be difficult also due to abnormal gastrointestinal motility. The gut hormone ghrelin is increased in states of negative energy balance, functioning to preserve euglycemia, and also has appetite stimulating and prokinetic properties. We aimed to evaluate and compare ghrelin levels in children with IF, and to assess the relationship with PN-dependency.MethodsIn this exploratory prospective multicenter study, plasma acylated (AG) and unacylated (UAG) ghrelin levels were measured in children with short bowel syndrome (SBS) and with functional IF (pseudo-obstruction or any enteropathy) and compared with healthy control subjects. Spearman’s rho (rs) was used to assess correlations of AG and UAG with PN-dependency (%PN) and parenteral glucose intake.ResultsSixty-four samples from 36 IF-patients were analyzed. Median baseline AG and UAG levels were respectively 279.2 and 101.0 pg/mL in children with SBS (n = 16), 126.4 and 84.5 pg/mL in children with functional IF (n = 20) and 82.4 and 157.3 pg/mL in healthy children (n = 39). AG levels were higher in children with SBS and functional IF than in healthy children (p = 0.002 and p = 0.023, respectively). In SBS, AG positively correlated with %PN (rs = 0.5, p = 0.005) and parenteral glucose intake (rs = 0.6, p = 0.003). These correlations were not observed in functional IF.ConclusionChildren with IF had raised AG levels which could be related to starvation of the gut. The positive correlation between AG and glucose infusion rate in SBS suggests an altered glucoregulatory function. |
| first_indexed | 2024-12-12T04:41:25Z |
| format | Article |
| id | doaj.art-3084db30791b44a481ef4d22572d4282 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-12T04:41:25Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-3084db30791b44a481ef4d22572d42822022-12-22T00:37:48ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-05-01910.3389/fnut.2022.896328896328Ghrelin Levels in Children With Intestinal Failure Receiving Long-Term Parenteral NutritionLotte E. Vlug0Patric J. D. Delhanty1Esther G. Neelis2Martin Huisman3Jenny A. Visser4Edmond H. H. M. Rings5Edmond H. H. M. Rings6René M. H. Wijnen7Sjoerd C. J. Nagelkerke8Merit M. Tabbers9Jessie M. Hulst10Barbara A. E. de Koning11Division of Gastroenterology, Department of Pediatrics, Erasmus MC Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, NetherlandsDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, NetherlandsDivision of Gastroenterology, Department of Pediatrics, Erasmus MC Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, NetherlandsDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, NetherlandsDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, NetherlandsDivision of Gastroenterology, Department of Pediatrics, Erasmus MC Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, NetherlandsDivision of Gastroenterology, Department of Pediatrics, Willem Alexander Children’s Hospital, Leiden University Medical Center, Leiden, NetherlandsDepartment of Pediatric Surgery, Erasmus MC Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, NetherlandsDivision of Gastroenterology, Department of Pediatrics, Emma Children’s Hospital, Amsterdam University Medical Centers, Amsterdam, NetherlandsDivision of Gastroenterology, Department of Pediatrics, Emma Children’s Hospital, Amsterdam University Medical Centers, Amsterdam, NetherlandsDivision of Paediatric Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, ON, CanadaDivision of Gastroenterology, Department of Pediatrics, Erasmus MC Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, NetherlandsBackgroundChildren with intestinal failure (IF) require parenteral nutrition (PN). Transition to oral and enteral nutrition (EN) can be difficult also due to abnormal gastrointestinal motility. The gut hormone ghrelin is increased in states of negative energy balance, functioning to preserve euglycemia, and also has appetite stimulating and prokinetic properties. We aimed to evaluate and compare ghrelin levels in children with IF, and to assess the relationship with PN-dependency.MethodsIn this exploratory prospective multicenter study, plasma acylated (AG) and unacylated (UAG) ghrelin levels were measured in children with short bowel syndrome (SBS) and with functional IF (pseudo-obstruction or any enteropathy) and compared with healthy control subjects. Spearman’s rho (rs) was used to assess correlations of AG and UAG with PN-dependency (%PN) and parenteral glucose intake.ResultsSixty-four samples from 36 IF-patients were analyzed. Median baseline AG and UAG levels were respectively 279.2 and 101.0 pg/mL in children with SBS (n = 16), 126.4 and 84.5 pg/mL in children with functional IF (n = 20) and 82.4 and 157.3 pg/mL in healthy children (n = 39). AG levels were higher in children with SBS and functional IF than in healthy children (p = 0.002 and p = 0.023, respectively). In SBS, AG positively correlated with %PN (rs = 0.5, p = 0.005) and parenteral glucose intake (rs = 0.6, p = 0.003). These correlations were not observed in functional IF.ConclusionChildren with IF had raised AG levels which could be related to starvation of the gut. The positive correlation between AG and glucose infusion rate in SBS suggests an altered glucoregulatory function.https://www.frontiersin.org/articles/10.3389/fnut.2022.896328/fullacylated ghrelinunacylated ghrelinshort bowel syndromeenteral autonomyintestinal adaptationpediatrics |
| spellingShingle | Lotte E. Vlug Patric J. D. Delhanty Esther G. Neelis Martin Huisman Jenny A. Visser Edmond H. H. M. Rings Edmond H. H. M. Rings René M. H. Wijnen Sjoerd C. J. Nagelkerke Merit M. Tabbers Jessie M. Hulst Barbara A. E. de Koning Ghrelin Levels in Children With Intestinal Failure Receiving Long-Term Parenteral Nutrition Frontiers in Nutrition acylated ghrelin unacylated ghrelin short bowel syndrome enteral autonomy intestinal adaptation pediatrics |
| title | Ghrelin Levels in Children With Intestinal Failure Receiving Long-Term Parenteral Nutrition |
| title_full | Ghrelin Levels in Children With Intestinal Failure Receiving Long-Term Parenteral Nutrition |
| title_fullStr | Ghrelin Levels in Children With Intestinal Failure Receiving Long-Term Parenteral Nutrition |
| title_full_unstemmed | Ghrelin Levels in Children With Intestinal Failure Receiving Long-Term Parenteral Nutrition |
| title_short | Ghrelin Levels in Children With Intestinal Failure Receiving Long-Term Parenteral Nutrition |
| title_sort | ghrelin levels in children with intestinal failure receiving long term parenteral nutrition |
| topic | acylated ghrelin unacylated ghrelin short bowel syndrome enteral autonomy intestinal adaptation pediatrics |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.896328/full |
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