Say NO to ROS: Their Roles in Embryonic Heart Development and Pathogenesis of Congenital Heart Defects in Maternal Diabetes

Say NO to ROS: Their Roles in Embryonic Heart Development and Pathogenesis of Congenital Heart Defects in Maternal Diabetes

Congenital heart defects (CHDs) are the most prevalent and serious birth defect, occurring in 1% of all live births. Pregestational maternal diabetes is a known risk factor for the development of CHDs, elevating the risk in the child by more than four-fold. As the prevalence of diabetes rapidly rise...

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Bibliographic Details
Main Authors: Anish Engineer, Tana Saiyin, Elizabeth R. Greco, Qingping Feng
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Antioxidants
Subjects:
congenital heart defects
pregestational diabetes
nitric oxide
reactive oxygen species
enos
heart development
tetrahydrobiopterin
oxidative stress
antioxidant
exercise
Online Access:https://www.mdpi.com/2076-3921/8/10/436

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