SHP-2-Induced Activation of c-Myc Is Involved in PDGF-B-Regulated Cell Proliferation and Angiogenesis in RMECs

SHP-2-Induced Activation of c-Myc Is Involved in PDGF-B-Regulated Cell Proliferation and Angiogenesis in RMECs

Background: Aberrant neovascularization resulting from inappropriate angiogenic signaling is closely related to many diseases, such as cancer, cardiovascular disease, and proliferative retinopathy. Although some factors involved in regulating pathogenic angiogenesis have been identified, the molecul...

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Bibliographic Details
Main Authors: Jun Ma, Wenyi Tang, Ruiping Gu, Fangyuan Hu, Lei Zhang, Jihong Wu, Gezhi Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Physiology
Subjects:
retina
proliferation
angiogenesis
PDGF-B
SHP-2
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.555006/full

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