Identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root angles
Summary: The lateral root angle or gravitropic set-point angle (GSA) is an important trait for root system architecture (RSA) that determines the radial expansion of the root system. The GSA therefore plays a crucial role for the ability of plants to access nutrients and water in the soil. Only a fe...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724000913 |
| _version_ | 1797291755926716416 |
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| author | Wenrong He Hai An Truong Ling Zhang Min Cao Neal Arakawa Yao Xiao Kaizhen Zhong Yingnan Hou Wolfgang Busch |
| author_facet | Wenrong He Hai An Truong Ling Zhang Min Cao Neal Arakawa Yao Xiao Kaizhen Zhong Yingnan Hou Wolfgang Busch |
| author_sort | Wenrong He |
| collection | DOAJ |
| description | Summary: The lateral root angle or gravitropic set-point angle (GSA) is an important trait for root system architecture (RSA) that determines the radial expansion of the root system. The GSA therefore plays a crucial role for the ability of plants to access nutrients and water in the soil. Only a few regulatory pathways and mechanisms that determine GSA are known. These mostly relate to auxin and cytokinin pathways. Here, we report the identification of a small molecule, mebendazole (MBZ), that modulates GSA in Arabidopsis thaliana roots and acts via the activation of ethylene signaling. MBZ directly acts on the serine/threonine protein kinase CTR1, which is a negative regulator of ethylene signaling. Our study not only shows that the ethylene signaling pathway is essential for GSA regulation but also identifies a small molecular modulator of RSA that acts downstream of ethylene receptors and that directly activates ethylene signaling. |
| first_indexed | 2024-03-07T19:42:18Z |
| format | Article |
| id | doaj.art-3089d54160664686b8b61cf8fdf5bc38 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-07T19:42:18Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-3089d54160664686b8b61cf8fdf5bc382024-02-29T05:18:54ZengElsevierCell Reports2211-12472024-02-01432113763Identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root anglesWenrong He0Hai An Truong1Ling Zhang2Min Cao3Neal Arakawa4Yao Xiao5Kaizhen Zhong6Yingnan Hou7Wolfgang Busch8Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USAPlant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USAPlant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USAPlant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USAEnvironmental and Complex Analysis Laboratory (ECAL), Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USADepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USAPlant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USADepartment of Microbiology and Plant Pathology, Center for Plant Cell Biology, University of California, Riverside, Riverside, CA 92521, USA; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, ChinaPlant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Integrative Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Corresponding authorSummary: The lateral root angle or gravitropic set-point angle (GSA) is an important trait for root system architecture (RSA) that determines the radial expansion of the root system. The GSA therefore plays a crucial role for the ability of plants to access nutrients and water in the soil. Only a few regulatory pathways and mechanisms that determine GSA are known. These mostly relate to auxin and cytokinin pathways. Here, we report the identification of a small molecule, mebendazole (MBZ), that modulates GSA in Arabidopsis thaliana roots and acts via the activation of ethylene signaling. MBZ directly acts on the serine/threonine protein kinase CTR1, which is a negative regulator of ethylene signaling. Our study not only shows that the ethylene signaling pathway is essential for GSA regulation but also identifies a small molecular modulator of RSA that acts downstream of ethylene receptors and that directly activates ethylene signaling.http://www.sciencedirect.com/science/article/pii/S2211124724000913CP: Plants |
| spellingShingle | Wenrong He Hai An Truong Ling Zhang Min Cao Neal Arakawa Yao Xiao Kaizhen Zhong Yingnan Hou Wolfgang Busch Identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root angles Cell Reports CP: Plants |
| title | Identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root angles |
| title_full | Identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root angles |
| title_fullStr | Identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root angles |
| title_full_unstemmed | Identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root angles |
| title_short | Identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root angles |
| title_sort | identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root angles |
| topic | CP: Plants |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724000913 |
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