Mathematical Modeling of Biosensors Based on an Array of Enzyme Microreactors

This paper presents a two-dimensional-in-space mathematical model ofbiosensors based on an array of enzyme microreactors immobilised on a single electrode.The modeling system acts under amperometric conditions. The microreactors were modeledby particles and by strips. The model is based on the diffu...

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Bibliographic Details
Main Authors: Juozas Kulys, Feliksas Ivanauskas, Romas Baronas
Format: Article
Language:English
Published: MDPI AG 2006-04-01
Series:Sensors
Subjects:
Online Access:http://www.mdpi.com/1424-8220/6/4/453/
Description
Summary:This paper presents a two-dimensional-in-space mathematical model ofbiosensors based on an array of enzyme microreactors immobilised on a single electrode.The modeling system acts under amperometric conditions. The microreactors were modeledby particles and by strips. The model is based on the diffusion equations containing a non-linear term related to the Michaelis-Menten kinetics of the enzymatic reaction. The modelinvolves three regions: an array of enzyme microreactors where enzyme reaction as well asmass transport by diffusion takes place, a diffusion limiting region where only the diffusiontakes place, and a convective region, where the analyte concentration is maintained constant.Using computer simulation, the influence of the geometry of the microreactors and of thediffusion region on the biosensor response was investigated. The digital simulation wascarried out using the finite difference technique.
ISSN:1424-8220