Predictors Associated with Adverse Pregnancy Outcomes in a Cohort of Women with Systematic Lupus Erythematosus from Romania—An Observational Study (Stage 2)
Background: Pregnancy in women with systemic lupus erythematosus (SLE) is accompanied by adverse pregnancy outcomes (APOs). We aimed to investigate the association between clinical, sonographic, and laboratory parameters and APOs (preeclampsia, intrauterine growth restriction, premature birth, and m...
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MDPI AG
2022-04-01
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| author | Petronela Vicoveanu Ingrid-Andrada Vasilache Dragos Nemescu Alexandru Carauleanu Ioana-Sadiye Scripcariu Dorina Rudisteanu Alexandra Burlui Elena Rezus Demetra Socolov |
| author_facet | Petronela Vicoveanu Ingrid-Andrada Vasilache Dragos Nemescu Alexandru Carauleanu Ioana-Sadiye Scripcariu Dorina Rudisteanu Alexandra Burlui Elena Rezus Demetra Socolov |
| author_sort | Petronela Vicoveanu |
| collection | DOAJ |
| description | Background: Pregnancy in women with systemic lupus erythematosus (SLE) is accompanied by adverse pregnancy outcomes (APOs). We aimed to investigate the association between clinical, sonographic, and laboratory parameters and APOs (preeclampsia, intrauterine growth restriction, premature birth, and maternal mortality). Methods: This observational retrospective study included all pregnancies in women with SLE who attended two tertiary maternity hospitals from Romania between January 2013 and December 2020. Clinical, sonographic, and laboratory variables were examined. Bivariate associations of APO status and each predictor variable were evaluated, and significant predictors were further included in a classification model based on discriminant analysis. Results: Predictors of APOs included BMI > 25 kg/m<sup>2</sup>, personal history of lupus nephritis or chronic hypertension, proteinuria, low C3, SLE Disease Activity Index 2000 (SLEDAI-2k score ≥ 4 and physician’s global-assessment (PGA) score ≥ 1 throughout pregnancy, increased mean uterine arteries pulsatility index in the first and second trimesters, cerebroplacental ratio < 1 in the second and third trimesters, and small fetal abdominal circumference in the third trimester. Glucocorticoids, methyldopa, and aspirin use appeared to be protective against APOs. Conclusions: This study provides a comprehensive analysis of the most important predictors for APOs in pregnant patients with SLE, which could constitute a basis for further research. |
| first_indexed | 2024-03-09T11:42:17Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T11:42:17Z |
| publishDate | 2022-04-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-308a203b8fe947b6b4adf52fa1c89d132023-11-30T23:29:17ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01117196410.3390/jcm11071964Predictors Associated with Adverse Pregnancy Outcomes in a Cohort of Women with Systematic Lupus Erythematosus from Romania—An Observational Study (Stage 2)Petronela Vicoveanu0Ingrid-Andrada Vasilache1Dragos Nemescu2Alexandru Carauleanu3Ioana-Sadiye Scripcariu4Dorina Rudisteanu5Alexandra Burlui6Elena Rezus7Demetra Socolov8Department of Obstetrics and Gynecology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Obstetrics and Gynecology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Obstetrics and Gynecology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Obstetrics and Gynecology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Obstetrics and Gynecology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Obstetrics and Gynecology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Rheumatology and Rehabilitation, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Rheumatology and Rehabilitation, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Obstetrics and Gynecology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, RomaniaBackground: Pregnancy in women with systemic lupus erythematosus (SLE) is accompanied by adverse pregnancy outcomes (APOs). We aimed to investigate the association between clinical, sonographic, and laboratory parameters and APOs (preeclampsia, intrauterine growth restriction, premature birth, and maternal mortality). Methods: This observational retrospective study included all pregnancies in women with SLE who attended two tertiary maternity hospitals from Romania between January 2013 and December 2020. Clinical, sonographic, and laboratory variables were examined. Bivariate associations of APO status and each predictor variable were evaluated, and significant predictors were further included in a classification model based on discriminant analysis. Results: Predictors of APOs included BMI > 25 kg/m<sup>2</sup>, personal history of lupus nephritis or chronic hypertension, proteinuria, low C3, SLE Disease Activity Index 2000 (SLEDAI-2k score ≥ 4 and physician’s global-assessment (PGA) score ≥ 1 throughout pregnancy, increased mean uterine arteries pulsatility index in the first and second trimesters, cerebroplacental ratio < 1 in the second and third trimesters, and small fetal abdominal circumference in the third trimester. Glucocorticoids, methyldopa, and aspirin use appeared to be protective against APOs. Conclusions: This study provides a comprehensive analysis of the most important predictors for APOs in pregnant patients with SLE, which could constitute a basis for further research.https://www.mdpi.com/2077-0383/11/7/1964predictorsadverse pregnancy outcomessystemic lupus erythematosus |
| spellingShingle | Petronela Vicoveanu Ingrid-Andrada Vasilache Dragos Nemescu Alexandru Carauleanu Ioana-Sadiye Scripcariu Dorina Rudisteanu Alexandra Burlui Elena Rezus Demetra Socolov Predictors Associated with Adverse Pregnancy Outcomes in a Cohort of Women with Systematic Lupus Erythematosus from Romania—An Observational Study (Stage 2) Journal of Clinical Medicine predictors adverse pregnancy outcomes systemic lupus erythematosus |
| title | Predictors Associated with Adverse Pregnancy Outcomes in a Cohort of Women with Systematic Lupus Erythematosus from Romania—An Observational Study (Stage 2) |
| title_full | Predictors Associated with Adverse Pregnancy Outcomes in a Cohort of Women with Systematic Lupus Erythematosus from Romania—An Observational Study (Stage 2) |
| title_fullStr | Predictors Associated with Adverse Pregnancy Outcomes in a Cohort of Women with Systematic Lupus Erythematosus from Romania—An Observational Study (Stage 2) |
| title_full_unstemmed | Predictors Associated with Adverse Pregnancy Outcomes in a Cohort of Women with Systematic Lupus Erythematosus from Romania—An Observational Study (Stage 2) |
| title_short | Predictors Associated with Adverse Pregnancy Outcomes in a Cohort of Women with Systematic Lupus Erythematosus from Romania—An Observational Study (Stage 2) |
| title_sort | predictors associated with adverse pregnancy outcomes in a cohort of women with systematic lupus erythematosus from romania an observational study stage 2 |
| topic | predictors adverse pregnancy outcomes systemic lupus erythematosus |
| url | https://www.mdpi.com/2077-0383/11/7/1964 |
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