Minimally invasive surgery versus laparotomy in women with high risk endometrial cancer: A multi-center study performed in Argentina
Objective: Compare the perioperative outcomes and disease-free survival between minimally invasive and open surgery in women with stage I–II high-risk endometrial cancer. Methods: A retrospective, cohort study was performed involving twenty-four centers from Argentina. Patients with grade 3 endometr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-04-01
|
| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578923000164 |
| _version_ | 1827971436924370944 |
|---|---|
| author | Diego Odetto Guido Martin Rey Valzacchi Marcela Ostojich Sebastian Alessandria Maria Cecilia Darin Karen Tapper Alicia Rita Amato Federico Luis Bianchi Eduardo Fabian Lopresti Lorena Soledad Cabrera Jerónimo Costa Agustín Esteban Luciana Prozzillo Horacio Escobar Daniel Gacitua Bustos Otilio Daniel Rosato Ricardo Anibal Picciochi Rosa María Garrido Graciela Lopez de Degani María Soledad Del Valle Vitale Roberto Hugo Navarini Facundo Isnardi Gonzalo Franco Mariano Rossini María Mercedes Carrizo Myriam Perrotta Gabriel Crimi |
| author_facet | Diego Odetto Guido Martin Rey Valzacchi Marcela Ostojich Sebastian Alessandria Maria Cecilia Darin Karen Tapper Alicia Rita Amato Federico Luis Bianchi Eduardo Fabian Lopresti Lorena Soledad Cabrera Jerónimo Costa Agustín Esteban Luciana Prozzillo Horacio Escobar Daniel Gacitua Bustos Otilio Daniel Rosato Ricardo Anibal Picciochi Rosa María Garrido Graciela Lopez de Degani María Soledad Del Valle Vitale Roberto Hugo Navarini Facundo Isnardi Gonzalo Franco Mariano Rossini María Mercedes Carrizo Myriam Perrotta Gabriel Crimi |
| author_sort | Diego Odetto |
| collection | DOAJ |
| description | Objective: Compare the perioperative outcomes and disease-free survival between minimally invasive and open surgery in women with stage I–II high-risk endometrial cancer. Methods: A retrospective, cohort study was performed involving twenty-four centers from Argentina. Patients with grade 3 endometrioid, serous, clear cell, undifferentiated carcinoma or carcinosarcoma who underwent hysterectomy, bilateral salpingo-oophorectomy, and staging between January 2010–2018 were included. Cox hazard regression analysis and Kaplan-Meier curves evaluated the association of surgical technique with survival. Results: Of 343 eligible patients, 214 (62 %) underwent open surgery and 129 (38 %) underwent laparoscopic surgery. No significant differences were seen between the two groups with respect to greater or equal grade III Clavien-Dindo postoperative complications (11 % in the open surgery group vs 9 % minimally invasive surgery group; P = 0.34) Minimally invasive surgery was not associated with worse disease-free survival at four years (79.14 % [95 % CI 69.42– 86.08] vs 78.80 % [95 % CI 70.61–84.96]), (p = 0.25), even after creating a Cox proportional model (hazard ratio [HR] 1.08 95 % CI 0.63–1.84); (p = 0.76). Conclusion: There was no difference between postoperative complications nor oncologic outcomes comparing minimally invasive and open surgery among patients with high-risk endometrial cancer. |
| first_indexed | 2024-04-09T19:08:58Z |
| format | Article |
| id | doaj.art-308a3f843ef048aca98b46368ad9f509 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-04-09T19:08:58Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-308a3f843ef048aca98b46368ad9f5092023-04-07T06:50:26ZengElsevierGynecologic Oncology Reports2352-57892023-04-0146101147Minimally invasive surgery versus laparotomy in women with high risk endometrial cancer: A multi-center study performed in ArgentinaDiego Odetto0Guido Martin Rey Valzacchi1Marcela Ostojich2Sebastian Alessandria3Maria Cecilia Darin4Karen Tapper5Alicia Rita Amato6Federico Luis Bianchi7Eduardo Fabian Lopresti8Lorena Soledad Cabrera9Jerónimo Costa10Agustín Esteban11Luciana Prozzillo12Horacio Escobar13Daniel Gacitua Bustos14Otilio Daniel Rosato15Ricardo Anibal Picciochi16Rosa María Garrido17Graciela Lopez de Degani18María Soledad Del Valle Vitale19Roberto Hugo Navarini20Facundo Isnardi21Gonzalo Franco22Mariano Rossini23María Mercedes Carrizo24Myriam Perrotta25Gabriel Crimi26Gynecology Oncology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Corresponding author.Department of Gynecologic Oncology, Hospital Italiano de Buenos Aires, Buenos Aires, ArgentinaDepartment of Gynecology, Institute of Oncology Angel H. Roffo, University of Buenos Aires, ArgentinaDepartment of Gynecologic Oncology, Sanatorio Sagrado Corazón, Buenos Aires, ArgentinaDepartment of Gynecology, Hospital Británico de Buenos Aires, Buenos Aires, ArgentinaCenter for Medical Education and Clinical Investigation (CEMIC), Buenos Aires, ArgentinaDepartment of Gynecology, Complejo Médico Policial “Churruca-Visca”, Buenos Aires, ArgentinaDepartment of Gynecology, Hospital Aleman de Buenos Aires, Buenos Aires, ArgentinaDepartment of Gynecology, Hospital Central, Mendoza, ArgentinaDepartment of Gynecology, Hospital Provincial Neuquén, Neuquén, ArgentinaDepartment of Gynecology, Hospital Privado de Rosario, Santa Fe, ArgentinaDepartment of Gynecology, Sanatorio Allende, Córdoba, ArgentinaDepartment of Gynecology, Hospital Español, Buenos Aires, ArgentinaDepartment of Gynecology, Hospital Italiano Córdoba, Córdoba, ArgentinaDepartment of Gynecology, Hospital Privado de Córdoba, Córdoba, ArgentinaDepartment of Gynecology, Hospital Universitario de Maternidad y Neonatología de la Ciudad de Córdoba, Córdoba, ArgentinaDepartment of Gynecology, Hospital José María Cullen, Santa Fe, ArgentinaDepartment of Gynecologic Oncology, Marie Curie, Buenos Aires, ArgentinaDepartment of Gynecology, Hospital San Martín, Paraná, Entre Ríos, ArgentinaDepartment of Gynecology.Hospital General de Agudos José María Penna, Buenos Aires, ArgentinaDepartment of Gynecology, Hospital Clemente Alvarez, Santa Fe, ArgentinaDepartment of Gynecology, Hospital Italiano Rosario, Santa Fe, ArgentinaDepartment of Gynecology, Hospital Nacional de Clínicas, Córdoba, ArgentinaDepartment of Gynecology, Clínica del Niño y la Familia, Mar del Plata, ArgentinaDepartment of Gynecology, Hospital Zonal Carlos Bocalandro, Buenos Aires, ArgentinaDepartment of Gynecologic Oncology, Hospital Italiano de Buenos Aires, Buenos Aires, ArgentinaCenter for Medical Education and Clinical Investigation (CEMIC), Buenos Aires, ArgentinaObjective: Compare the perioperative outcomes and disease-free survival between minimally invasive and open surgery in women with stage I–II high-risk endometrial cancer. Methods: A retrospective, cohort study was performed involving twenty-four centers from Argentina. Patients with grade 3 endometrioid, serous, clear cell, undifferentiated carcinoma or carcinosarcoma who underwent hysterectomy, bilateral salpingo-oophorectomy, and staging between January 2010–2018 were included. Cox hazard regression analysis and Kaplan-Meier curves evaluated the association of surgical technique with survival. Results: Of 343 eligible patients, 214 (62 %) underwent open surgery and 129 (38 %) underwent laparoscopic surgery. No significant differences were seen between the two groups with respect to greater or equal grade III Clavien-Dindo postoperative complications (11 % in the open surgery group vs 9 % minimally invasive surgery group; P = 0.34) Minimally invasive surgery was not associated with worse disease-free survival at four years (79.14 % [95 % CI 69.42– 86.08] vs 78.80 % [95 % CI 70.61–84.96]), (p = 0.25), even after creating a Cox proportional model (hazard ratio [HR] 1.08 95 % CI 0.63–1.84); (p = 0.76). Conclusion: There was no difference between postoperative complications nor oncologic outcomes comparing minimally invasive and open surgery among patients with high-risk endometrial cancer.http://www.sciencedirect.com/science/article/pii/S2352578923000164Endometrial cancerGynecologic surgical proceduresPerioperative complicationsSurgical oncologySurgical procedures |
| spellingShingle | Diego Odetto Guido Martin Rey Valzacchi Marcela Ostojich Sebastian Alessandria Maria Cecilia Darin Karen Tapper Alicia Rita Amato Federico Luis Bianchi Eduardo Fabian Lopresti Lorena Soledad Cabrera Jerónimo Costa Agustín Esteban Luciana Prozzillo Horacio Escobar Daniel Gacitua Bustos Otilio Daniel Rosato Ricardo Anibal Picciochi Rosa María Garrido Graciela Lopez de Degani María Soledad Del Valle Vitale Roberto Hugo Navarini Facundo Isnardi Gonzalo Franco Mariano Rossini María Mercedes Carrizo Myriam Perrotta Gabriel Crimi Minimally invasive surgery versus laparotomy in women with high risk endometrial cancer: A multi-center study performed in Argentina Gynecologic Oncology Reports Endometrial cancer Gynecologic surgical procedures Perioperative complications Surgical oncology Surgical procedures |
| title | Minimally invasive surgery versus laparotomy in women with high risk endometrial cancer: A multi-center study performed in Argentina |
| title_full | Minimally invasive surgery versus laparotomy in women with high risk endometrial cancer: A multi-center study performed in Argentina |
| title_fullStr | Minimally invasive surgery versus laparotomy in women with high risk endometrial cancer: A multi-center study performed in Argentina |
| title_full_unstemmed | Minimally invasive surgery versus laparotomy in women with high risk endometrial cancer: A multi-center study performed in Argentina |
| title_short | Minimally invasive surgery versus laparotomy in women with high risk endometrial cancer: A multi-center study performed in Argentina |
| title_sort | minimally invasive surgery versus laparotomy in women with high risk endometrial cancer a multi center study performed in argentina |
| topic | Endometrial cancer Gynecologic surgical procedures Perioperative complications Surgical oncology Surgical procedures |
| url | http://www.sciencedirect.com/science/article/pii/S2352578923000164 |
| work_keys_str_mv | AT diegoodetto minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT guidomartinreyvalzacchi minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT marcelaostojich minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT sebastianalessandria minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT mariaceciliadarin minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT karentapper minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT aliciaritaamato minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT federicoluisbianchi minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT eduardofabianlopresti minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT lorenasoledadcabrera minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT jeronimocosta minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT agustinesteban minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT lucianaprozzillo minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT horacioescobar minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT danielgacituabustos minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT otiliodanielrosato minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT ricardoanibalpicciochi minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT rosamariagarrido minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT gracielalopezdedegani minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT mariasoledaddelvallevitale minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT robertohugonavarini minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT facundoisnardi minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT gonzalofranco minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT marianorossini minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT mariamercedescarrizo minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT myriamperrotta minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina AT gabrielcrimi minimallyinvasivesurgeryversuslaparotomyinwomenwithhighriskendometrialcanceramulticenterstudyperformedinargentina |